Reviewed, UniProtKB/Swiss-Prot P32799 (COX13_YEAST)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 6A, mitochondrial
Alternative name(s):
    Cytochrome c oxidase polypeptide VIa

Gene names

Name:	COX13
Ordered Locus Names:	YGL191W
ORF Names:	G1341

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Not necessary for assembly of the enzyme complex but interacts with ATP and thereby modulates the enzyme activity.
Subunit structure	Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6A family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	aerobic respiration Ref.1 Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrial respiratory chain complex IV Ref.5 Inferred from physical interaction. Source: SGD
Molecular function	cytochrome-c oxidase activity Ref.5 Inferred from electronic annotation. Source: InterPro enzyme regulator activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 9	9	Mitochondrion
	Chain	10 – 129	120	Cytochrome c oxidase subunit 6A, mitochondrial		PRO_0000006127

Sequences

	Sequence		Length	Mass (Da)
	P32799-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 91C3AD6EAC23CFD3	FASTA	129	15,021
	10 20 30 40 50 60 MFRQCAKRYA SSLPPNALKP AFGPPDKVAA QKFKESLMAT EKHAKDTSNM WVKISVWVAL 70 80 90 100 110 120 PAIALTAVNT YFVEKEHAEH REHLKHVPDS EWPRDYEFMN IRSKPFFWGD GDKTLFWNPV VNRHIEHDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subunit VIa of yeast cytochrome c oxidase is not necessary for assembly of the enzyme complex but modulates the enzyme activity. Isolation and characterization of the nuclear-coded gene." Taanman J.-W., Capaldi R.A. J. Biol. Chem. 268:18754-18761(1993) [PubMed: 8395517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / GRF88.
[2]	"Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae." Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V. Yeast 13:55-64(1997) [PubMed: 9046087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme." Taanman J.-W., Capaldi R.A. J. Biol. Chem. 267:22481-22485(1992) [PubMed: 1331058] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[6]	"Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G. Eur. J. Biochem. 227:296-302(1995) [PubMed: 7851399] [Abstract] Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X72970 Genomic DNA. Translation: CAA51479.1. X91837 Genomic DNA. Translation: CAA62953.1. Z72713 Genomic DNA. Translation: CAA96903.1. AY558489 Genomic DNA. Translation: AAS56815.1.
PIR	A48520.
RefSeq	NP_011324.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P32799. 16 interactions.
Protein family/group databases
TCDB	3.D.4.8.1. proton-translocating cytochrome oxidase (COX) superfamily.
Proteomic databases
PeptideAtlas	P32799.
Genome annotation databases
Ensembl	YGL191W. Saccharomyces cerevisiae. [Contig view]
GeneID	852684.
GenomeReviews	Gene locus YGL191W in contig Y13135_GR.
KEGG	sce:YGL191W.
NMPDR	fig|4932.3.peg.2427.
Organism-specific databases
CYGD	YGL191w.
SGD	S000003159. COX13.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P32799.
OMA	P32799. HREHLKH.
Enzyme and pathway databases
BRENDA	1.9.3.1. 250.
Gene expression databases
GermOnline	YGL191W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001349. Cyt_c_oxidase_su6a. IPR018507. Cyt_c_oxidase_su6a_CS. [Graphical view]
Gene3D	G3DSA:4.10.95.10. COX6A. 1 hit.
PANTHER	PTHR11504. COX6A. 1 hit.
Pfam	PF02046. COX6A. 1 hit. [Graphical view]
PIRSF	PIRSF000277. COX6A1. 1 hit.
ProDom	PD006036. COX6A. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01329. COX6A. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	972005.

Entry information

Entry name

COX13_YEAST

Accession

Primary (citable) accession number: P32799

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)