Zinc finger protein FZF1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P32805 (FZF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein FZF1

Alternative name(s):
Sulfite resistance protein 1

Gene names

Name:	FZF1
Synonyms:	SUL1
Ordered Locus Names:	YGL254W
ORF Names:	NCR299

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a transcription factor.
Subcellular location	Nucleus Potential.
Miscellaneous	Present with 2120 molecules/cell in log phase SD medium.
Sequence similarities	Contains 5 C2H2-type zinc fingers.
Sequence caution	The sequence CAA47998.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 10870099. Source: SGD
Cellular_component	nucleus Inferred by curator PubMed 10234785. Source: SGD
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding Inferred from mutant phenotype PubMed 10234785. Source: SGD RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from mutant phenotype PubMed 10234785. Source: SGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 299

299

Zinc finger protein FZF1

PRO_0000046805

Regions

Zinc finger

12 – 36

C2H2-type 1

Zinc finger

42 – 66

C2H2-type 2

Zinc finger

72 – 94

C2H2-type 3

Zinc finger

155 – 179

C2H2-type 4

Zinc finger

246 – 271

C2H2-type 5

Motif

96 – 107

Nuclear localization signal Potential

Natural variations

Natural variant

110

G → E in strain: Sgu52E and Sgu52F.

Natural variant

120

N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.

Natural variant

228

V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F.

Natural variant

238

D → N in strain: MMW1-15h2 and MMW1-2h2.

Experimental info

Sequence conflict

180

H → D in CAA54996. Ref.2

Sequence conflict

235

T → W Ref.1

Sequence conflict

246

N → Y in CAA54996. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P32805 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: A4E7257F012B32FF
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FASTA

299

33,994

        10         20         30         40         50         60 
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG KKFIRPCHLR 

        70         80         90        100        110        120 
VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL ASRIDRKHEG VNANVKAELN 

       130        140        150        160        170        180 
GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD DMQVLQCPYK SCQKVTSFND DLINHMLQHH 

       190        200        210        220        230        240 
IASKLVVPSG DPSLKESLPT SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE 

       250        260        270        280        290 
SYWSDNRCKH SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae." Breitwieser W., Price C., Schuster T. Yeast 9:551-556(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 200060 / W303.
[2]	"Cloning and characterization of a sulphite-resistance gene of Saccharomyces cerevisiae." Casalone E., Colella C.M., Daly S., Fontana S., Torricelli I., Polsinelli M. Yeast 10:1101-1110(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Population structure and gene evolution in Saccharomyces cerevisiae." Aa E., Townsend J.P., Adams R.I., Nielsen K.M., Taylor J.W. FEMS Yeast Res. 6:702-715(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 76625 / YPH499, MMW1-15, MMW1-15h2, MMW1-2, MMW1-2h2, Sgu52E, Sgu52F, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610.
[4]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[5]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67787 Genomic DNA. Translation: CAA47998.1. Sequence problems. X78104 Genomic DNA. Translation: CAA54996.1. AY949902 Genomic DNA. Translation: AAY27304.1. AY949903 Genomic DNA. Translation: AAY27305.1. AY949905 Genomic DNA. Translation: AAY27307.1. AY949906 Genomic DNA. Translation: AAY27308.1. AY949908 Genomic DNA. Translation: AAY27310.1. AY949909 Genomic DNA. Translation: AAY27311.1. AY949910 Genomic DNA. Translation: AAY27312.1. AY949911 Genomic DNA. Translation: AAY27313.1. AY949912 Genomic DNA. Translation: AAY27314.1. AY949913 Genomic DNA. Translation: AAY27315.1. AY949914 Genomic DNA. Translation: AAY27316.1. AY949915 Genomic DNA. Translation: AAY27317.1. AY949916 Genomic DNA. Translation: AAY27318.1. AY949917 Genomic DNA. Translation: AAY27319.1. AY949918 Genomic DNA. Translation: AAY27320.1. AY949919 Genomic DNA. Translation: AAY27321.1. X94357 Genomic DNA. Translation: CAA64133.1. Z72776 Genomic DNA. Translation: CAA96974.1. BK006941 Genomic DNA. Translation: DAA07865.1.
PIR	S61607.
RefSeq	NP_011260.1. NM_001181120.1.
3D structure databases
ProteinModelPortal	P32805.
SMR	P32805. Positions 10-179.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1324N.
IntAct	P32805. 8 interactions.
MINT	MINT-402589.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL254W; YGL254W; YGL254W.
GeneID	852638.
KEGG	sce:YGL254W.
Organism-specific databases
CYGD	YGL254w.
SGD	S000003223. FZF1.
Phylogenomic databases
GeneTree	ENSGT00700000104705.
OMA	RVHKWTH.
OrthoDB	EOG4QG0PW.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30723-MONOMER.
Gene expression databases
ArrayExpress	P32805.
Genevestigator	P32805.
GermOnline	YGL254W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	971885.

Entry information

Entry name

FZF1_YEAST

Accession

Primary (citable) accession number: P32805
Secondary accession number(s): D6VV81

Q2VQC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents