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P32824

- KLKR_MASNA

UniProt

P32824 - KLKR_MASNA

Protein

Renal glandular kallikrein

Gene
N/A
Organism
Mastomys natalensis (African soft-furred rat) (Praomys natalensis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    • Comment

    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei121 – 1211Charge relay system
    Active sitei215 – 2151Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.35. 5009.

    Protein family/group databases

    MEROPSiS01.290.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renal glandular kallikrein (EC:3.4.21.35)
    Alternative name(s):
    Tissue kallikrein
    OrganismiMastomys natalensis (African soft-furred rat) (Praomys natalensis)
    Taxonomic identifieri10112 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMastomys

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027997
    Chaini25 – 263239Renal glandular kallikreinPRO_0000027998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 175PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi153 ↔ 221PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi211 ↔ 236PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP32824.
    SMRiP32824. Positions 25-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 260236Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32824-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFLILFLAL FLGGIDAAPP VQSRIIGGFN CEKNSQPWHV AVYRFARYQC    50
    GGVLLDANWV LTAAHCYNDK YQVWLGKNNR FEDEPSAQHQ LISKAIPHPG 100
    FNMSLLNKDH TPHPEDDYSN DLMLVRLKKP AEITDVVKPI DLPTEEPTVG 150
    SRCLASGWGS TTPTEEFEYS HDLQCVYLEL LSNEVCAKAH TEKVTDTMLC 200
    AGEMDGGKDT CVGDSGGPLI CDGVLQGITS WGPTPCALPN VPGIYTKLIE 250
    YRSWIKDVMA NNP 263
    Length:263
    Mass (Da):29,130
    Last modified:October 1, 1993 - v1
    Checksum:iA8EB023B800337D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17352 mRNA. Translation: CAA35232.1.
    PIRiI83227. S15686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17352 mRNA. Translation: CAA35232.1 .
    PIRi I83227. S15686.

    3D structure databases

    ProteinModelPortali P32824.
    SMRi P32824. Positions 25-263.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.290.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Enzyme and pathway databases

    BRENDAi 3.4.21.35. 5009.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of kallikrein cDNAs from the African rodent Mastomys."
      Fahnestock M.
      DNA Cell Biol. 13:293-300(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiKLKR_MASNA
    AccessioniPrimary (citable) accession number: P32824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3