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P32787 (MG101_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial genome maintenance protein MGM101
Gene names
Name:MGM101
Synonyms:MGM9
Ordered Locus Names:YJR144W
ORF Names:J2181
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA. Ref.4

Subcellular location

Mitochondrion matrixmitochondrion nucleoid Ref.4 Ref.5.

Sequence similarities

Belongs to the MGM101 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentMitochondrion
Mitochondrion nucleoid
   DomainTransit peptide
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmitochondrial genome maintenance

Inferred from electronic annotation. Source: InterPro

recombinational repair

Inferred from mutant phenotype. Source: SGD

   Cellular componentmitochondrial chromosome

Inferred from electronic annotation. Source: InterPro

   Molecular functionDNA strand annealing activity

Inferred from direct assay. Source: SGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RIM1P324451EBI-10299,EBI-15206

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion Potential
Chain31 – 269239Mitochondrial genome maintenance protein MGM101
PRO_0000021719

Sequences

Sequence LengthMass (Da)Tools
P32787 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: E14C17F2E837D6F0

FASTA26930,091
        10         20         30         40         50         60 
MKSIFKVRGC VSHAAQFCQK RTVVSTGTSN TATAGAVRKS FNSTETKPVF ATKSEAGNGS 

        70         80         90        100        110        120 
HMKEYSSGIN SKLGGTPLET RSTADDSLNN SYKQVKGDID WYTSWYGLGM KPFEAKVQKD 

       130        140        150        160        170        180 
LIEPLDPKDI EIKPDGLIYL PEIKYRRILN KAFGAGGWGL VPRSQTIVTS KLVTREYGLI 

       190        200        210        220        230        240 
CHGQLISVAR GEQDYFNEAG IPTATEGCKS NALMRCCKDL GVGSELWDPV FIKKFKVDHC 

       250        260 
TEKFVEHVTT KRKKKIWLRK DRQVEYPYK 

« Hide

References

« Hide 'large scale' references
[1]"MGM101, a nuclear gene involved in maintenance of the mitochondrial genome in Saccharomyces cerevisiae."
Chen X.-J., Guan M.-X., Clark-Walker G.D.
Nucleic Acids Res. 21:3473-3477(1993) [PubMed: 8346025] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA."
Meeusen S., Tieu Q., Wong E., Weiss E., Schieltz D., Yates J.R. III, Nunnari J.
J. Cell Biol. 145:291-304(1999) [PubMed: 10209025] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[5]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
Strain: ATCC 76625 / YPH499.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68482 Genomic DNA. Translation: CAA48502.1.
Z49644 Genomic DNA. Translation: CAA89677.1.
BK006943 Genomic DNA. Translation: DAA08929.1.
PIRS34849.
RefSeqNP_012678.1. NM_001181802.1.

3D structure databases

ProteinModelPortalP32787.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5044N.
IntActP32787. 11 interactions.
MINTMINT-511113.
STRINGP32787.

2D gel databases

UCD-2DPAGEP32787.

Proteomic databases

PeptideAtlasP32787.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJR144W; YJR144W; YJR144W.
GeneID853609.
KEGGsce:YJR144W.
NMPDRfig|4932.3.peg.3655.

Organism-specific databases

CYGDYJR144w.
SGDS000003905. MGM101.

Phylogenomic databases

eggNOGfuNOG05515.
GeneTreeEFGT00050000005714.
HOGENOMHBG448424.
OMAKLVTREY.
OrthoDBEOG4D5672.

Gene expression databases

ArrayExpressP32787.
GenevestigatorP32787.
GermOnlineYJR144W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR009446. Mgm101p.
[Graphical view]
PfamPF06420. Mgm101p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974451.

Entry information

Entry nameMG101_YEAST
AccessionPrimary (citable) accession number: P32787
Secondary accession number(s): D6VWW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families