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Protein

Serine carboxypeptidase-like 49

Gene

SCPL49

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable carboxypeptidase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei229 – 2291By similarity
Active sitei417 – 4171By similarity
Binding sitei420 – 4201SubstrateBy similarity
Active sitei474 – 4741By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciARA:AT3G10410-MONOMER.

Protein family/group databases

ESTHERiarath-SCP49. Carboxypeptidase_S10.
MEROPSiS10.A45.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase-like 49 (EC:3.4.16.-)
Gene namesi
Name:SCPL49
Ordered Locus Names:At3g10410
ORF Names:F13M14.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G10410.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • extracellular region Source: UniProtKB-SubCell
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 8260Sequence analysisPRO_0000004333Add
BLAST
Chaini83 – 516434Serine carboxypeptidase-like 49PRO_0000004334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi139 ↔ 379By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi307 ↔ 322By similarity
Disulfide bondi345 ↔ 350By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP32826.
PRIDEiP32826.

PTM databases

SwissPalmiP32826.

Expressioni

Tissue specificityi

Expressed in roots, senescent leaves and flowers.1 Publication

Gene expression databases

GenevisibleiP32826. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G10410.1.

Structurei

3D structure databases

ProteinModelPortaliP32826.
SMRiP32826. Positions 99-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198296.
InParanoidiP32826.
KOiK16298.
OMAiCERLIQN.
PhylomeDBiP32826.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLTFLSLL LHFVVFIAST IPSSSFLLND RTFERSNLPS TRAEKLIREL
60 70 80 90 100
NLFPQQDLNV IDVADLPLTA AEGPGIVERK FVFPNILADG GPTVDDLGHH
110 120 130 140 150
AGYYKLPKSR GASMFYFFFE SRNKKDAPVV IWLTGGPGCS SELAVFYENG
160 170 180 190 200
PFKITSNMSL AWNEYGWDQV SNLLYVDQPV GTGFSYTTDK SDIRHDETGV
210 220 230 240 250
SNDLYDFLQA FFAEHPKLAK NDFYITGESY AGHYIPAFAS RVHKGNKANE
260 270 280 290 300
GVHINLKGFA IGNGLTDPAL QYPAYPDYAL EMGLITQKEH DRLEKIVPLC
310 320 330 340 350
ELSIKLCGTD GTTSCLASYL VCNSLFSGVM SHAGGVNYYD IRKKCVGSLC
360 370 380 390 400
YDFSNMEKFL NLQSVRKSLG VGDIDFVSCS TSVYQAMLVD WMRNLEVGIP
410 420 430 440 450
TLLEDGISLL VYAGEYDLIC NWLGNSRWVN AMEWSGKTNF GAAKEVPFIV
460 470 480 490 500
DGKEAGLLKT YEQLSFLKVR DAGHMVPMDQ PKAALKMLKR WMENSLIEDA
510
TVTVAAQGGE ELVAQM
Length:516
Mass (Da):57,301
Last modified:May 2, 2002 - v2
Checksum:i177C778DF657A1C1
GO

Sequence cautioni

The sequence AAB04606.1 differs from that shown. Reason: Frameshift at position 515. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81130 Genomic DNA. Translation: AAB04606.1. Sequence problems.
AC011560 Genomic DNA. Translation: AAG51389.1.
CP002686 Genomic DNA. Translation: AEE74902.1.
AY091767 mRNA. Translation: AAM10315.1.
AY149954 mRNA. Translation: AAN31108.1.
Z25955 mRNA. Translation: CAA81115.1.
Z26528 mRNA. Translation: CAA81299.1.
RefSeqiNP_187652.1. NM_111876.4.
UniGeneiAt.20528.
At.45878.
At.75562.

Genome annotation databases

EnsemblPlantsiAT3G10410.1; AT3G10410.1; AT3G10410.
GeneIDi820205.
GrameneiAT3G10410.1; AT3G10410.1; AT3G10410.
KEGGiath:AT3G10410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81130 Genomic DNA. Translation: AAB04606.1. Sequence problems.
AC011560 Genomic DNA. Translation: AAG51389.1.
CP002686 Genomic DNA. Translation: AEE74902.1.
AY091767 mRNA. Translation: AAM10315.1.
AY149954 mRNA. Translation: AAN31108.1.
Z25955 mRNA. Translation: CAA81115.1.
Z26528 mRNA. Translation: CAA81299.1.
RefSeqiNP_187652.1. NM_111876.4.
UniGeneiAt.20528.
At.45878.
At.75562.

3D structure databases

ProteinModelPortaliP32826.
SMRiP32826. Positions 99-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10410.1.

Protein family/group databases

ESTHERiarath-SCP49. Carboxypeptidase_S10.
MEROPSiS10.A45.

PTM databases

SwissPalmiP32826.

Proteomic databases

PaxDbiP32826.
PRIDEiP32826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10410.1; AT3G10410.1; AT3G10410.
GeneIDi820205.
GrameneiAT3G10410.1; AT3G10410.1; AT3G10410.
KEGGiath:AT3G10410.

Organism-specific databases

TAIRiAT3G10410.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198296.
InParanoidiP32826.
KOiK16298.
OMAiCERLIQN.
PhylomeDBiP32826.

Enzyme and pathway databases

BioCyciARA:AT3G10410-MONOMER.

Miscellaneous databases

PROiP32826.

Gene expression databases

GenevisibleiP32826. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a gene encoding a carboxypeptidase Y-like protein from Arabidopsis thaliana."
    Bradley D.
    Plant Physiol. 98:1526-1529(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-372 AND 455-516.
    Strain: cv. Columbia.
    Tissue: Seedling.
  6. "An expression and bioinformatics analysis of the Arabidopsis serine carboxypeptidase-like gene family."
    Fraser C.M., Rider L.W., Chapple C.
    Plant Physiol. 138:1136-1148(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, TISSUE SPECIFICITY, NOMENCLATURE.

Entry informationi

Entry nameiSCP49_ARATH
AccessioniPrimary (citable) accession number: P32826
Secondary accession number(s): Q42107, Q9CAE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 2, 2002
Last modified: March 16, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.