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Protein

Importin beta-like protein KAP122

Gene

KAP122

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.4 Publications

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • protein transporter activity Source: SGD

GO - Biological processi

  • protein import into nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin beta-like protein KAP122
Alternative name(s):
Karyopherin-122
Pleiotropic drug resistance regulatory protein 6
Gene namesi
Name:KAP122
Synonyms:PDR6
Ordered Locus Names:YGL016W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL016W.
SGDiS000002984. KAP122.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nuclear membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582761 – 1081Importin beta-like protein KAP122Add BLAST1081

Proteomic databases

MaxQBiP32767.
PRIDEiP32767.

Interactioni

Subunit structurei

Associates with the nuclear pore complex (NPC). Interacts with GSP2, NUP1, NUP2, TOA1, TOA2 and WTM1.3 Publications

Protein-protein interaction databases

BioGridi33230. 91 interactors.
DIPiDIP-2449N.
IntActiP32767. 13 interactors.
MINTiMINT-707770.

Structurei

3D structure databases

ProteinModelPortaliP32767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

InParanoidiP32767.
OMAiHEHLYIS.
OrthoDBiEOG092C0997.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

P32767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIHEVVAL IEELYSPHPK HDVNQIQQSL QSIQKSEQGF HLANELLSDD
60 70 80 90 100
KYSANVKYFG ALTLTVQLNT RGENDYETLW NVFRSNLLYL TKFSTLYVSN
110 120 130 140 150
PNMYGQSLII IKKLMSNLSL IFTKINDPQL NNAGNENMIK QWNNPINTFI
160 170 180 190 200
QLMSVQNQNI NADQLLLDSI NCSLTYEQLS QFVSLSQKHN ELALTFTEVI
210 220 230 240 250
VEDLTKFQTK RHSMSQIHEV VHEHLYISTM ALINLNLTAQ AVFNPTVFDC
260 270 280 290 300
ITAWINYISL TRSVSSSGRM DLSEIFQNLI DLMYQSTEGS DGYENAEKIL
310 320 330 340 350
TIFGNVFAND PLLMSYDLRQ QIECIFLGVV RPDSGITDIS NKNSWMLQYM
360 370 380 390 400
NYLVTNDFFS ELKELAICIV DFLQINTLSV CNKLFTNIQA ADNGQVQDEY
410 420 430 440 450
IQEYIKVLLQ MTNFPLTPVL QEFFSVRMVD FWLDLSDAYT NLASETLRPN
460 470 480 490 500
SIELSTQIFQ QLINIYLPKI SLSVKQRIIE EEGESTSVNE FEDFRNAVSD
510 520 530 540 550
LAQSLWSILG NDNLTNVLID GMGQMPAASD ETLIIKDTDV LFRIETMCFV
560 570 580 590 600
LNTILVDMTL SESPWIKNIV DANKFFNQNV ISVFQTGFQT SASTKVSQIL
610 620 630 640 650
KLDFVRTSTT LIGTLAGYFK QEPFQLNPYV EALFQGLHTC TNFTSKNEQE
660 670 680 690 700
KISNDKLEVM VIKTVSTLCE TCREELTPYL MHFISFLNTV IMPDSNVSHF
710 720 730 740 750
TRTKLVRSIG YVVQCQVSNG PEEQAKYILQ LTNLLSGSIE HCLASSVQLQ
760 770 780 790 800
EQQDYINCLL YCISELATSL IQPTEIIEND ALLQRLSEFQ SFWSSDPLQI
810 820 830 840 850
RSKIMCTIDK VLDNSIYCKN SAFVEIGCLI VGKGLNLPDG EPYFLKYNMS
860 870 880 890 900
EVMNFVLRHV PNCELATCLP YFVYLLEKLI SEFRKELTPQ EFDFMFEKIL
910 920 930 940 950
LVYYDAYIIN DPDLLQMTIG FVNNVLDVKP GLAIGSKHWT SFILPQFLKL
960 970 980 990 1000
IPSREKFTIV AVAKFWTKLI NNKKYNQEEL TTVRQQVSSI GGDLVYQIMY
1010 1020 1030 1040 1050
GLFHTQRSDL NSYTDLLRAL VAKFPIEARE WLVAVLPQIC NNPAGHEKFI
1060 1070 1080
NKLLITRGSR AAGNVILQWW LDCTTLPNYQ G
Length:1,081
Mass (Da):123,531
Last modified:October 1, 1993 - v1
Checksum:iEEBC5ADD4E16D9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S58126 Genomic DNA. Translation: AAD13901.1.
S57895 Genomic DNA. Translation: AAB19613.1.
Z72538 Genomic DNA. Translation: CAA96716.1.
BK006941 Genomic DNA. Translation: DAA08082.1.
PIRiS15040.
RefSeqiNP_011499.1. NM_001180881.1.

Genome annotation databases

EnsemblFungiiYGL016W; YGL016W; YGL016W.
GeneIDi852868.
KEGGisce:YGL016W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S58126 Genomic DNA. Translation: AAD13901.1.
S57895 Genomic DNA. Translation: AAB19613.1.
Z72538 Genomic DNA. Translation: CAA96716.1.
BK006941 Genomic DNA. Translation: DAA08082.1.
PIRiS15040.
RefSeqiNP_011499.1. NM_001180881.1.

3D structure databases

ProteinModelPortaliP32767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33230. 91 interactors.
DIPiDIP-2449N.
IntActiP32767. 13 interactors.
MINTiMINT-707770.

Proteomic databases

MaxQBiP32767.
PRIDEiP32767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL016W; YGL016W; YGL016W.
GeneIDi852868.
KEGGisce:YGL016W.

Organism-specific databases

EuPathDBiFungiDB:YGL016W.
SGDiS000002984. KAP122.

Phylogenomic databases

InParanoidiP32767.
OMAiHEHLYIS.
OrthoDBiEOG092C0997.

Enzyme and pathway databases

BioCyciYEAST:G3O-30537-MONOMER.

Miscellaneous databases

PROiP32767.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKA122_YEAST
AccessioniPrimary (citable) accession number: P32767
Secondary accession number(s): D6VUC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9760 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.