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Protein

Zinc finger protein FZF1

Gene

FZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri42 – 6625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 27126C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein FZF1
Alternative name(s):
Sulfite resistance protein 1
Gene namesi
Name:FZF1
Synonyms:SUL1
Ordered Locus Names:YGL254W
ORF Names:NCR299
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGL254w.
EuPathDBiFungiDB:YGL254W.
SGDiS000003223. FZF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Zinc finger protein FZF1PRO_0000046805Add
BLAST

Proteomic databases

MaxQBiP32805.

Interactioni

Protein-protein interaction databases

BioGridi33025. 26 interactions.
DIPiDIP-1324N.
IntActiP32805. 8 interactions.
MINTiMINT-402589.
STRINGi4932.YGL254W.

Structurei

3D structure databases

ProteinModelPortaliP32805.
SMRiP32805. Positions 10-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 10712Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri42 – 6625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 27126C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00790000123549.
InParanoidiP32805.
OMAiRVHKWTH.
OrthoDBiEOG751NSX.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG
60 70 80 90 100
KKFIRPCHLR VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL
110 120 130 140 150
ASRIDRKHEG VNANVKAELN GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD
160 170 180 190 200
DMQVLQCPYK SCQKVTSFND DLINHMLQHH IASKLVVPSG DPSLKESLPT
210 220 230 240 250
SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE SYWSDNRCKH
260 270 280 290
SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY
Length:299
Mass (Da):33,994
Last modified:October 1, 1996 - v2
Checksum:iA4E7257F012B32FF
GO

Sequence cautioni

The sequence CAA47998.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801H → D in CAA54996 (PubMed:7992510).Curated
Sequence conflicti235 – 2351T → W (PubMed:8322518).Curated
Sequence conflicti246 – 2461N → Y in CAA54996 (PubMed:7992510).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101G → E in strain: Sgu52E and Sgu52F.
Natural varianti120 – 1201N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.
Natural varianti228 – 2281V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.
Natural varianti238 – 2381D → N in strain: MMW1-15h2 and MMW1-2h2.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems.
X78104 Genomic DNA. Translation: CAA54996.1.
AY949902 Genomic DNA. Translation: AAY27304.1.
AY949903 Genomic DNA. Translation: AAY27305.1.
AY949905 Genomic DNA. Translation: AAY27307.1.
AY949906 Genomic DNA. Translation: AAY27308.1.
AY949908 Genomic DNA. Translation: AAY27310.1.
AY949909 Genomic DNA. Translation: AAY27311.1.
AY949910 Genomic DNA. Translation: AAY27312.1.
AY949911 Genomic DNA. Translation: AAY27313.1.
AY949912 Genomic DNA. Translation: AAY27314.1.
AY949913 Genomic DNA. Translation: AAY27315.1.
AY949914 Genomic DNA. Translation: AAY27316.1.
AY949915 Genomic DNA. Translation: AAY27317.1.
AY949916 Genomic DNA. Translation: AAY27318.1.
AY949917 Genomic DNA. Translation: AAY27319.1.
AY949918 Genomic DNA. Translation: AAY27320.1.
AY949919 Genomic DNA. Translation: AAY27321.1.
X94357 Genomic DNA. Translation: CAA64133.1.
Z72776 Genomic DNA. Translation: CAA96974.1.
BK006941 Genomic DNA. Translation: DAA07865.1.
PIRiS61607.
RefSeqiNP_011260.1. NM_001181120.1.

Genome annotation databases

EnsemblFungiiYGL254W; YGL254W; YGL254W.
GeneIDi852638.
KEGGisce:YGL254W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems.
X78104 Genomic DNA. Translation: CAA54996.1.
AY949902 Genomic DNA. Translation: AAY27304.1.
AY949903 Genomic DNA. Translation: AAY27305.1.
AY949905 Genomic DNA. Translation: AAY27307.1.
AY949906 Genomic DNA. Translation: AAY27308.1.
AY949908 Genomic DNA. Translation: AAY27310.1.
AY949909 Genomic DNA. Translation: AAY27311.1.
AY949910 Genomic DNA. Translation: AAY27312.1.
AY949911 Genomic DNA. Translation: AAY27313.1.
AY949912 Genomic DNA. Translation: AAY27314.1.
AY949913 Genomic DNA. Translation: AAY27315.1.
AY949914 Genomic DNA. Translation: AAY27316.1.
AY949915 Genomic DNA. Translation: AAY27317.1.
AY949916 Genomic DNA. Translation: AAY27318.1.
AY949917 Genomic DNA. Translation: AAY27319.1.
AY949918 Genomic DNA. Translation: AAY27320.1.
AY949919 Genomic DNA. Translation: AAY27321.1.
X94357 Genomic DNA. Translation: CAA64133.1.
Z72776 Genomic DNA. Translation: CAA96974.1.
BK006941 Genomic DNA. Translation: DAA07865.1.
PIRiS61607.
RefSeqiNP_011260.1. NM_001181120.1.

3D structure databases

ProteinModelPortaliP32805.
SMRiP32805. Positions 10-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33025. 26 interactions.
DIPiDIP-1324N.
IntActiP32805. 8 interactions.
MINTiMINT-402589.
STRINGi4932.YGL254W.

Proteomic databases

MaxQBiP32805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL254W; YGL254W; YGL254W.
GeneIDi852638.
KEGGisce:YGL254W.

Organism-specific databases

CYGDiYGL254w.
EuPathDBiFungiDB:YGL254W.
SGDiS000003223. FZF1.

Phylogenomic databases

GeneTreeiENSGT00790000123549.
InParanoidiP32805.
OMAiRVHKWTH.
OrthoDBiEOG751NSX.

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER.

Miscellaneous databases

NextBioi971885.
PROiP32805.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae."
    Breitwieser W., Price C., Schuster T.
    Yeast 9:551-556(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 200060 / W303.
  2. "Cloning and characterization of a sulphite-resistance gene of Saccharomyces cerevisiae."
    Casalone E., Colella C.M., Daly S., Fontana S., Torricelli I., Polsinelli M.
    Yeast 10:1101-1110(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Population structure and gene evolution in Saccharomyces cerevisiae."
    Aa E., Townsend J.P., Adams R.I., Nielsen K.M., Taylor J.W.
    FEMS Yeast Res. 6:702-715(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76625 / YPH499, MMW1-15, MMW1-15h2, MMW1-2, MMW1-2h2, Sgu52E, Sgu52F, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610.
  4. "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
    Coissac E., Maillier E., Robineau S., Netter P.
    Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFZF1_YEAST
AccessioniPrimary (citable) accession number: P32805
Secondary accession number(s): D6VV81
, Q2VQB9, Q2VQC2, Q2VQC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.