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Protein

Mitochondrial genome maintenance protein MGM101

Gene

MGM101

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA.1 Publication

GO - Molecular functioni

  • single-stranded DNA binding Source: SGD

GO - Biological processi

  • DNA repair Source: SGD
  • DNA strand renaturation Source: SGD
  • interstrand cross-link repair Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • recombinational repair Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31758-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial genome maintenance protein MGM101
Gene namesi
Name:MGM101
Synonyms:MGM9
Ordered Locus Names:YJR144W
ORF Names:J2181
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR144W.
SGDiS000003905. MGM101.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial chromosome Source: InterPro
  • mitochondrial nucleoid Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 269239Mitochondrial genome maintenance protein MGM101PRO_0000021719Add
BLAST

Proteomic databases

MaxQBiP32787.
PeptideAtlasiP32787.

2D gel databases

UCD-2DPAGEP32787.

PTM databases

iPTMnetiP32787.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RIM1P324451EBI-10299,EBI-15206

Protein-protein interaction databases

BioGridi33900. 181 interactions.
DIPiDIP-5044N.
IntActiP32787. 8 interactions.
MINTiMINT-511113.

Structurei

3D structure databases

ProteinModelPortaliP32787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MGM101 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000214596.
InParanoidiP32787.
OrthoDBiEOG77DJH3.

Family and domain databases

InterProiIPR009446. Mgm101p.
[Graphical view]
PfamiPF06420. Mgm101p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSIFKVRGC VSHAAQFCQK RTVVSTGTSN TATAGAVRKS FNSTETKPVF
60 70 80 90 100
ATKSEAGNGS HMKEYSSGIN SKLGGTPLET RSTADDSLNN SYKQVKGDID
110 120 130 140 150
WYTSWYGLGM KPFEAKVQKD LIEPLDPKDI EIKPDGLIYL PEIKYRRILN
160 170 180 190 200
KAFGAGGWGL VPRSQTIVTS KLVTREYGLI CHGQLISVAR GEQDYFNEAG
210 220 230 240 250
IPTATEGCKS NALMRCCKDL GVGSELWDPV FIKKFKVDHC TEKFVEHVTT
260
KRKKKIWLRK DRQVEYPYK
Length:269
Mass (Da):30,091
Last modified:October 1, 1993 - v1
Checksum:iE14C17F2E837D6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68482 Genomic DNA. Translation: CAA48502.1.
Z49644 Genomic DNA. Translation: CAA89677.1.
BK006943 Genomic DNA. Translation: DAA08929.1.
PIRiS34849.
RefSeqiNP_012678.1. NM_001181802.1.

Genome annotation databases

EnsemblFungiiYJR144W; YJR144W; YJR144W.
GeneIDi853609.
KEGGisce:YJR144W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68482 Genomic DNA. Translation: CAA48502.1.
Z49644 Genomic DNA. Translation: CAA89677.1.
BK006943 Genomic DNA. Translation: DAA08929.1.
PIRiS34849.
RefSeqiNP_012678.1. NM_001181802.1.

3D structure databases

ProteinModelPortaliP32787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33900. 181 interactions.
DIPiDIP-5044N.
IntActiP32787. 8 interactions.
MINTiMINT-511113.

PTM databases

iPTMnetiP32787.

2D gel databases

UCD-2DPAGEP32787.

Proteomic databases

MaxQBiP32787.
PeptideAtlasiP32787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR144W; YJR144W; YJR144W.
GeneIDi853609.
KEGGisce:YJR144W.

Organism-specific databases

EuPathDBiFungiDB:YJR144W.
SGDiS000003905. MGM101.

Phylogenomic databases

HOGENOMiHOG000214596.
InParanoidiP32787.
OrthoDBiEOG77DJH3.

Enzyme and pathway databases

BioCyciYEAST:G3O-31758-MONOMER.

Miscellaneous databases

NextBioi974451.
PROiP32787.

Family and domain databases

InterProiIPR009446. Mgm101p.
[Graphical view]
PfamiPF06420. Mgm101p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MGM101, a nuclear gene involved in maintenance of the mitochondrial genome in Saccharomyces cerevisiae."
    Chen X.-J., Guan M.-X., Clark-Walker G.D.
    Nucleic Acids Res. 21:3473-3477(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA."
    Meeusen S., Tieu Q., Wong E., Weiss E., Schieltz D., Yates J.R. III, Nunnari J.
    J. Cell Biol. 145:291-304(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMG101_YEAST
AccessioniPrimary (citable) accession number: P32787
Secondary accession number(s): D6VWW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.