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Protein

Carboxypeptidase sxa2

Gene

sxa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in degradation or processing of the mating pheromones. Its loss causes a persistent response to the pheromones. It may be required for stabilization of enzymes that are essential for zygote formation. May degrade the mating pheromone P-factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei200By similarity1
Active sitei434By similarity1
Active sitei487By similarity1

GO - Molecular functioni

  • carboxypeptidase activity Source: PomBase
  • serine-type carboxypeptidase activity Source: PomBase

GO - Biological processi

  • conjugation with cellular fusion Source: PomBase
  • negative regulation of conjugation with cellular fusion Source: PomBase
  • negative regulation of induction of conjugation with cellular fusion Source: PomBase
  • negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  • phytochelatin biosynthetic process Source: GO_Central
  • protein catabolic process in the vacuole Source: GO_Central
  • proteolysis involved in cellular protein catabolic process Source: PomBase

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERischpo-sxa2 Carboxypeptidase_S10
MEROPSiS10.012

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase sxa2 (EC:3.4.16.-)
Gene namesi
Name:sxa2
ORF Names:SPAC1296.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1296.03c
PomBaseiSPAC1296.03c sxa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000428823 – 507Carboxypeptidase sxa2Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiP32825
PRIDEiP32825

Expressioni

Inductioni

Mating pheromone signaling is required for induction.

Interactioni

Protein-protein interaction databases

BioGridi278197, 8 interactors
STRINGi4896.SPAC1296.03c.1

Structurei

3D structure databases

ProteinModelPortaliP32825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP32825
KOiK01288
OMAiYPLVEAN
OrthoDBiEOG092C2PGS
PhylomeDBiP32825

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLFLKSLF AIIIIELTII HALPTYTVHW KCSIQQANTS SASSNQTVQP
60 70 80 90 100
RQHAAPSSDR IKSLPEFKGS LPELYSGYLE ANSDKSLFYT YAPAVVDSET
110 120 130 140 150
FIVWLQGGPG CAGTLGFFSE NGPIEISQSS PSPSLNPESW TNFANMLWLD
160 170 180 190 200
QPFGTGYSQG QAAYTTTIEE ASSDFVNALK SFYQKFPHLM KKKLYLVGES
210 220 230 240 250
YGSIWSANFA EALLSEPSLN INFMGVGIVS GLTADYETQE QITASIWVEH
260 270 280 290 300
ISKLGYYFNN TSSTISEEFK KRNKECQYDS VLNRLTFPTE QYPIWRPEYN
310 320 330 340 350
FSTSTSLRKR EALDGEDIGN VFNSISGCDL YSLSNFLLYL ENSCVITYDV
360 370 380 390 400
SLDCSFNEYN DPLITYLNRE DVRSSLHATK ASTALTSGEG VFADGCNFDL
410 420 430 440 450
YKKIVSNNVE SVLVEIIPRL TEKYKVSFLA GALDLQILWT GTLLALQNTT
460 470 480 490 500
WNGWQGFTQS PGSLETTNGF TLDERNLAFT LSNSVGHMAP SKDPQMVREW

LENTLLY
Length:507
Mass (Da):56,615
Last modified:October 1, 1993 - v1
Checksum:i0BAF0A46B9E85AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10199 Genomic DNA Translation: BAA01047.1
CU329670 Genomic DNA Translation: CAB36509.1
PIRiB42249
RefSeqiNP_593043.1, NM_001018442.2

Genome annotation databases

EnsemblFungiiSPAC1296.03c.1; SPAC1296.03c.1:pep; SPAC1296.03c
GeneIDi2541701
KEGGispo:SPAC1296.03c

Similar proteinsi

Entry informationi

Entry nameiSXA2_SCHPO
AccessioniPrimary (citable) accession number: P32825
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health