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Protein

Zinc finger protein FZF1

Gene

FZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein FZF1
Alternative name(s):
Sulfite resistance protein 1
Gene namesi
Name:FZF1
Synonyms:SUL1
Ordered Locus Names:YGL254W
ORF Names:NCR299
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL254W.
SGDiS000003223. FZF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468051 – 299Zinc finger protein FZF1Add BLAST299

Proteomic databases

MaxQBiP32805.
PRIDEiP32805.

Interactioni

Protein-protein interaction databases

BioGridi33025. 26 interactors.
DIPiDIP-1324N.
IntActiP32805. 8 interactors.
MINTiMINT-402589.

Structurei

3D structure databases

ProteinModelPortaliP32805.
SMRiP32805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 107Nuclear localization signalSequence analysisAdd BLAST12

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118998.
InParanoidiP32805.
OMAiRVHKWTH.
OrthoDBiEOG092C4YPE.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG
60 70 80 90 100
KKFIRPCHLR VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL
110 120 130 140 150
ASRIDRKHEG VNANVKAELN GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD
160 170 180 190 200
DMQVLQCPYK SCQKVTSFND DLINHMLQHH IASKLVVPSG DPSLKESLPT
210 220 230 240 250
SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE SYWSDNRCKH
260 270 280 290
SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY
Length:299
Mass (Da):33,994
Last modified:October 1, 1996 - v2
Checksum:iA4E7257F012B32FF
GO

Sequence cautioni

The sequence CAA47998 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180H → D in CAA54996 (PubMed:7992510).Curated1
Sequence conflicti235T → W (PubMed:8322518).Curated1
Sequence conflicti246N → Y in CAA54996 (PubMed:7992510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti110G → E in strain: Sgu52E and Sgu52F. 1
Natural varianti120N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti228V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti238D → N in strain: MMW1-15h2 and MMW1-2h2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems.
X78104 Genomic DNA. Translation: CAA54996.1.
AY949902 Genomic DNA. Translation: AAY27304.1.
AY949903 Genomic DNA. Translation: AAY27305.1.
AY949905 Genomic DNA. Translation: AAY27307.1.
AY949906 Genomic DNA. Translation: AAY27308.1.
AY949908 Genomic DNA. Translation: AAY27310.1.
AY949909 Genomic DNA. Translation: AAY27311.1.
AY949910 Genomic DNA. Translation: AAY27312.1.
AY949911 Genomic DNA. Translation: AAY27313.1.
AY949912 Genomic DNA. Translation: AAY27314.1.
AY949913 Genomic DNA. Translation: AAY27315.1.
AY949914 Genomic DNA. Translation: AAY27316.1.
AY949915 Genomic DNA. Translation: AAY27317.1.
AY949916 Genomic DNA. Translation: AAY27318.1.
AY949917 Genomic DNA. Translation: AAY27319.1.
AY949918 Genomic DNA. Translation: AAY27320.1.
AY949919 Genomic DNA. Translation: AAY27321.1.
X94357 Genomic DNA. Translation: CAA64133.1.
Z72776 Genomic DNA. Translation: CAA96974.1.
BK006941 Genomic DNA. Translation: DAA07865.1.
PIRiS61607.
RefSeqiNP_011260.1. NM_001181120.1.

Genome annotation databases

EnsemblFungiiYGL254W; YGL254W; YGL254W.
GeneIDi852638.
KEGGisce:YGL254W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems.
X78104 Genomic DNA. Translation: CAA54996.1.
AY949902 Genomic DNA. Translation: AAY27304.1.
AY949903 Genomic DNA. Translation: AAY27305.1.
AY949905 Genomic DNA. Translation: AAY27307.1.
AY949906 Genomic DNA. Translation: AAY27308.1.
AY949908 Genomic DNA. Translation: AAY27310.1.
AY949909 Genomic DNA. Translation: AAY27311.1.
AY949910 Genomic DNA. Translation: AAY27312.1.
AY949911 Genomic DNA. Translation: AAY27313.1.
AY949912 Genomic DNA. Translation: AAY27314.1.
AY949913 Genomic DNA. Translation: AAY27315.1.
AY949914 Genomic DNA. Translation: AAY27316.1.
AY949915 Genomic DNA. Translation: AAY27317.1.
AY949916 Genomic DNA. Translation: AAY27318.1.
AY949917 Genomic DNA. Translation: AAY27319.1.
AY949918 Genomic DNA. Translation: AAY27320.1.
AY949919 Genomic DNA. Translation: AAY27321.1.
X94357 Genomic DNA. Translation: CAA64133.1.
Z72776 Genomic DNA. Translation: CAA96974.1.
BK006941 Genomic DNA. Translation: DAA07865.1.
PIRiS61607.
RefSeqiNP_011260.1. NM_001181120.1.

3D structure databases

ProteinModelPortaliP32805.
SMRiP32805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33025. 26 interactors.
DIPiDIP-1324N.
IntActiP32805. 8 interactors.
MINTiMINT-402589.

Proteomic databases

MaxQBiP32805.
PRIDEiP32805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL254W; YGL254W; YGL254W.
GeneIDi852638.
KEGGisce:YGL254W.

Organism-specific databases

EuPathDBiFungiDB:YGL254W.
SGDiS000003223. FZF1.

Phylogenomic databases

GeneTreeiENSGT00760000118998.
InParanoidiP32805.
OMAiRVHKWTH.
OrthoDBiEOG092C4YPE.

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER.

Miscellaneous databases

PROiP32805.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFZF1_YEAST
AccessioniPrimary (citable) accession number: P32805
Secondary accession number(s): D6VV81
, Q2VQB9, Q2VQC2, Q2VQC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.