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Protein

Peroxisomal biogenesis factor 2

Gene

PEX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the import of several proteins into peroxisomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 25938RING-typeAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: SGD

GO - Biological processi

  • protein import into peroxisome matrix Source: SGD
  • protein polyubiquitination Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31638-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal protein PAS5
Protein CRT1
Gene namesi
Name:PEX2
Synonyms:CRT1, PAS5
Ordered Locus Names:YJL210W
ORF Names:HRA271, J0240
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL210w.
EuPathDBiFungiDB:YJL210W.
SGDiS000003746. PEX2.

Subcellular locationi

GO - Cellular componenti

  • peroxisomal importomer complex Source: SGD
  • peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Peroxisomal biogenesis factor 2PRO_0000030724Add
BLAST

Proteomic databases

MaxQBiP32800.
PaxDbiP32800.
PeptideAtlasiP32800.
PRIDEiP32800.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX10Q0556814EBI-13160,EBI-13194
PEX13P8066710EBI-13160,EBI-13206
PEX14P5311210EBI-13160,EBI-13212

Protein-protein interaction databases

BioGridi33548. 43 interactions.
DIPiDIP-4760N.
IntActiP32800. 8 interactions.
MINTiMINT-551616.
STRINGi4932.YJL210W.

Structurei

3D structure databases

ProteinModelPortaliP32800.
SMRiP32800. Positions 218-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 25938RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG253452.
HOGENOMiHOG000000830.
InParanoidiP32800.
KOiK06664.
OMAiCCRANYC.
OrthoDBiEOG7GQZ6S.

Family and domain databases

InterProiIPR006845. Pex_N.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: P32800-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRVAQLDSI ALDKELYGQF WSEFNAAFNT SEHKEEWELA LNTVVFMCAT
60 70 80 90 100
RFLPHYGSSC TYGSALSGVV FQCRKRTLYV VTVLAGYVWK KITHIIFNGP
110 120 130 140 150
HCGNQMMWLK LYKWVNLLYH GCDVTNFLRF LAAEGPNARA FLSPLYRAFN
160 170 180 190 200
VHSTRLIRDG SAIASEFYSN SVFAGLEYQN RQLLWNALLE LFSNTLLTKR
210 220 230 240 250
GLLTFVKKPP RSRSTTTYKT VCPRCGGFPT NPYQIACCRA NYCYVCVVKA
260 270
LEWSMCDACG SSGRLTASPV Y
Length:271
Mass (Da):30,752
Last modified:October 1, 1993 - v1
Checksum:iFAEFA3A526E82F3E
GO
Isoform Short (identifier: P32800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):25,404
Checksum:i357856560BB14E33
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform Short. CuratedVSP_018874Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86538 Genomic DNA. Translation: AAB36836.1.
Z34098 Genomic DNA. Translation: CAA84000.1.
Z49486 Genomic DNA. Translation: CAA89508.1.
BK006943 Genomic DNA. Translation: DAA08600.1.
PIRiS27422.
RefSeqiNP_012325.1. NM_001181643.1. [P32800-1]

Genome annotation databases

EnsemblFungiiYJL210W; YJL210W; YJL210W. [P32800-1]
GeneIDi853219.
KEGGisce:YJL210W.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86538 Genomic DNA. Translation: AAB36836.1.
Z34098 Genomic DNA. Translation: CAA84000.1.
Z49486 Genomic DNA. Translation: CAA89508.1.
BK006943 Genomic DNA. Translation: DAA08600.1.
PIRiS27422.
RefSeqiNP_012325.1. NM_001181643.1. [P32800-1]

3D structure databases

ProteinModelPortaliP32800.
SMRiP32800. Positions 218-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33548. 43 interactions.
DIPiDIP-4760N.
IntActiP32800. 8 interactions.
MINTiMINT-551616.
STRINGi4932.YJL210W.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP32800.
PaxDbiP32800.
PeptideAtlasiP32800.
PRIDEiP32800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL210W; YJL210W; YJL210W. [P32800-1]
GeneIDi853219.
KEGGisce:YJL210W.

Organism-specific databases

CYGDiYJL210w.
EuPathDBiFungiDB:YJL210W.
SGDiS000003746. PEX2.

Phylogenomic databases

eggNOGiNOG253452.
HOGENOMiHOG000000830.
InParanoidiP32800.
KOiK06664.
OMAiCCRANYC.
OrthoDBiEOG7GQZ6S.

Enzyme and pathway databases

BioCyciYEAST:G3O-31638-MONOMER.

Miscellaneous databases

NextBioi973416.
PROiP32800.

Family and domain databases

InterProiIPR006845. Pex_N.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Independent regulation of full-length and 5'-truncated PAS5 mRNAs in Saccharomyces cerevisiae."
    Liu Y., Gu K.L., Dieckmann C.L.
    Yeast 12:135-143(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
    Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX2_YEAST
AccessioniPrimary (citable) accession number: P32800
Secondary accession number(s): D6VVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.