P32804 (ZRT1_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Zinc-regulated transporter 1 Alternative name(s): High-affinity zinc transport protein ZRT1 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | High-affinity zinc transport protein. Ref.5 |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Induction | Induced in activity >100-fold in response to zinc-limiting growth conditions. Not expressed in zinc-replete cells. Ref.5 |
| Miscellaneous | Inhibited by Cu2+ and Fe3+ ions. |
| Sequence similarities | Belongs to the ZIP transporter (TC 2.A.5) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Transport Zinc transport |
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Zinc |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | high-affinity zinc ion transport Inferred from mutant phenotype. Source: SGD |
| Cellular component | integral to plasma membrane Inferred from mutant phenotype. Source: SGD |
| Molecular function | high affinity zinc uptake transmembrane transporter activity Inferred from mutant phenotype. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 376 | 376 | Zinc-regulated transporter 1 | PRO_0000068768 | |||||
Regions | |||||||||
| Topological domain | 1 – 50 | 50 | Extracellular Potential | ||||||
| Transmembrane | 51 – 71 | 21 | Helical; Potential | ||||||
| Topological domain | 72 – 80 | 9 | Cytoplasmic Potential | ||||||
| Transmembrane | 81 – 101 | 21 | Helical; Potential | ||||||
| Topological domain | 102 – 122 | 21 | Extracellular Potential | ||||||
| Transmembrane | 123 – 143 | 21 | Helical; Potential | ||||||
| Topological domain | 144 – 216 | 73 | Cytoplasmic Potential | ||||||
| Transmembrane | 217 – 237 | 21 | Helical; Potential | ||||||
| Topological domain | 238 – 242 | 5 | Extracellular Potential | ||||||
| Transmembrane | 243 – 263 | 21 | Helical; Potential | ||||||
| Topological domain | 264 – 278 | 15 | Cytoplasmic Potential | ||||||
| Transmembrane | 279 – 299 | 21 | Helical; Potential | ||||||
| Topological domain | 300 – 310 | 11 | Extracellular Potential | ||||||
| Transmembrane | 311 – 331 | 21 | Helical; Potential | ||||||
| Topological domain | 332 – 354 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 355 – 375 | 21 | Helical; Potential | ||||||
| Topological domain | 376 | 1 | Extracellular Potential | ||||||
| Region | 232 – 233 | 2 | Heavy metals binding By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae." Breitwieser W., Price C., Schuster T. Yeast 9:551-556(1993) [PubMed: 8322518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 200060 / W303. |
| [2] | "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [3] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K.Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [4] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [5] | "The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae." Zhao H., Eide D. J. Biol. Chem. 271:23203-23210(1996) [PubMed: 8798516] [Abstract] Cited for: FUNCTION, INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X67787 Genomic DNA. Translation: CAA47997.1. Z72777 Genomic DNA. Translation: CAA96975.1. X94357 Genomic DNA. Translation: CAA64132.1. BK006941 Genomic DNA. Translation: DAA07864.1. |
| PIR | S33654. |
| RefSeq | NP_011259.1. NM_001181121.1. |
3D structure databases | |
| ProteinModelPortal | P32804. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P32804. 1 interaction. |
| STRING | P32804. |
Protein family/group databases | |
| TCDB | 2.A.5.1.1. zinc (Zn2+)-iron (Fe2+) permease (ZIP) family. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YGL255W; YGL255W; YGL255W. |
| GeneID | 852637. |
| KEGG | sce:YGL255W. |
| NMPDR | fig|4932.3.peg.2362. |
Organism-specific databases | |
| CYGD | YGL255w. |
| SGD | S000003224. ZRT1. |
Phylogenomic databases | |
| eggNOG | fuNOG05620. |
| GeneTree | EFGT00050000001452. |
| HOGENOM | HBG598807. |
| OMA | WIAERWT. |
| OrthoDB | EOG48H0C9. |
Gene expression databases | |
| ArrayExpress | P32804. |
| Genevestigator | P32804. |
| GermOnline | YGL255W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR003689. ZIP. IPR004698. Zn/Fe_permease_fun/pln. [Graphical view] |
| KO | K14709. |
| Pfam | PF02535. Zip. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00820. Zip. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 971882. |
Entry information
| Entry name | ZRT1_YEAST | ||||||||
| Accession | Primary (citable) accession number: P32804 Secondary accession number(s): D6VV80 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VII Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with