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Protein

Zinc finger protein FZF1

Gene

FZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Miscellaneous

Present with 2120 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein FZF1
Alternative name(s):
Sulfite resistance protein 1
Gene namesi
Name:FZF1
Synonyms:SUL1
Ordered Locus Names:YGL254W
ORF Names:NCR299
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL254W
SGDiS000003223 FZF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468051 – 299Zinc finger protein FZF1Add BLAST299

Proteomic databases

MaxQBiP32805
PaxDbiP32805
PRIDEiP32805

Interactioni

Protein-protein interaction databases

BioGridi33025101 interactors.
DIPiDIP-1324N
IntActiP32805 8 interactors.
MINTiP32805
STRINGi4932.YGL254W

Structurei

3D structure databases

ProteinModelPortaliP32805
SMRiP32805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 107Nuclear localization signalSequence analysisAdd BLAST12

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000139443
InParanoidiP32805
OMAiRVHKWTH
OrthoDBiEOG092C4YPE

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P32805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG
60 70 80 90 100
KKFIRPCHLR VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL
110 120 130 140 150
ASRIDRKHEG VNANVKAELN GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD
160 170 180 190 200
DMQVLQCPYK SCQKVTSFND DLINHMLQHH IASKLVVPSG DPSLKESLPT
210 220 230 240 250
SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE SYWSDNRCKH
260 270 280 290
SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY
Length:299
Mass (Da):33,994
Last modified:October 1, 1996 - v2
Checksum:iA4E7257F012B32FF
GO

Sequence cautioni

The sequence CAA47998 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180H → D in CAA54996 (PubMed:7992510).Curated1
Sequence conflicti235T → W (PubMed:8322518).Curated1
Sequence conflicti246N → Y in CAA54996 (PubMed:7992510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti110G → E in strain: Sgu52E and Sgu52F. 1
Natural varianti120N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti228V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti238D → N in strain: MMW1-15h2 and MMW1-2h2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA Translation: CAA47998.1 Sequence problems.
X78104 Genomic DNA Translation: CAA54996.1
AY949902 Genomic DNA Translation: AAY27304.1
AY949903 Genomic DNA Translation: AAY27305.1
AY949905 Genomic DNA Translation: AAY27307.1
AY949906 Genomic DNA Translation: AAY27308.1
AY949908 Genomic DNA Translation: AAY27310.1
AY949909 Genomic DNA Translation: AAY27311.1
AY949910 Genomic DNA Translation: AAY27312.1
AY949911 Genomic DNA Translation: AAY27313.1
AY949912 Genomic DNA Translation: AAY27314.1
AY949913 Genomic DNA Translation: AAY27315.1
AY949914 Genomic DNA Translation: AAY27316.1
AY949915 Genomic DNA Translation: AAY27317.1
AY949916 Genomic DNA Translation: AAY27318.1
AY949917 Genomic DNA Translation: AAY27319.1
AY949918 Genomic DNA Translation: AAY27320.1
AY949919 Genomic DNA Translation: AAY27321.1
X94357 Genomic DNA Translation: CAA64133.1
Z72776 Genomic DNA Translation: CAA96974.1
BK006941 Genomic DNA Translation: DAA07865.1
PIRiS61607
RefSeqiNP_011260.1, NM_001181120.1

Genome annotation databases

EnsemblFungiiYGL254W; YGL254W; YGL254W
GeneIDi852638
KEGGisce:YGL254W

Similar proteinsi

Entry informationi

Entry nameiFZF1_YEAST
AccessioniPrimary (citable) accession number: P32805
Secondary accession number(s): D6VV81
, Q2VQB9, Q2VQC2, Q2VQC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome