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P32800 (PEX2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal protein PAS5
Protein CRT1
Gene names
Name:PEX2
Synonyms:CRT1, PAS5
Ordered Locus Names:YJL210W
ORF Names:HRA271, J0240
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the import of several proteins into peroxisomes.

Subcellular location

Peroxisome.

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the pex2/pex10/pex12 family.

Contains 1 RING-type zinc finger.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform Long (identifier: P32800-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P32800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Peroxisomal biogenesis factor 2
PRO_0000030724

Regions

Zinc finger222 – 25938RING-type

Natural variations

Alternative sequence1 – 4646Missing in isoform Short.
VSP_018874

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: FAEFA3A526E82F3E

FASTA27130,752
        10         20         30         40         50         60 
MSRVAQLDSI ALDKELYGQF WSEFNAAFNT SEHKEEWELA LNTVVFMCAT RFLPHYGSSC 

        70         80         90        100        110        120 
TYGSALSGVV FQCRKRTLYV VTVLAGYVWK KITHIIFNGP HCGNQMMWLK LYKWVNLLYH 

       130        140        150        160        170        180 
GCDVTNFLRF LAAEGPNARA FLSPLYRAFN VHSTRLIRDG SAIASEFYSN SVFAGLEYQN 

       190        200        210        220        230        240 
RQLLWNALLE LFSNTLLTKR GLLTFVKKPP RSRSTTTYKT VCPRCGGFPT NPYQIACCRA 

       250        260        270 
NYCYVCVVKA LEWSMCDACG SSGRLTASPV Y 

« Hide

Isoform Short [UniParc].

Checksum: 357856560BB14E33
Show »

FASTA22525,404

References

« Hide 'large scale' references
[1]"Independent regulation of full-length and 5'-truncated PAS5 mRNAs in Saccharomyces cerevisiae."
Liu Y., Gu K.L., Dieckmann C.L.
Yeast 12:135-143(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86538 Genomic DNA. Translation: AAB36836.1.
Z34098 Genomic DNA. Translation: CAA84000.1.
Z49486 Genomic DNA. Translation: CAA89508.1.
BK006943 Genomic DNA. Translation: DAA08600.1.
PIRS27422.
RefSeqNP_012325.1. NM_001181643.1. [P32800-1]

3D structure databases

ProteinModelPortalP32800.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33548. 42 interactions.
DIPDIP-4760N.
IntActP32800. 8 interactions.
MINTMINT-551616.
STRING4932.YJL210W.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBP32800.
PaxDbP32800.
PeptideAtlasP32800.
PRIDEP32800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL210W; YJL210W; YJL210W. [P32800-1]
GeneID853219.
KEGGsce:YJL210W.

Organism-specific databases

CYGDYJL210w.
SGDS000003746. PEX2.

Phylogenomic databases

eggNOGNOG253452.
HOGENOMHOG000000830.
KOK06664.
OMAICGTERR.
OrthoDBEOG7GQZ6S.

Enzyme and pathway databases

BioCycYEAST:G3O-31638-MONOMER.

Gene expression databases

GenevestigatorP32800.

Family and domain databases

InterProIPR006845. Pex_N.
[Graphical view]
PfamPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973416.

Entry information

Entry namePEX2_YEAST
AccessionPrimary (citable) accession number: P32800
Secondary accession number(s): D6VVY4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families