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Protein

Zinc-regulated transporter 1

Gene

ZRT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity zinc transport protein.1 Publication

GO - Molecular functioni

  • high-affinity zinc uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • high-affinity zinc II ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30724-MONOMER.

Protein family/group databases

TCDBi2.A.5.1.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein ZRT1
Gene namesi
Name:ZRT1
Ordered Locus Names:YGL255W
ORF Names:NRC376
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL255W.
SGDiS000003224. ZRT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Topological domaini72 – 809CytoplasmicSequence analysis
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Topological domaini102 – 12221ExtracellularSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 21673CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 2425ExtracellularSequence analysis
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Topological domaini264 – 27815CytoplasmicSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Topological domaini300 – 31011ExtracellularSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Topological domaini332 – 35423CytoplasmicSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 3761ExtracellularSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Zinc-regulated transporter 1PRO_0000068768Add
BLAST

Proteomic databases

MaxQBiP32804.

PTM databases

iPTMnetiP32804.

Expressioni

Inductioni

Induced in activity >100-fold in response to zinc-limiting growth conditions. Not expressed in zinc-replete cells.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33024. 117 interactions.
IntActiP32804. 1 interaction.
MINTiMINT-4486631.

Structurei

3D structure databases

ProteinModelPortaliP32804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni232 – 2332Heavy metals bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067351.
HOGENOMiHOG000157076.
InParanoidiP32804.
KOiK14709.
OMAiTANGSHD.
OrthoDBiEOG7M0P3K.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.

Sequencei

Sequence statusi: Complete.

P32804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR
60 70 80 90 100
ISSVFVILFV STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF
110 120 130 140 150
IHLMDPAYGA IGGTTCVGQT GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW
160 170 180 190 200
VERKYGLSHD HTHDEIKDTV VRNTAAVSSE NDNENGTANG SHDTKNGVEY
210 220 230 240 250
YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL GSVGDEFSSL
260 270 280 290 300
YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG
310 320 330 340 350
LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK
360 370
DLRELSFNVI CTLFGAGIMA LIGKWA
Length:376
Mass (Da):41,582
Last modified:October 1, 1993 - v1
Checksum:i7A1F8367D49BAC3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47997.1.
Z72777 Genomic DNA. Translation: CAA96975.1.
X94357 Genomic DNA. Translation: CAA64132.1.
BK006941 Genomic DNA. Translation: DAA07864.1.
PIRiS33654.
RefSeqiNP_011259.1. NM_001181121.1.

Genome annotation databases

EnsemblFungiiYGL255W; YGL255W; YGL255W.
GeneIDi852637.
KEGGisce:YGL255W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA. Translation: CAA47997.1.
Z72777 Genomic DNA. Translation: CAA96975.1.
X94357 Genomic DNA. Translation: CAA64132.1.
BK006941 Genomic DNA. Translation: DAA07864.1.
PIRiS33654.
RefSeqiNP_011259.1. NM_001181121.1.

3D structure databases

ProteinModelPortaliP32804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33024. 117 interactions.
IntActiP32804. 1 interaction.
MINTiMINT-4486631.

Protein family/group databases

TCDBi2.A.5.1.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiP32804.

Proteomic databases

MaxQBiP32804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL255W; YGL255W; YGL255W.
GeneIDi852637.
KEGGisce:YGL255W.

Organism-specific databases

EuPathDBiFungiDB:YGL255W.
SGDiS000003224. ZRT1.

Phylogenomic databases

GeneTreeiENSGT00530000067351.
HOGENOMiHOG000157076.
InParanoidiP32804.
KOiK14709.
OMAiTANGSHD.
OrthoDBiEOG7M0P3K.

Enzyme and pathway databases

BioCyciYEAST:G3O-30724-MONOMER.

Miscellaneous databases

PROiP32804.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae."
    Breitwieser W., Price C., Schuster T.
    Yeast 9:551-556(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 200060 / W303.
  2. "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
    Coissac E., Maillier E., Robineau S., Netter P.
    Yeast 12:1555-1562(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae."
    Zhao H., Eide D.
    J. Biol. Chem. 271:23203-23210(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZRT1_YEAST
AccessioniPrimary (citable) accession number: P32804
Secondary accession number(s): D6VV80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by Cu2+ and Fe3+ ions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.