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Protein

Cystatin-8

Gene

Cst8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Performs a specialized role during sperm development and maturation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-8
Alternative name(s):
Cystatin-related epididymal spermatogenic protein
Cystatin-related epididymal-specific protein
Gene namesi
Name:Cst8
Synonyms:Cres
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107161. Cst8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000665420 – 142Cystatin-8Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 105By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 139By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32766.
PRIDEiP32766.

PTM databases

PhosphoSitePlusiP32766.

Expressioni

Tissue specificityi

Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.

Inductioni

Testicular factors or hormones other than androgens present in the testicular fluid may be involved in the regulation of CRES gene expression.

Gene expression databases

BgeeiENSMUSG00000027442.
GenevisibleiP32766. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028931.

Structurei

3D structure databases

ProteinModelPortaliP32766.
SMRiP32766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 81Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXH4. Eukaryota.
ENOG41113F6. LUCA.
GeneTreeiENSGT00900000141055.
HOGENOMiHOG000231754.
HOVERGENiHBG095685.
InParanoidiP32766.
KOiK13904.
OMAiKQCLWFA.
OrthoDBiEOG091G0TP1.
PhylomeDBiP32766.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPLWLSLI LFIIPVALAV GVDQSKNEVK AQNYFGSINI SNANVKQCVW
60 70 80 90 100
FAMKEYNKES EDKYVFLVDK ILHAKLQITD RMEYQIDVQI SRSNCKKPLN
110 120 130 140
NTENCIPQKK PELEKKMSCS FLVGALPWNG EFNLLSKECK DV
Length:142
Mass (Da):16,288
Last modified:May 30, 2000 - v2
Checksum:i50B446E98F66673E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 15PLWLS…LFIIP → GTRDEQVGESQK in AAC35390 (PubMed:1280328).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091503 Genomic DNA. Translation: AAC61754.1.
AK018943 mRNA. Translation: BAB31489.1.
AK054409 mRNA. Translation: BAC35768.1.
AK161808 mRNA. Translation: BAE36585.1.
BC049753 mRNA. Translation: AAH49753.1.
AF090691 mRNA. Translation: AAC36316.1.
S49926 mRNA. Translation: AAC35390.1.
CCDSiCCDS16848.1.
PIRiA45361.
RefSeqiNP_034108.1. NM_009978.2.
XP_006498721.1. XM_006498658.3.
XP_006498722.1. XM_006498659.3.
UniGeneiMm.20435.

Genome annotation databases

EnsembliENSMUST00000028931; ENSMUSP00000028931; ENSMUSG00000027442.
ENSMUST00000109947; ENSMUSP00000105573; ENSMUSG00000027442.
GeneIDi13012.
KEGGimmu:13012.
UCSCiuc008mto.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCST8_MOUSE
AccessioniPrimary (citable) accession number: P32766
Secondary accession number(s): O89102, Q543A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 30, 2000
Last modified: October 25, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families