Reviewed, UniProtKB/Swiss-Prot P32782 (PDE1_CANAL)

Names and origin

Protein names

Recommended name:
    3',5'-cyclic-nucleotide phosphodiesterase
      Short name=PDEase
      Short name=3':5'-CNP
    EC=3.1.4.17

Gene names

Name:

PDE1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Sequence similarities	Belongs to the cAMP phosphodiesterase class-II family.

Ontologies

Keywords
Ligand	cAMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cAMP catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	3',5'-cyclic-nucleotide phosphodiesterase		PRO_0000206789

Sequences

	Sequence		Length	Mass (Da)
	P32782-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: A6F4581F2D2CEC75	FASTA	426	47,982
	10 20 30 40 50 60 MSFEITILGS SGGPLEGSTC SILLKPANIS YHDIINDNLP DQVLCIDAGS GMGKLTEIIH 70 80 90 100 110 120 QETTTKTSYC NFLQYYPDCE TVSYYYHPNV TITTPFSNFQ PGRPILHTQN IFNNLQNYLI 130 140 150 160 170 180 SHSHLDHVCS VVINSAGFNK NMSNKILYGS HYTINAMQQH LFNGKVWPNM PSFKIVNLNY 190 200 210 220 230 240 LESNRSERIG IYTVKMFDLS HGEFNKLTED KEDAQHHSNS NSNSNNIWGK RYDRRRSSIT 250 260 270 280 290 300 TIPQNTSGLI IKNSEALNHH YLSSAFLITL EVPCTTKEPP PSILVFGDFE SDLTSKLSRN 310 320 330 340 350 360 LFIWKSIASL ILRNQLKAIV LECSNCKEIA ANELYGHLTP KLLIYELKQL EHECKQLDTA 370 380 390 400 410 420 TTSTEQPLLG LNVIVNHVKE PIADPNQESQ LHDPRKRILA ELNKLNEIEK LGCNISIALS GTSIIV

References

[1]

"A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme." Hoyer L.L., Cieslinski L.B., McLaughlin M.M., Torphy T.J., Livi G.P., Shatzman A.R. Microbiology 140:1533-1542(1994) [PubMed: 8075796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11651 / B792 / 171D.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L12045 Genomic DNA. Translation: AAA34355.2.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.4.17. 1124.
Family and domain databases
InterPro	IPR000396. Pdiesterase2. [Graphical view]
Pfam	PF02112. PDEase_II. 1 hit. [Graphical view]
PIRSF	PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTS	PR00388. PDIESTERASE2.
ProDom	PD010003. Pdiesterase2_lac. 2 hits. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00607. PDEASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDE1_CANAL

Accession

Primary (citable) accession number: P32782

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	November 1, 1995
Last modified:	January 20, 2009
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)