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P32782 (PDE1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3',5'-cyclic-nucleotide phosphodiesterase
Short name=3':5'-CNP
Short name=PDEase
EC=3.1.4.17
Gene names
Name:PDE1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Sequence similarities

Belongs to the cAMP phosphodiesterase class-II family.

Ontologies

Keywords
   LigandcAMP
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processcAMP catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4264263',5'-cyclic-nucleotide phosphodiesterase
PRO_0000206789

Sequences

Sequence LengthMass (Da)Tools
P32782 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: A6F4581F2D2CEC75

FASTA42647,982
        10         20         30         40         50         60 
MSFEITILGS SGGPLEGSTC SILLKPANIS YHDIINDNLP DQVLCIDAGS GMGKLTEIIH 

        70         80         90        100        110        120 
QETTTKTSYC NFLQYYPDCE TVSYYYHPNV TITTPFSNFQ PGRPILHTQN IFNNLQNYLI 

       130        140        150        160        170        180 
SHSHLDHVCS VVINSAGFNK NMSNKILYGS HYTINAMQQH LFNGKVWPNM PSFKIVNLNY 

       190        200        210        220        230        240 
LESNRSERIG IYTVKMFDLS HGEFNKLTED KEDAQHHSNS NSNSNNIWGK RYDRRRSSIT 

       250        260        270        280        290        300 
TIPQNTSGLI IKNSEALNHH YLSSAFLITL EVPCTTKEPP PSILVFGDFE SDLTSKLSRN 

       310        320        330        340        350        360 
LFIWKSIASL ILRNQLKAIV LECSNCKEIA ANELYGHLTP KLLIYELKQL EHECKQLDTA 

       370        380        390        400        410        420 
TTSTEQPLLG LNVIVNHVKE PIADPNQESQ LHDPRKRILA ELNKLNEIEK LGCNISIALS 


GTSIIV

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References

[1]"A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme."
Hoyer L.L., Cieslinski L.B., McLaughlin M.M., Torphy T.J., Livi G.P., Shatzman A.R.
Microbiology 140:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 11651 / B792 / 171D.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L12045 Genomic DNA. Translation: AAA34355.2.

3D structure databases

ProteinModelPortalP32782.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5212.

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSPR00388. PDIESTERASE2.
PROSITEPS00607. PDEASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDE1_CANAX
AccessionPrimary (citable) accession number: P32782
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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