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Protein

GTP-binding nuclear protein GSP2/CNR2

Gene

GSP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Not essential for cell viability.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • nucleus organization Source: SGD
  • protein import into nucleus Source: GO_Central
  • ribosomal subunit export from nucleus Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33695-MONOMER.
ReactomeiR-SCE-203927. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein GSP2/CNR2
Gene namesi
Name:GSP2
Synonyms:CNR2
Ordered Locus Names:YOR185C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR185C.
SGDiS000005711. GSP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 220219GTP-binding nuclear protein GSP2/CNR2PRO_0000208734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP32836.
PRIDEiP32836.

PTM databases

iPTMnetiP32836.

Expressioni

Inductioni

GSP2 expression exhibits carbon source dependency.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MOG1P471233EBI-7934,EBI-11145

Protein-protein interaction databases

BioGridi34580. 41 interactions.
DIPiDIP-1357N.
IntActiP32836. 12 interactions.
MINTiMINT-384600.

Chemistry

BindingDBiP32836.

Structurei

3D structure databases

ProteinModelPortaliP32836.
SMRiP32836. Positions 11-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
InParanoidiP32836.
KOiK07936.
OMAiFRVCENI.
OrthoDBiEOG092C4F6L.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPAQNNAE VPTFKLVLVG DGGTGKTTFV KRHLTGEFEK KYIATIGVEV
60 70 80 90 100
HPLSFYTNFG EIKFDVWDTA GQEKFGGLRD GYYINAQCAI IMFDVTSRIT
110 120 130 140 150
YKNVPNWHRD LVRVCENIPI VLCGNKVDVK ERKVKAKTIT FHRKKNLQYY
160 170 180 190 200
DISAKSNYNF EKPFLWLARK LAGNPQLEFV ASPALAPPEV QVDEQLMHQY
210 220
QQEMDQATAL PLPDEDDADL
Length:220
Mass (Da):24,991
Last modified:October 1, 1993 - v1
Checksum:i402EEE0F140B37A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08691 Genomic DNA. Translation: AAA34654.1.
X71946 Genomic DNA. Translation: CAA50748.1.
Z75093 Genomic DNA. Translation: CAA99394.1.
AY693117 Genomic DNA. Translation: AAT93136.1.
BK006948 Genomic DNA. Translation: DAA10957.1.
PIRiS35505.
RefSeqiNP_014828.1. NM_001183604.1.

Genome annotation databases

EnsemblFungiiYOR185C; YOR185C; YOR185C.
GeneIDi854357.
KEGGisce:YOR185C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08691 Genomic DNA. Translation: AAA34654.1.
X71946 Genomic DNA. Translation: CAA50748.1.
Z75093 Genomic DNA. Translation: CAA99394.1.
AY693117 Genomic DNA. Translation: AAT93136.1.
BK006948 Genomic DNA. Translation: DAA10957.1.
PIRiS35505.
RefSeqiNP_014828.1. NM_001183604.1.

3D structure databases

ProteinModelPortaliP32836.
SMRiP32836. Positions 11-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34580. 41 interactions.
DIPiDIP-1357N.
IntActiP32836. 12 interactions.
MINTiMINT-384600.

Chemistry

BindingDBiP32836.

PTM databases

iPTMnetiP32836.

Proteomic databases

MaxQBiP32836.
PRIDEiP32836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR185C; YOR185C; YOR185C.
GeneIDi854357.
KEGGisce:YOR185C.

Organism-specific databases

EuPathDBiFungiDB:YOR185C.
SGDiS000005711. GSP2.

Phylogenomic databases

GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
InParanoidiP32836.
KOiK07936.
OMAiFRVCENI.
OrthoDBiEOG092C4F6L.

Enzyme and pathway databases

BioCyciYEAST:G3O-33695-MONOMER.
ReactomeiR-SCE-203927. MicroRNA (miRNA) biogenesis.

Miscellaneous databases

PROiP32836.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSP2_YEAST
AccessioniPrimary (citable) accession number: P32836
Secondary accession number(s): D6W2P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2460 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.