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Protein

ATPase family gene 2 protein

Gene

AFG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not yet known. Essential for viability.

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi286 – 293ATP 1Sequence analysis8
Nucleotide bindingi557 – 564ATP 2Sequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • response to drug Source: SGD
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32461-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family gene 2 protein
Gene namesi
Name:AFG2
Ordered Locus Names:YLR397C
ORF Names:L8084.16
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR397C
SGDiS000004389 AFG2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845921 – 780ATPase family gene 2 proteinAdd BLAST780

Proteomic databases

MaxQBiP32794
PaxDbiP32794
PRIDEiP32794

Interactioni

Protein-protein interaction databases

BioGridi31656, 318 interactors
DIPiDIP-4470N
IntActiP32794, 10 interactors
MINTiP32794
STRINGi4932.YLR397C

Structurei

3D structure databases

ProteinModelPortaliP32794
SMRiP32794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00900000140994
HOGENOMiHOG000223225
InParanoidiP32794
KOiK14575
OMAiPSAMREY
OrthoDBiEOG092C0QVL

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 2 hits

Sequencei

Sequence statusi: Complete.

P32794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKSSSSGS KKKSSASSNS ADAKASKFKL PAEFITRPHP SKDHGKETCT
60 70 80 90 100
AYIHPNVLSS LEINPGSFCT VGKIGENGIL VIARAGDEEV HPVNVITLST
110 120 130 140 150
TIRSVGNLIL GDRLELKKAQ VQPPYATKVT VGSLQGYNIL ECMEEKVIQK
160 170 180 190 200
LLDDSGVIMP GMIFQNLKTK AGDESIDVVI TDASDDSLPD VSQLDLNMDD
210 220 230 240 250
MYGGLDNLFY LSPPFIFRKG STHITFSKET QANRKYNLPE PLSYAAVGGL
260 270 280 290 300
DKEIESLKSA IEIPLHQPTL FSSFGVSPPR GILLHGPPGT GKTMLLRVVA
310 320 330 340 350
NTSNAHVLTI NGPSIVSKYL GETEAALRDI FNEARKYQPS IIFIDEIDSI
360 370 380 390 400
APNRANDDSG EVESRVVATL LTLMDGMGAA GKVVVIAATN RPNSVDPALR
410 420 430 440 450
RPGRFDQEVE IGIPDVDARF DILTKQFSRM SSDRHVLDSE AIKYIASKTH
460 470 480 490 500
GYVGADLTAL CRESVMKTIQ RGLGTDANID KFSLKVTLKD VESAMVDIRP
510 520 530 540 550
SAMREIFLEM PKVYWSDIGG QEELKTKMKE MIQLPLEASE TFARLGISAP
560 570 580 590 600
KGVLLYGPPG CSKTLTAKAL ATESGINFLA VKGPEIFNKY VGESERAIRE
610 620 630 640 650
IFRKARSAAP SIIFFDEIDA LSPDRDGSST SAANHVLTSL LNEIDGVEEL
660 670 680 690 700
KGVVIVAATN RPDEIDAALL RPGRLDRHIY VGPPDVNARL EILKKCTKKF
710 720 730 740 750
NTEESGVDLH ELADRTEGYS GAEVVLLCQE AGLAAIMEDL DVAKVELRHF
760 770 780
EKAFKGIARG ITPEMLSYYE EFALRSGSSS
Length:780
Mass (Da):84,748
Last modified:October 1, 1993 - v1
Checksum:i75094DFA3D401D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14615 Unassigned DNA Translation: AAC37367.1
U19729 Genomic DNA Translation: AAB82355.1
AY693116 Genomic DNA Translation: AAT93135.1
BK006945 Genomic DNA Translation: DAA09698.1
PIRiS39110
RefSeqiNP_013501.1, NM_001182285.1

Genome annotation databases

EnsemblFungiiYLR397C; YLR397C; YLR397C
GeneIDi851113
KEGGisce:YLR397C

Similar proteinsi

Entry informationi

Entry nameiAFG2_YEAST
AccessioniPrimary (citable) accession number: P32794
Secondary accession number(s): D6VZ32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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