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Protein

Aspartic proteinase sxa1

Gene

sxa1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in degradation or processing of the mating pheromones. Its loss may cause a persistent response to the pheromones. It may cleave the mating pheromone M-factor. May be involved in processing of zymogens that are required for zygote formation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94PROSITE-ProRule annotation1
Active sitei325PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: GO_Central
  • peptidase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.A91

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase sxa1 (EC:3.4.23.-)
Gene namesi
Name:sxa1
ORF Names:SPAC26A3.01, SPAC2E1P5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.01
PomBaseiSPAC26A3.01 sxa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002593224 – 533Aspartic proteinase sxa1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP32834
PaxDbiP32834
PRIDEiP32834

Interactioni

Protein-protein interaction databases

BioGridi280544, 1 interactor
STRINGi4896.SPAC26A3.01.1

Structurei

3D structure databases

ProteinModelPortaliP32834
SMRiP32834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 434Peptidase A1PROSITE-ProRule annotationAdd BLAST359

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP32834
OMAiIDHAKYT
OrthoDBiEOG092C2RKK
PhylomeDBiP32834

Family and domain databases

CDDicd05471 pepsin_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR034164 Pepsin-like_dom
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASFFVFAI SALQALQASV ASAYSEVPGK RSVVLNLQHS QYDHVARKLE
60 70 80 90 100
RTKVLNKRDS SGYPVLDLEY TDAGGYFANL TLGSNERVYS LTLDTGSPYT
110 120 130 140 150
WVTAKNITAL SASEIWSDTD GVDAGRSTSD IRTNACTNYT CFDYSSTTAR
160 170 180 190 200
RTNSSTIGFL ASYGDNTTVL GYNMVDNAYF AGLTLPGFEF GLATREYDSS
210 220 230 240 250
QISVTPGIIG LSVAMTITGI SSDDKVVAFT PPTIVDQLVS ANVIDTPAFG
260 270 280 290 300
IYLNEDVGEL IFGGYDKAKI NGSVHWVNIS SSDDSTFYSV NLESITVTNS
310 320 330 340 350
TSSNNVQSSK RSSKDIEVNT TVTLDTGTVY IYLPEDTVES IADQYQGIVS
360 370 380 390 400
EYGYVVIYCD SFSDSDYISF NFGSDADFHV SVNDLVIYRQ ESTSGDICYL
410 420 430 440 450
ALFEGDTSSY LLGQYFLQYV YSIYDWDAQK IGLAALNSNA TSTANHQILN
460 470 480 490 500
INSALRSVTS GQSVSATPTV SMSIAATSFG SSLVLTASAS PSSTSVDGSS
510 520 530
SSDSSEASGA ASVGVSISAI VLCASTLISL LFA
Length:533
Mass (Da):56,853
Last modified:March 5, 2002 - v2
Checksum:i5B98640743D744EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → I in BAA01046 (PubMed:1549128).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10198 Genomic DNA Translation: BAA01046.1
CU329670 Genomic DNA Translation: CAB86349.1
AB027806 Genomic DNA Translation: BAA87110.1
PIRiA42249
RefSeqiXP_001713079.1, XM_001713027.2

Genome annotation databases

EnsemblFungiiSPAC26A3.01.1; SPAC26A3.01.1:pep; SPAC26A3.01
KEGGispo:SPAC26A3.01

Similar proteinsi

Entry informationi

Entry nameiSXA1_SCHPO
AccessioniPrimary (citable) accession number: P32834
Secondary accession number(s): Q9P7B9, Q9UU52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 5, 2002
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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