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Protein

Protein YSC84

Gene

YSC84

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with LSB5.1 Publication

GO - Molecular functioni

  • actin filament binding Source: SGD
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • actin cytoskeleton organization Source: SGD
  • actin filament bundle assembly Source: SGD
  • actin filament organization Source: SGD
  • endocytosis Source: SGD
  • regulation of ruffle assembly Source: GO_Central

Enzyme and pathway databases

BioCyciYEAST:G3O-31078-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YSC84
Alternative name(s):
LAS seventeen-binding protein 4
Short name:
LAS17-binding protein 4
Gene namesi
Name:YSC84
Synonyms:LSB4
Ordered Locus Names:YHR016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR016C
SGDiS000001058 YSC84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028871 – 468Protein YSC84Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32793
PaxDbiP32793
PRIDEiP32793

PTM databases

iPTMnetiP32793

Expressioni

Inductioni

Induced during sporulation.1 Publication

Interactioni

Subunit structurei

Interacts with LAS17 and SLA1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: SGD

Protein-protein interaction databases

BioGridi36445, 82 interactors
DIPiDIP-2026N
IntActiP32793, 86 interactors
MINTiP32793
STRINGi4932.YHR016C

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi413 – 418Combined sources6
Beta strandi435 – 440Combined sources6
Beta strandi447 – 453Combined sources7
Beta strandi456 – 461Combined sources6
Helixi462 – 464Combined sources3
Beta strandi465 – 467Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A08X-ray1.54A/B413-468[»]
ProteinModelPortaliP32793
SMRiP32793
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32793

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 468SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 307Asp-richAdd BLAST86

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

GeneTreeiENSGT00510000048137
HOGENOMiHOG000215564
InParanoidiP32793
KOiK20523
OMAiPPPEWAQ
OrthoDBiEOG092C3YIK

Family and domain databases

CDDicd11525 SYLF_SH3YL1_like, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR033643 SYLF_SH3YL1-like
IPR007461 Ysc84_actin-binding
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF04366 Ysc84, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P32793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGINNPIPRS LKSETKKAAK VLRSFVKPNQ VFGADQVIPP YVLKRAKGLA
60 70 80 90 100
IITVLKAGFL FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGVEL
110 120 130 140 150
TDFVFILNSE EAVRSFSEFG TITLGGNVSV SAGPLGRSAE AAASASTGGV
160 170 180 190 200
SAVFAYSKSK GLFAGVSVEG SAILERREAN RKFYGDNCTS KMILSGRVKV
210 220 230 240 250
PPAADPLLRI LESRAFNFTR HDHDDNASGD DFYDDGQYSD NTSHYYDDIP
260 270 280 290 300
DSFDSTDESS TRPNTRSSRR RGMSLGSRSR YDDDYDDDGY GRGRGYGDFD
310 320 330 340 350
SEDEDYDYGR SPNRNSSRNR GPQIDRGTKP RANTRWEDDL YDRDTEYSRP
360 370 380 390 400
NHSGRDYDNT RGNRRGYGRE RGYSLGHGPT HPSNMSNVDD LSHKMSKTGL
410 420 430 440 450
GNESTATNSA TPTAVALYNF AGEQPGDLAF KKGDVITILK KSDSQNDWWT
460
GRTNGKEGIF PANYVRVS
Length:468
Mass (Da):50,902
Last modified:April 18, 2006 - v2
Checksum:iDE42E8ECF5B83C92
GO

Sequence cautioni

The sequence AAA56990 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10400 Genomic DNA Translation: AAB68945.1
L06795 Genomic DNA Translation: AAA56990.1 Sequence problems.
BK006934 Genomic DNA Translation: DAA06705.1
PIRiS46791
RefSeqiNP_011880.1, NM_001179146.1

Genome annotation databases

EnsemblFungiiYHR016C; YHR016C; YHR016C
GeneIDi856409
KEGGisce:YHR016C

Similar proteinsi

Entry informationi

Entry nameiYSC84_YEAST
AccessioniPrimary (citable) accession number: P32793
Secondary accession number(s): D3DKW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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