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P32780

- TF2H1_HUMAN

UniProt

P32780 - TF2H1_HUMAN

Protein

General transcription factor IIH subunit 1

Gene

GTF2H1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. 7-methylguanosine mRNA capping Source: Reactome
    2. ATP catabolic process Source: GOC
    3. DNA repair Source: Reactome
    4. gene expression Source: Reactome
    5. nucleotide-excision repair Source: Reactome
    6. nucleotide-excision repair, DNA damage removal Source: Reactome
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. positive regulation of viral transcription Source: Reactome
    9. protein phosphorylation Source: GOC
    10. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
    11. termination of RNA polymerase I transcription Source: Reactome
    12. transcription-coupled nucleotide-excision repair Source: Reactome
    13. transcription elongation from RNA polymerase II promoter Source: Reactome
    14. transcription elongation from RNA polymerase I promoter Source: Reactome
    15. transcription from RNA polymerase II promoter Source: UniProtKB
    16. transcription from RNA polymerase I promoter Source: Reactome
    17. transcription initiation from RNA polymerase II promoter Source: Reactome
    18. transcription initiation from RNA polymerase I promoter Source: Reactome
    19. viral process Source: Reactome

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1470. mRNA Capping.
    REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
    REACT_2222. Dual incision reaction in TC-NER.
    REACT_257. Formation of incision complex in GG-NER.
    REACT_311. Dual incision reaction in GG-NER.
    REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
    REACT_6233. Transcription of the HIV genome.
    REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6319. Formation of the HIV-1 Early Elongation Complex.
    REACT_6332. HIV Transcription Initiation.
    REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
    REACT_833. RNA Polymerase II Transcription Elongation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_846. Formation of the Early Elongation Complex.
    REACT_953. RNA Polymerase I Transcription Initiation.
    REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 1
    Alternative name(s):
    Basic transcription factor 2 62 kDa subunit
    Short name:
    BTF2 p62
    General transcription factor IIH polypeptide 1
    TFIIH basal transcription factor complex p62 subunit
    Gene namesi
    Name:GTF2H1
    Synonyms:BTF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:4655. GTF2H1.

    Subcellular locationi

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. holo TFIIH complex Source: UniProtKB
    3. nucleoplasm Source: Reactome
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29041.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548General transcription factor IIH subunit 1PRO_0000119245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei240 – 2401N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP32780.
    PaxDbiP32780.
    PeptideAtlasiP32780.
    PRIDEiP32780.

    PTM databases

    PhosphoSiteiP32780.

    Expressioni

    Gene expression databases

    ArrayExpressiP32780.
    BgeeiP32780.
    CleanExiHS_GTF2H1.
    GenevestigatoriP32780.

    Organism-specific databases

    HPAiCAB004637.
    HPA046660.

    Interactioni

    Subunit structurei

    One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with PUF60.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GTF2E1P2908317EBI-715539,EBI-5462215
    TP53P046375EBI-715539,EBI-366083
    XPCQ018312EBI-715539,EBI-372610

    Protein-protein interaction databases

    BioGridi109220. 51 interactions.
    DIPiDIP-708N.
    IntActiP32780. 14 interactions.
    MINTiMINT-192215.
    STRINGi9606.ENSP00000265963.

    Structurei

    Secondary structure

    1
    548
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Beta strandi8 – 136
    Beta strandi23 – 275
    Beta strandi30 – 345
    Beta strandi36 – 405
    Beta strandi42 – 465
    Turni47 – 493
    Beta strandi53 – 553
    Beta strandi58 – 625
    Beta strandi64 – 685
    Beta strandi70 – 723
    Beta strandi74 – 785
    Turni82 – 843
    Helixi87 – 10317
    Helixi109 – 12012
    Helixi122 – 13211
    Turni133 – 1353
    Helixi139 – 1468

