sxa1

Functionⁱ

Involved in degradation or processing of the mating pheromones. Its loss may cause a persistent response to the pheromones. It may cleave the mating pheromone M-factor. May be involved in processing of zymogens that are required for zygote formation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	94	PROSITE-ProRule annotation		1
Active siteⁱ	325	PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

aspartic-type endopeptidase activity Source: GO_Central
peptidase activity
Source: PomBase
Inferred from mutant phenotypeⁱ
- 9599405

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fungal-type cell wall organization Source: GO_Central
protein catabolic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aspartyl protease, Hydrolase, Protease

Molecular function

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A01.A91

MEROPSⁱ

A01.A91

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aspartic proteinase sxa1 (EC:3.4.23.-)
Gene namesⁱ	Name:sxa1 ORF Names:SPAC26A3.01, SPAC2E1P5.06
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome I

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC26A3.01
PomBaseⁱ	SPAC26A3.01 sxa1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000025932	24 – 533	Aspartic proteinase sxa1Add BLAST		510

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	271	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	278	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	299	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	319	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	439	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32834
PaxDbⁱ	P32834
PRIDEⁱ	P32834

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	280544, 1 interactor
STRINGⁱ	4896.SPAC26A3.01.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32834
SMRⁱ	P32834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 434	Peptidase A1PROSITE-ProRule annotationAdd BLAST		359

Sequence similaritiesⁱ

Belongs to the peptidase A1 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

InParanoidⁱ	P32834
OMAⁱ	IDHAKYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2RKK
PhylomeDBⁱ	P32834

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05471 pepsin_like, 1 hit
Gene3Dⁱ	2.40.70.10, 2 hits
InterProⁱ	View protein in InterPro IPR001461 Aspartic_peptidase_A1 IPR001969 Aspartic_peptidase_AS IPR034164 Pepsin-like_dom IPR033121 PEPTIDASE_A1 IPR021109 Peptidase_aspartic_dom_sf
PANTHERⁱ	PTHR13683 PTHR13683, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00026 Asp, 1 hit
PRINTSⁱ	PR00792 PEPSIN
SUPFAMⁱ	SSF50630 SSF50630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00141 ASP_PROTEASE, 1 hit PS51767 PEPTIDASE_A1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P32834-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKASFFVFAI SALQALQASV ASAYSEVPGK RSVVLNLQHS QYDHVARKLE 
        60         70         80         90        100
RTKVLNKRDS SGYPVLDLEY TDAGGYFANL TLGSNERVYS LTLDTGSPYT 
       110        120        130        140        150
WVTAKNITAL SASEIWSDTD GVDAGRSTSD IRTNACTNYT CFDYSSTTAR 
       160        170        180        190        200
RTNSSTIGFL ASYGDNTTVL GYNMVDNAYF AGLTLPGFEF GLATREYDSS 
       210        220        230        240        250
QISVTPGIIG LSVAMTITGI SSDDKVVAFT PPTIVDQLVS ANVIDTPAFG 
       260        270        280        290        300
IYLNEDVGEL IFGGYDKAKI NGSVHWVNIS SSDDSTFYSV NLESITVTNS 
       310        320        330        340        350
TSSNNVQSSK RSSKDIEVNT TVTLDTGTVY IYLPEDTVES IADQYQGIVS 
       360        370        380        390        400
EYGYVVIYCD SFSDSDYISF NFGSDADFHV SVNDLVIYRQ ESTSGDICYL 
       410        420        430        440        450
ALFEGDTSSY LLGQYFLQYV YSIYDWDAQK IGLAALNSNA TSTANHQILN 
       460        470        480        490        500
INSALRSVTS GQSVSATPTV SMSIAATSFG SSLVLTASAS PSSTSVDGSS 
       510        520        530 
SSDSSEASGA ASVGVSISAI VLCASTLISL LFA

Length:533

Mass (Da):56,853

Last modified:March 5, 2002 - v2

Checksum:ⁱ5B98640743D744EB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	100	T → I in BAA01046 (PubMed:1549128).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10198 Genomic DNA Translation: BAA01046.1 CU329670 Genomic DNA Translation: CAB86349.1 AB027806 Genomic DNA Translation: BAA87110.1
PIRⁱ	A42249
NCBI Reference Sequences More...RefSeqⁱ	XP_001713079.1, XM_001713027.2

Genome annotation databases

EnsemblFungiⁱ	SPAC26A3.01.1; SPAC26A3.01.1:pep; SPAC26A3.01
KEGGⁱ	spo:SPAC26A3.01

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
P32834	Aspartic protease Sxa1		SCHCR		531
Aspartic protease Sxa1		SCHOY		526

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10198 Genomic DNA Translation: BAA01046.1 CU329670 Genomic DNA Translation: CAB86349.1 AB027806 Genomic DNA Translation: BAA87110.1
PIRⁱ	A42249
NCBI Reference Sequences More...RefSeqⁱ	XP_001713079.1, XM_001713027.2

3D structure databases

ProteinModelPortalⁱ	P32834
SMRⁱ	P32834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	280544, 1 interactor
STRINGⁱ	4896.SPAC26A3.01.1

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A01.A91

MEROPSⁱ

A01.A91

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32834
PaxDbⁱ	P32834
PRIDEⁱ	P32834

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPAC26A3.01.1; SPAC26A3.01.1:pep; SPAC26A3.01
KEGGⁱ	spo:SPAC26A3.01

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC26A3.01
PomBaseⁱ	SPAC26A3.01 sxa1

Phylogenomic databases

InParanoidⁱ	P32834
OMAⁱ	IDHAKYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2RKK
PhylomeDBⁱ	P32834

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P32834

PROⁱ

PR:P32834

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05471 pepsin_like, 1 hit
Gene3Dⁱ	2.40.70.10, 2 hits
InterProⁱ	View protein in InterPro IPR001461 Aspartic_peptidase_A1 IPR001969 Aspartic_peptidase_AS IPR034164 Pepsin-like_dom IPR033121 PEPTIDASE_A1 IPR021109 Peptidase_aspartic_dom_sf
PANTHERⁱ	PTHR13683 PTHR13683, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00026 Asp, 1 hit
PRINTSⁱ	PR00792 PEPSIN
SUPFAMⁱ	SSF50630 SSF50630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00141 ASP_PROTEASE, 1 hit PS51767 PEPTIDASE_A1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SXA1_SCHPO
Accessionⁱ	P32834Primary (citable) accession number: P32834 Secondary accession number(s): Q9P7B9, Q9UU52
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	March 5, 2002
	Last modified:	May 23, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P32834 (SXA1_SCHPO)

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Aspartic proteinase sxa1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cell Wall

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