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Protein

Zinc-regulated transporter 1

Gene

ZRT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity zinc transport protein.1 Publication

Miscellaneous

Inhibited by Cu2+ and Fe3+ ions.

GO - Molecular functioni

  • high-affinity zinc transmembrane transporter activity Source: SGD

GO - Biological processi

  • zinc ion import across plasma membrane Source: SGD

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30724-MONOMER

Protein family/group databases

TCDBi2.A.5.1.1 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein ZRT1
Gene namesi
Name:ZRT1
Ordered Locus Names:YGL255W
ORF Names:NRC376
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YGL255W
SGDiS000003224 ZRT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularSequence analysisAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 122ExtracellularSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 216CytoplasmicSequence analysisAdd BLAST73
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 242ExtracellularSequence analysis5
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 278CytoplasmicSequence analysisAdd BLAST15
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 310ExtracellularSequence analysisAdd BLAST11
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 354CytoplasmicSequence analysisAdd BLAST23
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376ExtracellularSequence analysis1

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687681 – 376Zinc-regulated transporter 1Add BLAST376

Proteomic databases

MaxQBiP32804
PaxDbiP32804
PRIDEiP32804

PTM databases

iPTMnetiP32804

Expressioni

Inductioni

Induced in activity >100-fold in response to zinc-limiting growth conditions. Not expressed in zinc-replete cells.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33024, 184 interactors
IntActiP32804, 1 interactor
STRINGi4932.YGL255W

Structurei

3D structure databases

ProteinModelPortaliP32804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 233Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067351
HOGENOMiHOG000157076
InParanoidiP32804
KOiK14709
OMAiYSWPPAI
OrthoDBiEOG092C357X

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
IPR004698 Zn/Fe_permease_fun/pln
PfamiView protein in Pfam
PF02535 Zip, 1 hit
TIGRFAMsiTIGR00820 zip, 1 hit

Sequencei

Sequence statusi: Complete.

P32804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR
60 70 80 90 100
ISSVFVILFV STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF
110 120 130 140 150
IHLMDPAYGA IGGTTCVGQT GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW
160 170 180 190 200
VERKYGLSHD HTHDEIKDTV VRNTAAVSSE NDNENGTANG SHDTKNGVEY
210 220 230 240 250
YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL GSVGDEFSSL
260 270 280 290 300
YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG
310 320 330 340 350
LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK
360 370
DLRELSFNVI CTLFGAGIMA LIGKWA
Length:376
Mass (Da):41,582
Last modified:October 1, 1993 - v1
Checksum:i7A1F8367D49BAC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA Translation: CAA47997.1
Z72777 Genomic DNA Translation: CAA96975.1
X94357 Genomic DNA Translation: CAA64132.1
BK006941 Genomic DNA Translation: DAA07864.1
PIRiS33654
RefSeqiNP_011259.1, NM_001181121.1

Genome annotation databases

EnsemblFungiiYGL255W; YGL255W; YGL255W
GeneIDi852637
KEGGisce:YGL255W

Similar proteinsi

Entry informationi

Entry nameiZRT1_YEAST
AccessioniPrimary (citable) accession number: P32804
Secondary accession number(s): D6VV80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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