Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P32800

- PEX2_YEAST

UniProt

P32800 - PEX2_YEAST

Protein

Peroxisomal biogenesis factor 2

Gene

PEX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for the import of several proteins into peroxisomes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 25938RING-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. ubiquitin-protein transferase activity Source: SGD

    GO - Biological processi

    1. protein import into peroxisome matrix Source: SGD
    2. protein polyubiquitination Source: FlyBase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31638-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal biogenesis factor 2
    Alternative name(s):
    Peroxin-2
    Peroxisomal protein PAS5
    Protein CRT1
    Gene namesi
    Name:PEX2
    Synonyms:CRT1, PAS5
    Ordered Locus Names:YJL210W
    ORF Names:HRA271, J0240
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL210w.
    SGDiS000003746. PEX2.

    Subcellular locationi

    GO - Cellular componenti

    1. peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Peroxisomal biogenesis factor 2PRO_0000030724Add
    BLAST

    Proteomic databases

    MaxQBiP32800.
    PaxDbiP32800.
    PeptideAtlasiP32800.
    PRIDEiP32800.

    Expressioni

    Gene expression databases

    GenevestigatoriP32800.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX10Q0556814EBI-13160,EBI-13194
    PEX13P8066710EBI-13160,EBI-13206
    PEX14P5311210EBI-13160,EBI-13212

    Protein-protein interaction databases

    BioGridi33548. 42 interactions.
    DIPiDIP-4760N.
    IntActiP32800. 8 interactions.
    MINTiMINT-551616.
    STRINGi4932.YJL210W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32800.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pex2/pex10/pex12 family.Curated
    Contains 1 RING-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 25938RING-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG253452.
    HOGENOMiHOG000000830.
    KOiK06664.
    OMAiICGTERR.
    OrthoDBiEOG7GQZ6S.

    Family and domain databases

    InterProiIPR006845. Pex_N.
    [Graphical view]
    PfamiPF04757. Pex2_Pex12. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform Long (identifier: P32800-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRVAQLDSI ALDKELYGQF WSEFNAAFNT SEHKEEWELA LNTVVFMCAT    50
    RFLPHYGSSC TYGSALSGVV FQCRKRTLYV VTVLAGYVWK KITHIIFNGP 100
    HCGNQMMWLK LYKWVNLLYH GCDVTNFLRF LAAEGPNARA FLSPLYRAFN 150
    VHSTRLIRDG SAIASEFYSN SVFAGLEYQN RQLLWNALLE LFSNTLLTKR 200
    GLLTFVKKPP RSRSTTTYKT VCPRCGGFPT NPYQIACCRA NYCYVCVVKA 250
    LEWSMCDACG SSGRLTASPV Y 271
    Length:271
    Mass (Da):30,752
    Last modified:October 1, 1993 - v1
    Checksum:iFAEFA3A526E82F3E
    GO
    Isoform Short (identifier: P32800-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:225
    Mass (Da):25,404
    Checksum:i357856560BB14E33
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4646Missing in isoform Short. CuratedVSP_018874Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86538 Genomic DNA. Translation: AAB36836.1.
    Z34098 Genomic DNA. Translation: CAA84000.1.
    Z49486 Genomic DNA. Translation: CAA89508.1.
    BK006943 Genomic DNA. Translation: DAA08600.1.
    PIRiS27422.
    RefSeqiNP_012325.1. NM_001181643.1. [P32800-1]

    Genome annotation databases

    EnsemblFungiiYJL210W; YJL210W; YJL210W. [P32800-1]
    GeneIDi853219.
    KEGGisce:YJL210W.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86538 Genomic DNA. Translation: AAB36836.1 .
    Z34098 Genomic DNA. Translation: CAA84000.1 .
    Z49486 Genomic DNA. Translation: CAA89508.1 .
    BK006943 Genomic DNA. Translation: DAA08600.1 .
    PIRi S27422.
    RefSeqi NP_012325.1. NM_001181643.1. [P32800-1 ]

    3D structure databases

    ProteinModelPortali P32800.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33548. 42 interactions.
    DIPi DIP-4760N.
    IntActi P32800. 8 interactions.
    MINTi MINT-551616.
    STRINGi 4932.YJL210W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P32800.
    PaxDbi P32800.
    PeptideAtlasi P32800.
    PRIDEi P32800.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL210W ; YJL210W ; YJL210W . [P32800-1 ]
    GeneIDi 853219.
    KEGGi sce:YJL210W.

    Organism-specific databases

    CYGDi YJL210w.
    SGDi S000003746. PEX2.

    Phylogenomic databases

    eggNOGi NOG253452.
    HOGENOMi HOG000000830.
    KOi K06664.
    OMAi ICGTERR.
    OrthoDBi EOG7GQZ6S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31638-MONOMER.

    Miscellaneous databases

    NextBioi 973416.

    Gene expression databases

    Genevestigatori P32800.

    Family and domain databases

    InterProi IPR006845. Pex_N.
    [Graphical view ]
    Pfami PF04757. Pex2_Pex12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent regulation of full-length and 5'-truncated PAS5 mRNAs in Saccharomyces cerevisiae."
      Liu Y., Gu K.L., Dieckmann C.L.
      Yeast 12:135-143(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
      Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
      Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX2_YEAST
    AccessioniPrimary (citable) accession number: P32800
    Secondary accession number(s): D6VVY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 339 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3