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P32805

- FZF1_YEAST

UniProt

P32805 - FZF1_YEAST

Protein

Zinc finger protein FZF1

Gene

FZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May function as a transcription factor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri42 – 6625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri155 – 17925C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri246 – 27126C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD

    GO - Biological processi

    1. positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30723-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein FZF1
    Alternative name(s):
    Sulfite resistance protein 1
    Gene namesi
    Name:FZF1
    Synonyms:SUL1
    Ordered Locus Names:YGL254W
    ORF Names:NCR299
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL254w.
    SGDiS000003223. FZF1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Zinc finger protein FZF1PRO_0000046805Add
    BLAST

    Proteomic databases

    MaxQBiP32805.

    Expressioni

    Gene expression databases

    GenevestigatoriP32805.

    Interactioni

    Protein-protein interaction databases

    BioGridi33025. 25 interactions.
    DIPiDIP-1324N.
    IntActiP32805. 8 interactions.
    MINTiMINT-402589.

    Structurei

    3D structure databases

    ProteinModelPortaliP32805.
    SMRiP32805. Positions 10-179, 246-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi96 – 10712Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri42 – 6625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri155 – 17925C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri246 – 27126C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00550000074555.
    OMAiNSHERKS.
    OrthoDBiEOG751NSX.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32805-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG    50
    KKFIRPCHLR VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL 100
    ASRIDRKHEG VNANVKAELN GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD 150
    DMQVLQCPYK SCQKVTSFND DLINHMLQHH IASKLVVPSG DPSLKESLPT 200
    SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE SYWSDNRCKH 250
    SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY 299
    Length:299
    Mass (Da):33,994
    Last modified:October 1, 1996 - v2
    Checksum:iA4E7257F012B32FF
    GO

    Sequence cautioni

    The sequence CAA47998.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801H → D in CAA54996. (PubMed:7992510)Curated
    Sequence conflicti235 – 2351T → W(PubMed:8322518)Curated
    Sequence conflicti246 – 2461N → Y in CAA54996. (PubMed:7992510)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101G → E in strain: Sgu52E and Sgu52F.
    Natural varianti120 – 1201N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.
    Natural varianti228 – 2281V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.
    Natural varianti238 – 2381D → N in strain: MMW1-15h2 and MMW1-2h2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems.
    X78104 Genomic DNA. Translation: CAA54996.1.
    AY949902 Genomic DNA. Translation: AAY27304.1.
    AY949903 Genomic DNA. Translation: AAY27305.1.
    AY949905 Genomic DNA. Translation: AAY27307.1.
    AY949906 Genomic DNA. Translation: AAY27308.1.
    AY949908 Genomic DNA. Translation: AAY27310.1.
    AY949909 Genomic DNA. Translation: AAY27311.1.
    AY949910 Genomic DNA. Translation: AAY27312.1.
    AY949911 Genomic DNA. Translation: AAY27313.1.
    AY949912 Genomic DNA. Translation: AAY27314.1.
    AY949913 Genomic DNA. Translation: AAY27315.1.
    AY949914 Genomic DNA. Translation: AAY27316.1.
    AY949915 Genomic DNA. Translation: AAY27317.1.
    AY949916 Genomic DNA. Translation: AAY27318.1.
    AY949917 Genomic DNA. Translation: AAY27319.1.
    AY949918 Genomic DNA. Translation: AAY27320.1.
    AY949919 Genomic DNA. Translation: AAY27321.1.
    X94357 Genomic DNA. Translation: CAA64133.1.
    Z72776 Genomic DNA. Translation: CAA96974.1.
    BK006941 Genomic DNA. Translation: DAA07865.1.
    PIRiS61607.
    RefSeqiNP_011260.1. NM_001181120.1.

    Genome annotation databases

    EnsemblFungiiYGL254W; YGL254W; YGL254W.
    GeneIDi852638.
    KEGGisce:YGL254W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67787 Genomic DNA. Translation: CAA47998.1 . Sequence problems.
    X78104 Genomic DNA. Translation: CAA54996.1 .
    AY949902 Genomic DNA. Translation: AAY27304.1 .
    AY949903 Genomic DNA. Translation: AAY27305.1 .
    AY949905 Genomic DNA. Translation: AAY27307.1 .
    AY949906 Genomic DNA. Translation: AAY27308.1 .
    AY949908 Genomic DNA. Translation: AAY27310.1 .
    AY949909 Genomic DNA. Translation: AAY27311.1 .
    AY949910 Genomic DNA. Translation: AAY27312.1 .
    AY949911 Genomic DNA. Translation: AAY27313.1 .
    AY949912 Genomic DNA. Translation: AAY27314.1 .
    AY949913 Genomic DNA. Translation: AAY27315.1 .
    AY949914 Genomic DNA. Translation: AAY27316.1 .
    AY949915 Genomic DNA. Translation: AAY27317.1 .
    AY949916 Genomic DNA. Translation: AAY27318.1 .
    AY949917 Genomic DNA. Translation: AAY27319.1 .
    AY949918 Genomic DNA. Translation: AAY27320.1 .
    AY949919 Genomic DNA. Translation: AAY27321.1 .
    X94357 Genomic DNA. Translation: CAA64133.1 .
    Z72776 Genomic DNA. Translation: CAA96974.1 .
    BK006941 Genomic DNA. Translation: DAA07865.1 .
    PIRi S61607.
    RefSeqi NP_011260.1. NM_001181120.1.

    3D structure databases

    ProteinModelPortali P32805.
    SMRi P32805. Positions 10-179, 246-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33025. 25 interactions.
    DIPi DIP-1324N.
    IntActi P32805. 8 interactions.
    MINTi MINT-402589.

    Proteomic databases

    MaxQBi P32805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL254W ; YGL254W ; YGL254W .
    GeneIDi 852638.
    KEGGi sce:YGL254W.

    Organism-specific databases

    CYGDi YGL254w.
    SGDi S000003223. FZF1.

    Phylogenomic databases

    GeneTreei ENSGT00550000074555.
    OMAi NSHERKS.
    OrthoDBi EOG751NSX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30723-MONOMER.

    Miscellaneous databases

    NextBioi 971885.

    Gene expression databases

    Genevestigatori P32805.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae."
      Breitwieser W., Price C., Schuster T.
      Yeast 9:551-556(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 200060 / W303.
    2. "Cloning and characterization of a sulphite-resistance gene of Saccharomyces cerevisiae."
      Casalone E., Colella C.M., Daly S., Fontana S., Torricelli I., Polsinelli M.
      Yeast 10:1101-1110(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Population structure and gene evolution in Saccharomyces cerevisiae."
      Aa E., Townsend J.P., Adams R.I., Nielsen K.M., Taylor J.W.
      FEMS Yeast Res. 6:702-715(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 76625 / YPH499, MMW1-15, MMW1-15h2, MMW1-2, MMW1-2h2, Sgu52E, Sgu52F, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610.
    4. "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
      Coissac E., Maillier E., Robineau S., Netter P.
      Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFZF1_YEAST
    AccessioniPrimary (citable) accession number: P32805
    Secondary accession number(s): D6VV81
    , Q2VQB9, Q2VQC2, Q2VQC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2120 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3