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PFJNMR-A1-108[»]
    2DIINMR-A103-150[»]
    2RNRNMR-B1-108[»]
    ProteinModelPortaliP32780.
    SMRiP32780. Positions 1-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP32780.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini99 – 15456BSD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini180 – 23253BSD 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 BSD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG315835.
    HOGENOMiHOG000006589.
    HOVERGENiHBG060375.
    InParanoidiP32780.
    KOiK03141.
    OMAiEQNGEPS.
    OrthoDBiEOG7FV3Q4.
    PhylomeDBiP32780.
    TreeFamiTF314689.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR005607. BSD.
    IPR011993. PH_like_dom.
    IPR027079. Tfb1/p62.
    IPR013876. TFIIH_BTF_p62_N.
    [Graphical view]
    PANTHERiPTHR12856. PTHR12856. 1 hit.
    PfamiPF03909. BSD. 2 hits.
    PF08567. TFIIH_BTF_p62_N. 1 hit.
    [Graphical view]
    SMARTiSM00751. BSD. 2 hits.
    [Graphical view]
    PROSITEiPS50858. BSD. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P32780-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI    50
    KCQKISPEGK AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL 100
    PKFKRKANKE LEEKNRMLQE DPVLFQLYKD LVVSQVISAE EFWANRLNVN 150
    ATDSSSTSNH KQDVGISAAF LADVRPQTDG CNGLRYNLTS DIIESIFRTY 200
    PAVKMKYAEN VPHNMTEKEF WTRFFQSHYF HRDRLNTGSK DLFAECAKID 250
    EKGLKTMVSL GVKNPLLDLT ALEDKPLDEG YGISSVPSAS NSKSIKENSN 300
    AAIIKRFNHH SAMVLAAGLR KQEAQNEQTS EPSNMDGNSG DADCFQPAVK 350
    RAKLQESIEY EDLGKNNSVK TIALNLKKSD RYYHGPTPIQ SLQYATSQDI 400
    INSFQSIRQE MEAYTPKLTQ VLSSSAASST ITALSPGGAL MQGGTQQAIN 450
    QMVPNDIQSE LKHLYVAVGE LLRHFWSCFP VNTPFLEEKV VKMKSNLERF 500
    QVTKLCPFQE KIRRQYLSTN LVSHIEEMLQ TAYNKLHTWQ SRRLMKKT 548
    Length:548
    Mass (Da):62,032
    Last modified:October 1, 1993 - v1
    Checksum:i8F0FCEBBB1FC9C1D
    GO
    Isoform 2 (identifier: P32780-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:432
    Mass (Da):48,738
    Checksum:i894C7C56EF0407DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti292 – 2921S → P in BAB15621. (PubMed:14702039)Curated
    Sequence conflicti385 – 3851G → A in BAB15621. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti234 – 2341R → W.1 Publication
    Corresponds to variant rs4150603 [ dbSNP | Ensembl ].
    VAR_014345
    Natural varianti285 – 2851S → F.1 Publication
    Corresponds to variant rs4150636 [ dbSNP | Ensembl ].
    VAR_014346
    Natural varianti517 – 5171L → V.1 Publication
    Corresponds to variant rs4150665 [ dbSNP | Ensembl ].
    VAR_014347

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_056562Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95809 mRNA. Translation: AAA58399.1.
    AK027003 mRNA. Translation: BAB15621.1.
    AK127204 mRNA. Translation: BAG54452.1.
    AY163770 Genomic DNA. Translation: AAN46740.1.
    CR457368 mRNA. Translation: CAG33649.1.
    AC084117 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68399.1.
    CH471064 Genomic DNA. Translation: EAW68400.1.
    CH471064 Genomic DNA. Translation: EAW68401.1.
    BC000365 mRNA. Translation: AAH00365.1.
    BC004452 mRNA. Translation: AAH04452.1.
    AJ131959 Genomic DNA. Translation: CAC00685.1.
    CCDSiCCDS7838.1.
    PIRiS27958.
    RefSeqiNP_001135779.1. NM_001142307.1.
    NP_005307.1. NM_005316.3.
    XP_006718271.1. XM_006718208.1.
    UniGeneiHs.577202.

    Genome annotation databases

    EnsembliENST00000265963; ENSP00000265963; ENSG00000110768.
    ENST00000453096; ENSP00000393638; ENSG00000110768.
    ENST00000534641; ENSP00000435375; ENSG00000110768.
    GeneIDi2965.
    KEGGihsa:2965.
    UCSCiuc001moh.2. human.

    Polymorphism databases

    DMDMi416727.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95809 mRNA. Translation: AAA58399.1 .
    AK027003 mRNA. Translation: BAB15621.1 .
    AK127204 mRNA. Translation: BAG54452.1 .
    AY163770 Genomic DNA. Translation: AAN46740.1 .
    CR457368 mRNA. Translation: CAG33649.1 .
    AC084117 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68399.1 .
    CH471064 Genomic DNA. Translation: EAW68400.1 .
    CH471064 Genomic DNA. Translation: EAW68401.1 .
    BC000365 mRNA. Translation: AAH00365.1 .
    BC004452 mRNA. Translation: AAH04452.1 .
    AJ131959 Genomic DNA. Translation: CAC00685.1 .
    CCDSi CCDS7838.1.
    PIRi S27958.
    RefSeqi NP_001135779.1. NM_001142307.1.
    NP_005307.1. NM_005316.3.
    XP_006718271.1. XM_006718208.1.
    UniGenei Hs.577202.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PFJ NMR - A 1-108 [» ]
    2DII NMR - A 103-150 [» ]
    2RNR NMR - B 1-108 [» ]
    ProteinModelPortali P32780.
    SMRi P32780. Positions 1-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109220. 51 interactions.
    DIPi DIP-708N.
    IntActi P32780. 14 interactions.
    MINTi MINT-192215.
    STRINGi 9606.ENSP00000265963.

