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P32800

- PEX2_YEAST

UniProt

P32800 - PEX2_YEAST

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Protein

Peroxisomal biogenesis factor 2

Gene
PEX2, CRT1, PAS5, YJL210W, HRA271, J0240
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the import of several proteins into peroxisomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 25938RING-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. ubiquitin-protein transferase activity Source: SGD

GO - Biological processi

  1. protein import into peroxisome matrix Source: SGD
  2. protein polyubiquitination Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31638-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal protein PAS5
Protein CRT1
Gene namesi
Name:PEX2
Synonyms:CRT1, PAS5
Ordered Locus Names:YJL210W
ORF Names:HRA271, J0240
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL210w.
SGDiS000003746. PEX2.

Subcellular locationi

GO - Cellular componenti

  1. peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Peroxisomal biogenesis factor 2PRO_0000030724Add
BLAST

Proteomic databases

MaxQBiP32800.
PaxDbiP32800.
PeptideAtlasiP32800.
PRIDEiP32800.

Expressioni

Gene expression databases

GenevestigatoriP32800.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX10Q0556814EBI-13160,EBI-13194
PEX13P8066710EBI-13160,EBI-13206
PEX14P5311210EBI-13160,EBI-13212

Protein-protein interaction databases

BioGridi33548. 42 interactions.
DIPiDIP-4760N.
IntActiP32800. 8 interactions.
MINTiMINT-551616.
STRINGi4932.YJL210W.

Structurei

3D structure databases

ProteinModelPortaliP32800.

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 25938RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG253452.
HOGENOMiHOG000000830.
KOiK06664.
OMAiICGTERR.
OrthoDBiEOG7GQZ6S.

Family and domain databases

InterProiIPR006845. Pex_N.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Long (identifier: P32800-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRVAQLDSI ALDKELYGQF WSEFNAAFNT SEHKEEWELA LNTVVFMCAT    50
RFLPHYGSSC TYGSALSGVV FQCRKRTLYV VTVLAGYVWK KITHIIFNGP 100
HCGNQMMWLK LYKWVNLLYH GCDVTNFLRF LAAEGPNARA FLSPLYRAFN 150
VHSTRLIRDG SAIASEFYSN SVFAGLEYQN RQLLWNALLE LFSNTLLTKR 200
GLLTFVKKPP RSRSTTTYKT VCPRCGGFPT NPYQIACCRA NYCYVCVVKA 250
LEWSMCDACG SSGRLTASPV Y 271
Length:271
Mass (Da):30,752
Last modified:October 1, 1993 - v1
Checksum:iFAEFA3A526E82F3E
GO
Isoform Short (identifier: P32800-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Show »
Length:225
Mass (Da):25,404
Checksum:i357856560BB14E33
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform Short. VSP_018874Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86538 Genomic DNA. Translation: AAB36836.1.
Z34098 Genomic DNA. Translation: CAA84000.1.
Z49486 Genomic DNA. Translation: CAA89508.1.
BK006943 Genomic DNA. Translation: DAA08600.1.
PIRiS27422.
RefSeqiNP_012325.1. NM_001181643.1. [P32800-1]

Genome annotation databases

EnsemblFungiiYJL210W; YJL210W; YJL210W. [P32800-1]
GeneIDi853219.
KEGGisce:YJL210W.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86538 Genomic DNA. Translation: AAB36836.1 .
Z34098 Genomic DNA. Translation: CAA84000.1 .
Z49486 Genomic DNA. Translation: CAA89508.1 .
BK006943 Genomic DNA. Translation: DAA08600.1 .
PIRi S27422.
RefSeqi NP_012325.1. NM_001181643.1. [P32800-1 ]

3D structure databases

ProteinModelPortali P32800.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33548. 42 interactions.
DIPi DIP-4760N.
IntActi P32800. 8 interactions.
MINTi MINT-551616.
STRINGi 4932.YJL210W.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi P32800.
PaxDbi P32800.
PeptideAtlasi P32800.
PRIDEi P32800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL210W ; YJL210W ; YJL210W . [P32800-1 ]
GeneIDi 853219.
KEGGi sce:YJL210W.

Organism-specific databases

CYGDi YJL210w.
SGDi S000003746. PEX2.

Phylogenomic databases

eggNOGi NOG253452.
HOGENOMi HOG000000830.
KOi K06664.
OMAi ICGTERR.
OrthoDBi EOG7GQZ6S.

Enzyme and pathway databases

BioCyci YEAST:G3O-31638-MONOMER.

Miscellaneous databases

NextBioi 973416.

Gene expression databases

Genevestigatori P32800.

Family and domain databases

InterProi IPR006845. Pex_N.
[Graphical view ]
Pfami PF04757. Pex2_Pex12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Independent regulation of full-length and 5'-truncated PAS5 mRNAs in Saccharomyces cerevisiae."
    Liu Y., Gu K.L., Dieckmann C.L.
    Yeast 12:135-143(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
    Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX2_YEAST
AccessioniPrimary (citable) accession number: P32800
Secondary accession number(s): D6VVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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