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P32767

- KA122_YEAST

UniProt

P32767 - KA122_YEAST

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Protein

Importin beta-like protein KAP122

Gene

KAP122

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.4 Publications

GO - Molecular functioni

  1. protein transporter activity Source: SGD

GO - Biological processi

  1. protein import into nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin beta-like protein KAP122
Alternative name(s):
Karyopherin-122
Pleiotropic drug resistance regulatory protein 6
Gene namesi
Name:KAP122
Synonyms:PDR6
Ordered Locus Names:YGL016W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL016w.
SGDiS000002984. KAP122.

Subcellular locationi

Nucleus envelope 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10811081Importin beta-like protein KAP122PRO_0000058276Add
BLAST

Proteomic databases

MaxQBiP32767.
PaxDbiP32767.
PeptideAtlasiP32767.

Expressioni

Gene expression databases

GenevestigatoriP32767.

Interactioni

Subunit structurei

Associates with the nuclear pore complex (NPC). Interacts with GSP2, NUP1, NUP2, TOA1, TOA2 and WTM1.3 Publications

Protein-protein interaction databases

BioGridi33230. 90 interactions.
DIPiDIP-2449N.
IntActiP32767. 13 interactions.
MINTiMINT-707770.
STRINGi4932.YGL016W.

Structurei

3D structure databases

ProteinModelPortaliP32767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGiNOG260621.
InParanoidiP32767.
OMAiHLYISTM.
OrthoDBiEOG7XSTP0.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

P32767-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSIHEVVAL IEELYSPHPK HDVNQIQQSL QSIQKSEQGF HLANELLSDD
60 70 80 90 100
KYSANVKYFG ALTLTVQLNT RGENDYETLW NVFRSNLLYL TKFSTLYVSN
110 120 130 140 150
PNMYGQSLII IKKLMSNLSL IFTKINDPQL NNAGNENMIK QWNNPINTFI
160 170 180 190 200
QLMSVQNQNI NADQLLLDSI NCSLTYEQLS QFVSLSQKHN ELALTFTEVI
210 220 230 240 250
VEDLTKFQTK RHSMSQIHEV VHEHLYISTM ALINLNLTAQ AVFNPTVFDC
260 270 280 290 300
ITAWINYISL TRSVSSSGRM DLSEIFQNLI DLMYQSTEGS DGYENAEKIL
310 320 330 340 350
TIFGNVFAND PLLMSYDLRQ QIECIFLGVV RPDSGITDIS NKNSWMLQYM
360 370 380 390 400
NYLVTNDFFS ELKELAICIV DFLQINTLSV CNKLFTNIQA ADNGQVQDEY
410 420 430 440 450
IQEYIKVLLQ MTNFPLTPVL QEFFSVRMVD FWLDLSDAYT NLASETLRPN
460 470 480 490 500
SIELSTQIFQ QLINIYLPKI SLSVKQRIIE EEGESTSVNE FEDFRNAVSD
510 520 530 540 550
LAQSLWSILG NDNLTNVLID GMGQMPAASD ETLIIKDTDV LFRIETMCFV
560 570 580 590 600
LNTILVDMTL SESPWIKNIV DANKFFNQNV ISVFQTGFQT SASTKVSQIL
610 620 630 640 650
KLDFVRTSTT LIGTLAGYFK QEPFQLNPYV EALFQGLHTC TNFTSKNEQE
660 670 680 690 700
KISNDKLEVM VIKTVSTLCE TCREELTPYL MHFISFLNTV IMPDSNVSHF
710 720 730 740 750
TRTKLVRSIG YVVQCQVSNG PEEQAKYILQ LTNLLSGSIE HCLASSVQLQ
760 770 780 790 800
EQQDYINCLL YCISELATSL IQPTEIIEND ALLQRLSEFQ SFWSSDPLQI
810 820 830 840 850
RSKIMCTIDK VLDNSIYCKN SAFVEIGCLI VGKGLNLPDG EPYFLKYNMS
860 870 880 890 900
EVMNFVLRHV PNCELATCLP YFVYLLEKLI SEFRKELTPQ EFDFMFEKIL
910 920 930 940 950
LVYYDAYIIN DPDLLQMTIG FVNNVLDVKP GLAIGSKHWT SFILPQFLKL
960 970 980 990 1000
IPSREKFTIV AVAKFWTKLI NNKKYNQEEL TTVRQQVSSI GGDLVYQIMY
1010 1020 1030 1040 1050
GLFHTQRSDL NSYTDLLRAL VAKFPIEARE WLVAVLPQIC NNPAGHEKFI
1060 1070 1080
NKLLITRGSR AAGNVILQWW LDCTTLPNYQ G
Length:1,081
Mass (Da):123,531
Last modified:October 1, 1993 - v1
Checksum:iEEBC5ADD4E16D9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S58126 Genomic DNA. Translation: AAD13901.1.
S57895 Genomic DNA. Translation: AAB19613.1.
Z72538 Genomic DNA. Translation: CAA96716.1.
BK006941 Genomic DNA. Translation: DAA08082.1.
PIRiS15040.
RefSeqiNP_011499.1. NM_001180881.1.