    PTM databases

    PhosphoSitei P32780.

    Polymorphism databases

    DMDMi 416727.

    Proteomic databases

    MaxQBi P32780.
    PaxDbi P32780.
    PeptideAtlasi P32780.
    PRIDEi P32780.

    Protocols and materials databases

    DNASUi 2965.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265963 ; ENSP00000265963 ; ENSG00000110768 .
    ENST00000453096 ; ENSP00000393638 ; ENSG00000110768 .
    ENST00000534641 ; ENSP00000435375 ; ENSG00000110768 .
    GeneIDi 2965.
    KEGGi hsa:2965.
    UCSCi uc001moh.2. human.

    Organism-specific databases

    CTDi 2965.
    GeneCardsi GC11P018300.
    HGNCi HGNC:4655. GTF2H1.
    HPAi CAB004637.
    HPA046660.
    MIMi 189972. gene.
    neXtProti NX_P32780.
    PharmGKBi PA29041.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315835.
    HOGENOMi HOG000006589.
    HOVERGENi HBG060375.
    InParanoidi P32780.
    KOi K03141.
    OMAi EQNGEPS.
    OrthoDBi EOG7FV3Q4.
    PhylomeDBi P32780.
    TreeFami TF314689.

    Enzyme and pathway databases

    Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1470. mRNA Capping.
    REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
    REACT_2222. Dual incision reaction in TC-NER.
    REACT_257. Formation of incision complex in GG-NER.
    REACT_311. Dual incision reaction in GG-NER.
    REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
    REACT_6233. Transcription of the HIV genome.
    REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6319. Formation of the HIV-1 Early Elongation Complex.
    REACT_6332. HIV Transcription Initiation.
    REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
    REACT_833. RNA Polymerase II Transcription Elongation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_846. Formation of the Early Elongation Complex.
    REACT_953. RNA Polymerase I Transcription Initiation.
    REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

    Miscellaneous databases

    EvolutionaryTracei P32780.
    GeneWikii GTF2H1.
    GenomeRNAii 2965.
    NextBioi 11752.
    PROi P32780.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32780.
    Bgeei P32780.
    CleanExi HS_GTF2H1.
    Genevestigatori P32780.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR005607. BSD.
    IPR011993. PH_like_dom.
    IPR027079. Tfb1/p62.
    IPR013876. TFIIH_BTF_p62_N.
    [Graphical view ]
    PANTHERi PTHR12856. PTHR12856. 1 hit.
    Pfami PF03909. BSD. 2 hits.
    PF08567. TFIIH_BTF_p62_N. 1 hit.
    [Graphical view ]
    SMARTi SM00751. BSD. 2 hits.
    [Graphical view ]
    PROSITEi PS50858. BSD. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the 62-kilodalton component of basic transcription factor BTF2."
      Fischer L., Gerard M., Chalut C., Lutz Y., Humbert S., Kanno M., Chambon P., Egly J.-M.
      Science 257:1392-1395(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Hippocampus and Liver.
    3. NIEHS SNPs program
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TRP-234; PHE-285 AND VAL-517.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. "An aphidicolin-sensitive fragile site (FRA11C) lies within 100 kb of the putative tumour suppressor gene TSG101 on both human and mouse chromosomes."
      Critcher R., Palin A.H., Zhang J., Chin S.F., Gayther S.A., Li L., Cohen S.N., Caldas C., Farr C.J.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 521-548.
    9. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."
      Kershnar E., Wu S.-Y., Chiang C.-M.
      J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TFIIH BASAL TRANSCRIPTION FACTOR.
    10. "The FBP interacting repressor targets TFIIH to inhibit activated transcription."
      Liu J., He L., Collins I., Ge H., Libutti D., Li J., Egly J.-M., Levens D.
      Mol. Cell 5:331-341(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PUF60.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of the BSD domain of human TFIIH basal transcription factor complex p62 subunit."
      RIKEN structural genomics initiative (RSGI)
      Submitted (SEP-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 103-155.

    Entry informationi

    Entry nameiTF2H1_HUMAN
    AccessioniPrimary (citable) accession number: P32780
    Secondary accession number(s): B3KXE0
    , D3DQY2, Q6I9Y7, Q9H5K5, Q9NQD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3