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Protein

Zinc-regulated transporter 1

Gene

ZRT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity zinc transport protein.1 Publication

GO - Molecular functioni

  • high-affinity zinc uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • high-affinity zinc II ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30724-MONOMER.

Protein family/group databases

TCDBi2.A.5.1.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein ZRT1
Gene namesi
Name:ZRT1
Ordered Locus Names:YGL255W
ORF Names:NRC376
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL255W.
SGDiS000003224. ZRT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularSequence analysisAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 122ExtracellularSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 216CytoplasmicSequence analysisAdd BLAST73
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 242ExtracellularSequence analysis5
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 278CytoplasmicSequence analysisAdd BLAST15
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 310ExtracellularSequence analysisAdd BLAST11
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 354CytoplasmicSequence analysisAdd BLAST23
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376ExtracellularSequence analysis1

GO - Cellular componenti

  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687681 – 376Zinc-regulated transporter 1Add BLAST376

Proteomic databases

MaxQBiP32804.
PRIDEiP32804.

PTM databases

iPTMnetiP32804.

Expressioni

Inductioni

Induced in activity >100-fold in response to zinc-limiting growth conditions. Not expressed in zinc-replete cells.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33024. 118 interactors.
IntActiP32804. 1 interactor.
MINTiMINT-4486631.

Structurei

3D structure databases

ProteinModelPortaliP32804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 233Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067351.
HOGENOMiHOG000157076.
InParanoidiP32804.
KOiK14709.
OMAiTPICVAI.
OrthoDBiEOG092C357X.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.

Sequencei

Sequence statusi: Complete.

P32804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR
60 70 80 90 100
ISSVFVILFV STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF
110 120 130 140 150
IHLMDPAYGA IGGTTCVGQT GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW
160 170 180 190 200
VERKYGLSHD HTHDEIKDTV VRNTAAVSSE NDNENGTANG SHDTKNGVEY
210 220 230 240 250
YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL GSVGDEFSSL
260 270 280 290 300
YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG
310 320 330 340 350
LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK
360 370
DLRELSFNVI CTLFGAGIMA LIGKWA
Length:376
Mass (Da):41,582
Last modified:October 1, 1993 - v1
Checksum:i7A1F8367D49BAC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47997.1.
Z72777 Genomic DNA. Translation: CAA96975.1.
X94357 Genomic DNA. Translation: CAA64132.1.
BK006941 Genomic DNA. Translation: DAA07864.1.
PIRiS33654.
RefSeqiNP_011259.1. NM_001181121.1.

Genome annotation databases

EnsemblFungiiYGL255W; YGL255W; YGL255W.
GeneIDi852637.
KEGGisce:YGL255W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47997.1.
Z72777 Genomic DNA. Translation: CAA96975.1.
X94357 Genomic DNA. Translation: CAA64132.1.
BK006941 Genomic DNA. Translation: DAA07864.1.
PIRiS33654.
RefSeqiNP_011259.1. NM_001181121.1.

3D structure databases

ProteinModelPortaliP32804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33024. 118 interactors.
IntActiP32804. 1 interactor.
MINTiMINT-4486631.

Protein family/group databases

TCDBi2.A.5.1.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiP32804.

Proteomic databases

MaxQBiP32804.
PRIDEiP32804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL255W; YGL255W; YGL255W.
GeneIDi852637.
KEGGisce:YGL255W.

Organism-specific databases

EuPathDBiFungiDB:YGL255W.
SGDiS000003224. ZRT1.

Phylogenomic databases

GeneTreeiENSGT00530000067351.
HOGENOMiHOG000157076.
InParanoidiP32804.
KOiK14709.
OMAiTPICVAI.
OrthoDBiEOG092C357X.

Enzyme and pathway databases

BioCyciYEAST:G3O-30724-MONOMER.

Miscellaneous databases

PROiP32804.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZRT1_YEAST
AccessioniPrimary (citable) accession number: P32804
Secondary accession number(s): D6VV80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by Cu2+ and Fe3+ ions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.