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Protein

1,4-alpha-glucan-branching enzyme

Gene

GLC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1230 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei356NucleophileBy similarity1
Active sitei417Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • glycogen biosynthetic process Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YEL011W-MONOMER
ReactomeiR-SCE-3322077 Glycogen synthesis
UniPathwayiUPA00164

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48
GH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan-branching enzyme (EC:2.4.1.18)
Alternative name(s):
Glycogen-branching enzyme
Gene namesi
Name:GLC3
Ordered Locus Names:YEL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL011W
SGDiS000000737 GLC3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001887861 – 7041,4-alpha-glucan-branching enzymeAdd BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32775
PaxDbiP32775
PRIDEiP32775

PTM databases

iPTMnetiP32775

Expressioni

Developmental stagei

Expressed during the transition between the late exponential and stationary growth phases, coincident with maximal glycogen accumulation.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSB1P114843EBI-7652,EBI-8627

Protein-protein interaction databases

BioGridi36720, 17 interactors
DIPiDIP-3873N
IntActiP32775, 13 interactors
MINTiP32775
STRINGi4932.YEL011W

Structurei

3D structure databases

ProteinModelPortaliP32775
SMRiP32775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000017040
HOGENOMiHOG000175159
InParanoidiP32775
KOiK00700
OMAiEVVHGKS
OrthoDBiEOG092C0QFK

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006048 A-amylase/branching_C
IPR037439 Branching_enzy
IPR006047 Glyco_hydro_13_cat_dom
IPR004193 Glyco_hydro_13_N
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PANTHERiPTHR43651 PTHR43651, 1 hit
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF02806 Alpha-amylase_C, 1 hit
PF02922 CBM_48, 1 hit
PIRSFiPIRSF000463 GlgB, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P32775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNIPDNVKG AVEFDPWLKP FADVLSERRY LADKWLYDIT HATPDGSYQS
60 70 80 90 100
LSKFARDSYK SYGLHANPET KEITYKEWAP NAERAFLVGD FNNWDTTSHE
110 120 130 140 150
LKNKDEFGNF TITLHPLPNG DFAIPHDSKI KVMFILPDGS KIFRLPAWIT
160 170 180 190 200
RATQPSKETS KQFGPAYEGR FWNPENPYKF VHPRPKFSES VDSLRIYEAH
210 220 230 240 250
VGISSPEPKI TTYKEFTEKV LPRIKYLGYD AIQLMAIMEH AYYASFGYQV
260 270 280 290 300
TNFFAASSRF GTPEELKELI DTAHSMGILV LLDVVHSHAS KNVEDGLNMF
310 320 330 340 350
DGSDHQYFHS ISSGRGEHPL WDSRLFNYGK FEVQRFLLAN LAFYVDVYQF
360 370 380 390 400
DGFRFDGVTS MLYVHHGVGA GGSFSGDYNE YLSRDRSFVD HEALAYLMLA
410 420 430 440 450
NDLVHEMLPN LAVTVAEDVS GYPTLCLPRS IGGTGFDYRL AMALPDMWIK
460 470 480 490 500
LIKEKKDDEW EMGSIVYTLT NRRYGEKVVA YCESHDQALV GDKTLAFWLM
510 520 530 540 550
DAAMYTDMTV LKEPSIVIDR GIALHKMIRL ITHSLGGEAY LNFEGNEFGH
560 570 580 590 600
PEWLDFPNVN NGDSYKYARR QFNLADDPLL RYQNLNEFDR SMQLCEKRHK
610 620 630 640 650
WLNTKQAYVS LKHEGDKMIV FERNNLLFIF NFHPTNSYSD YRVGVEKAGT
660 670 680 690 700
YHIVLNSDRA EFGGHNRINE SSEFFTTDLE WNNRKNFLQV YIPSRVALVL

ALKE
Length:704
Mass (Da):81,116
Last modified:February 1, 1995 - v2
Checksum:i9C227E107B825F27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti564S → T in AAA34632 (PubMed:1634552).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76739 Genomic DNA Translation: AAA34632.1
U18530 Genomic DNA Translation: AAB64488.1
BK006939 Genomic DNA Translation: DAA07642.1
PIRiS50448
RefSeqiNP_010905.1, NM_001178826.1

Genome annotation databases

EnsemblFungiiYEL011W; YEL011W; YEL011W
GeneIDi856705
KEGGisce:YEL011W

Similar proteinsi

Entry informationi

Entry nameiGLGB_YEAST
AccessioniPrimary (citable) accession number: P32775
Secondary accession number(s): D3DLN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health