Genome annotation databases

EnsemblFungiiYGL016W; YGL016W; YGL016W.
GeneIDi852868.
KEGGisce:YGL016W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S58126 Genomic DNA. Translation: AAD13901.1 .
S57895 Genomic DNA. Translation: AAB19613.1 .
Z72538 Genomic DNA. Translation: CAA96716.1 .
BK006941 Genomic DNA. Translation: DAA08082.1 .
PIRi S15040.
RefSeqi NP_011499.1. NM_001180881.1.

3D structure databases

ProteinModelPortali P32767.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33230. 90 interactions.
DIPi DIP-2449N.
IntActi P32767. 13 interactions.
MINTi MINT-707770.
STRINGi 4932.YGL016W.

Proteomic databases

MaxQBi P32767.
PaxDbi P32767.
PeptideAtlasi P32767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL016W ; YGL016W ; YGL016W .
GeneIDi 852868.
KEGGi sce:YGL016W.

Organism-specific databases

CYGDi YGL016w.
SGDi S000002984. KAP122.

Phylogenomic databases

eggNOGi NOG260621.
InParanoidi P32767.
OMAi HLYISTM.
OrthoDBi EOG7XSTP0.

Enzyme and pathway databases

BioCyci YEAST:G3O-30537-MONOMER.

Miscellaneous databases

NextBioi 972490.

Gene expression databases

Genevestigatori P32767.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance."
    Chen W., Balzi E., Capieaux E., Choder M., Goffeau A.
    Yeast 7:287-299(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 46191 / IL125-2B.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus."
    Titov A.A., Blobel G.
    J. Cell Biol. 147:235-246(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NUP1; NUP2; TOA1 AND TOA2, FUNCTION.
  5. "Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p."
    Lau D., Kunzler M., Braunwarth A., Hellmuth K., Podtelejnikov A., Mann M., Hurt E.
    J. Biol. Chem. 275:467-471(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GSP2.
  6. "The yeast nuclear pore complex: composition, architecture, and transport mechanism."
    Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.
    J. Cell Biol. 148:635-651(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ASSOCIATION WITH THE NUCLEAR PORE COMPLEX.
  7. "Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein."
    Zhang Z., An X., Yang K., Perlstein D.L., Hicks L., Kelleher N., Stubbe J., Huang M.
    Proc. Natl. Acad. Sci. U.S.A. 103:1422-1427(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH WTM1.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit."
    Wu X., Huang M.
    Mol. Cell. Biol. 28:7156-7167(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKA122_YEAST
AccessioniPrimary (citable) accession number: P32767
Secondary accession number(s): D6VUC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9760 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3