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Protein

Serine/threonine-protein kinase ELM1

Gene

ELM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in G1 events required for bud emergence and septin organization. Coordinates cell growth and cell division at G2/M, essential for efficient cytokinesis and for regulation of SWE1.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117ATPPROSITE-ProRule annotation1
Active sitei259Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi94 – 102ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • budding cell bud growth Source: SGD
  • cell morphogenesis Source: SGD
  • glucose metabolic process Source: SGD
  • mitotic cytokinesis Source: SGD
  • positive regulation of protein autophosphorylation Source: SGD
  • protein autophosphorylation Source: SGD
  • protein localization to septin ring Source: SGD
  • protein phosphorylation Source: SGD
  • pseudohyphal growth Source: SGD
  • response to drug Source: SGD
  • septin ring assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31849-MONOMER.
BRENDAi2.7.10.2. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ELM1 (EC:2.7.11.1)
Gene namesi
Name:ELM1
Ordered Locus Names:YKL048C
ORF Names:YKL261
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL048C.
SGDiS000001531. ELM1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck septin ring Source: SGD
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi200T → G: Allows selective inhibition in vivo. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859511 – 640Serine/threonine-protein kinase ELM1Add BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei519PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32801.
PRIDEiP32801.

PTM databases

iPTMnetiP32801.

Interactioni

Protein-protein interaction databases

BioGridi34085. 407 interactors.
DIPiDIP-2731N.
IntActiP32801. 5 interactors.
MINTiMINT-691352.

Structurei

3D structure databases

ProteinModelPortaliP32801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 420Protein kinasePROSITE-ProRule annotationAdd BLAST333

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000066096.
InParanoidiP32801.
OMAiCIREDEL.
OrthoDBiEOG092C16EI.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRQLIPTL IPEWAPLSQQ SCIREDELDS PPITPTSQTS SFGSSFSQQK
60 70 80 90 100
PTYSTIIGEN IHTILDEIRP YVKKITVSDQ DKKTINQYTL GVSAGSGQFG
110 120 130 140 150
YVRKAYSSTL GKVVAVKIIP KKPWNAQQYS VNQVMRQIQL WKSKGKITTN
160 170 180 190 200
MSGNEAMRLM NIEKCRWEIF AASRLRNNVH IVRLIECLDS PFSESIWIVT
210 220 230 240 250
NWCSLGELQW KRDDDEDILP QWKKIVISNC SVSTFAKKIL EDMTKGLEYL
260 270 280 290 300
HSQGCIHRDI KPSNILLDEE EKVAKLSDFG SCIFTPQSLP FSDANFEDCF
310 320 330 340 350
QRELNKIVGT PAFIAPELCH LGNSKRDFVT DGFKLDIWSL GVTLYCLLYN
360 370 380 390 400
ELPFFGENEF ETYHKIIEVS LSSKINGNTL NDLVIKRLLE KDVTLRISIQ
410 420 430 440 450
DLVKVLSRDQ PIDSRNHSQI SSSSVNPVRN EGPVRRFFGR LLTKKGKKKT
460 470 480 490 500
SGKGKDKVLV SATSKVTPSI HIDEEPDKEC FSTTVLRSSP DSSDYCSSLG
510 520 530 540 550
EEAIQVTDFL DTFCRSNESL PNLTVNNDKQ NSDMKTDRSE SSSHSSLKIP
560 570 580 590 600
TPIKAMIRLK SSPKENGNRT HINCSQDKPS SPLMDRTVGK RTVNNSGARK
610 620 630 640
LAHSSNILNF KAYINSEDSD IRETVEDVKT YLNFADNGQI
Length:640
Mass (Da):72,150
Last modified:June 1, 1994 - v2
Checksum:i33C3A7E188DF12C4
GO

Sequence cautioni

The sequence AAA02892 differs from that shown. Reason: Frameshift at position 539.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti390E → Y in AAA02892 (PubMed:8395007).Curated1
Sequence conflicti484 – 485TV → SD in AAA02892 (PubMed:8395007).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81258 Unassigned DNA. Translation: AAA02892.1. Frameshift.
X71621 Genomic DNA. No translation available.
Z28048 Genomic DNA. Translation: CAA81883.1.
BK006944 Genomic DNA. Translation: DAA09109.1.
PIRiS37869.
RefSeqiNP_012876.1. NM_001179614.1.

Genome annotation databases

EnsemblFungiiYKL048C; YKL048C; YKL048C.
GeneIDi853818.
KEGGisce:YKL048C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81258 Unassigned DNA. Translation: AAA02892.1. Frameshift.
X71621 Genomic DNA. No translation available.
Z28048 Genomic DNA. Translation: CAA81883.1.
BK006944 Genomic DNA. Translation: DAA09109.1.
PIRiS37869.
RefSeqiNP_012876.1. NM_001179614.1.

3D structure databases

ProteinModelPortaliP32801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34085. 407 interactors.
DIPiDIP-2731N.
IntActiP32801. 5 interactors.
MINTiMINT-691352.

PTM databases

iPTMnetiP32801.

Proteomic databases

MaxQBiP32801.
PRIDEiP32801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL048C; YKL048C; YKL048C.
GeneIDi853818.
KEGGisce:YKL048C.

Organism-specific databases

EuPathDBiFungiDB:YKL048C.
SGDiS000001531. ELM1.

Phylogenomic databases

HOGENOMiHOG000066096.
InParanoidiP32801.
OMAiCIREDEL.
OrthoDBiEOG092C16EI.

Enzyme and pathway databases

BioCyciYEAST:G3O-31849-MONOMER.
BRENDAi2.7.10.2. 984.

Miscellaneous databases

PROiP32801.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELM1_YEAST
AccessioniPrimary (citable) accession number: P32801
Secondary accession number(s): D6VXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.