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P32804 (ZRT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein ZRT1
Gene names
Name:ZRT1
Ordered Locus Names:YGL255W
ORF Names:NRC376
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity zinc transport protein. Ref.5

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Induced in activity >100-fold in response to zinc-limiting growth conditions. Not expressed in zinc-replete cells. Ref.5

Miscellaneous

Inhibited by Cu2+ and Fe3+ ions.

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandZinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhigh-affinity zinc ion transport

Inferred from mutant phenotype. Source: SGD

   Cellular componentintegral to plasma membrane

Inferred from mutant phenotype. Source: SGD

   Molecular functionhigh affinity zinc uptake transmembrane transporter activity

Inferred from mutant phenotype. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Zinc-regulated transporter 1
PRO_0000068768

Regions

Topological domain1 – 5050Extracellular Potential
Transmembrane51 – 7121Helical; Potential
Topological domain72 – 809Cytoplasmic Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 12221Extracellular Potential
Transmembrane123 – 14321Helical; Potential
Topological domain144 – 21673Cytoplasmic Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 2425Extracellular Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 27815Cytoplasmic Potential
Transmembrane279 – 29921Helical; Potential
Topological domain300 – 31011Extracellular Potential
Transmembrane311 – 33121Helical; Potential
Topological domain332 – 35423Cytoplasmic Potential
Transmembrane355 – 37521Helical; Potential
Topological domain3761Extracellular Potential
Region232 – 2332Heavy metals binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P32804 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 7A1F8367D49BAC3C

FASTA37641,582
        10         20         30         40         50         60 
MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR ISSVFVILFV 

        70         80         90        100        110        120 
STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF IHLMDPAYGA IGGTTCVGQT 

       130        140        150        160        170        180 
GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW VERKYGLSHD HTHDEIKDTV VRNTAAVSSE 

       190        200        210        220        230        240 
NDNENGTANG SHDTKNGVEY YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL 

       250        260        270        280        290        300 
GSVGDEFSSL YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG 

       310        320        330        340        350        360 
LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK DLRELSFNVI 

       370 
CTLFGAGIMA LIGKWA

« Hide

References

« Hide 'large scale' references
[1]"Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae."
Breitwieser W., Price C., Schuster T.
Yeast 9:551-556(1993) [PubMed: 8322518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 200060 / W303.
[2]"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
Coissac E., Maillier E., Robineau S., Netter P.
Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae."
Zhao H., Eide D.
J. Biol. Chem. 271:23203-23210(1996) [PubMed: 8798516] [Abstract]
Cited for: FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X67787 Genomic DNA. Translation: CAA47997.1.
Z72777 Genomic DNA. Translation: CAA96975.1.
X94357 Genomic DNA. Translation: CAA64132.1.
BK006941 Genomic DNA. Translation: DAA07864.1.
PIRS33654.
RefSeqNP_011259.1. NM_001181121.1.

3D structure databases

ProteinModelPortalP32804.
ModBaseSearch...

Protein-protein interaction databases

IntActP32804. 1 interaction.
STRINGP32804.

Protein family/group databases

TCDB2.A.5.1.1. zinc (Zn2+)-iron (Fe2+) permease (ZIP) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL255W; YGL255W; YGL255W.
GeneID852637.
KEGGsce:YGL255W.
NMPDRfig|4932.3.peg.2362.

Organism-specific databases

CYGDYGL255w.
SGDS000003224. ZRT1.

Phylogenomic databases

eggNOGfuNOG05620.
GeneTreeEFGT00050000001452.
HOGENOMHBG598807.
OMAWIAERWT.
OrthoDBEOG48H0C9.

Gene expression databases

ArrayExpressP32804.
GenevestigatorP32804.
GermOnlineYGL255W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
KOK14709.
PfamPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsTIGR00820. Zip. 1 hit.
ProtoNetSearch...

Other

NextBio971882.

Entry information

Entry nameZRT1_YEAST
AccessionPrimary (citable) accession number: P32804
Secondary accession number(s): D6VV80
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents