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P32770

- NRP1_YEAST

UniProt

P32770 - NRP1_YEAST

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Protein

Asparagine-rich protein

Gene

NRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 38430RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 61030RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29559-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine-rich protein
Short name:
Protein ARP
Gene namesi
Name:NRP1
Synonyms:ARP, ARP1
Ordered Locus Names:YDL167C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL167c.
SGDiS000002326. NRP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic stress granule Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Asparagine-rich proteinPRO_0000081689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei345 – 3451Phosphoserine2 Publications
Modified residuei455 – 4551Phosphoserine2 Publications
Modified residuei630 – 6301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32770.
PaxDbiP32770.
PeptideAtlasiP32770.
PRIDEiP32770.

Expressioni

Gene expression databases

GenevestigatoriP32770.

Interactioni

Protein-protein interaction databases

BioGridi31898. 46 interactions.
DIPiDIP-5159N.
IntActiP32770. 13 interactions.
MINTiMINT-513079.
STRINGi4932.YDL167C.

Structurei

3D structure databases

ProteinModelPortaliP32770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini226 – 32297RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi490 – 56475Asn-richAdd
BLAST

Sequence similaritiesi

Contains 2 RanBP2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 38430RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 61030RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG317445.
InParanoidiP32770.
OMAiANTKQPR.
OrthoDBiEOG7NPG2Z.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32770-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHYVVLELQV AHLPDTPKDQ CRIANIAFQI VNAETLVCHY GTNSLPSIEV
60 70 80 90 100
NGTTKSLESA MVQLDKDIHD VIGNDDFVLV SLYSTWHIRV TLPRQARDDG
110 120 130 140 150
FILTSYLQHP KVFDLWKEFD RWCVNHPEIL GQKKAISNNN CNTKSISINA
160 170 180 190 200
AKNTKDLDEI VRILEVSIPT EEAGSVPEIY SLLKRTTDIL IQLHKKCTSP
210 220 230 240 250
EDMESVLTKP YDSHTDIRAF LQEKSKILYM NNLPPDTTQS ELESWFTQYG
260 270 280 290 300
VRPVGFWTVK NIVEDTSNVN NNWSLNNSPY VEDQDSISGF VVFQTHEEAT
310 320 330 340 350
EVLALNGRSI LSNLANTKQP RVVEHVLELQ PSSTGVLDKA QEILSPFPQS
360 370 380 390 400
KNKPRPGDWN CPSCGFSNFQ RRTACFRCSF PAPSNSQIHT ANSNNNVNSS
410 420 430 440 450
RNNLNNRVNS GSSSNISNTA ANHPYGAPEF NMIANNTPAA LTYNRAHFPA
460 470 480 490 500
ITPLSRQNSL NMAPSNSGSP IIIADHFSGN NNIAPNYRYN NNINNNNNNI
510 520 530 540 550
NNMTNNRYNI NNNINGNGNG NGNNSNNNNN HNNNHNNNHH NGSINSNSNT
560 570 580 590 600
NNNNNNNNGN NSNNCNSNIG MGGCGSNMPF RAGDWKCSTC TYHNFAKNVV
610 620 630 640 650
CLRCGGPKSI SGDASETNHY IDSSTFGPAS RTPSNNNISV NTNGGSNAGR
660 670 680 690 700
TDGNDNKGRD ISLMEFMSPP LSMATKSMKE GDGNGSSFNE FKSDKANVNF
710
SNVGDNSAFG NGFNSSIRW
Length:719
Mass (Da):79,299
Last modified:November 1, 1997 - v2
Checksum:iADA9BC09FD582669
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti493 – 4931I → N in CAA48159. (PubMed:8483449)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68020 Genomic DNA. Translation: CAA48159.1.
Z67750 Genomic DNA. Translation: CAA91579.1.
Z74215 Genomic DNA. Translation: CAA98741.1.
BK006938 Genomic DNA. Translation: DAA11694.1.
PIRiS61046.
RefSeqiNP_010114.1. NM_001180227.1.

Genome annotation databases

EnsemblFungiiYDL167C; YDL167C; YDL167C.
GeneIDi851387.
KEGGisce:YDL167C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68020 Genomic DNA. Translation: CAA48159.1 .
Z67750 Genomic DNA. Translation: CAA91579.1 .
Z74215 Genomic DNA. Translation: CAA98741.1 .
BK006938 Genomic DNA. Translation: DAA11694.1 .
PIRi S61046.
RefSeqi NP_010114.1. NM_001180227.1.

3D structure databases

ProteinModelPortali P32770.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31898. 46 interactions.
DIPi DIP-5159N.
IntActi P32770. 13 interactions.
MINTi MINT-513079.
STRINGi 4932.YDL167C.

Proteomic databases

MaxQBi P32770.
PaxDbi P32770.
PeptideAtlasi P32770.
PRIDEi P32770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL167C ; YDL167C ; YDL167C .
GeneIDi 851387.
KEGGi sce:YDL167C.

Organism-specific databases

CYGDi YDL167c.
SGDi S000002326. NRP1.

Phylogenomic databases

eggNOGi NOG317445.
InParanoidi P32770.
OMAi ANTKQPR.
OrthoDBi EOG7NPG2Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-29559-MONOMER.

Miscellaneous databases

NextBioi 968537.

Gene expression databases

Genevestigatori P32770.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
4.10.1060.10. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF00641. zf-RanBP. 2 hits.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular structure and genetic regulation of SFA, a gene responsible for resistance to formaldehyde in Saccharomyces cerevisiae, and characterization of its protein product."
    Wehner E.P., Rao E., Brendel M.
    Mol. Gen. Genet. 237:351-358(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 38626 / AH22 / NRRL Y-12843.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345 AND SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-630, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNRP1_YEAST
AccessioniPrimary (citable) accession number: P32770
Secondary accession number(s): D6VRI4, Q12228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3