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P32756 (CLAT_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline O-acetyltransferase

Short name=CHOACTase
Short name=ChAT
Short name=Choline acetylase
EC=2.3.1.6
Gene names
Name:cha-1
ORF Names:ZC416.8
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

Catalytic activity

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Choline O-acetyltransferase
PRO_0000210153

Regions

Region418 – 43013Coenzyme A binding By similarity

Sites

Active site3411Proton acceptor By similarity
Binding site4561Coenzyme A By similarity
Binding site5591Coenzyme A By similarity

Sequences

Sequence LengthMass (Da)Tools
P32756 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 59F52175E6F16494

FASTA62771,317
        10         20         30         40         50         60 
MEKEKVDELP PNDNWYETAL PKPPVPSLEA TLDRYLEYAA VVAVGQKASL ATTHDAAHKF 

        70         80         90        100        110        120 
VRQATPLQEQ LLEIAEKSPN WATKFWLPEM YMRVRMPTPV NSNPGYIFPK VKFETKEDHI 

       130        140        150        160        170        180 
KYTALLTRGL LEYKNLIDTK QVCREKSTGA QKLQMCMEQY DRVLSCYREP GVGEDTQIRK 

       190        200        210        220        230        240 
QKTNDGNEHV LVMCRNQTFL LHSRINGALV SYADVEYQLA QIEEISKINQ NNTANIGASG 

       250        260        270        280        290        300 
VGPRDNAALF WQDMLTVEQN SKSYEWVKSA LFVVCLDMED PIDYGKNDTM SISEKEKEFV 

       310        320        330        340        350        360 
ARGYSTLTGH GSSKFGLNRW YDATIQLVVS SSGVNGLCIE HSTAEGIVII NMAETAIRYA 

       370        380        390        400        410        420 
QKYFKSKMVW NDVRNVHPKS LTWHFSENSR NILKKQAEVF DELANELELE VLIFNEFGKD 

       430        440        450        460        470        480 
SIKNWRVSPD GFIQLIMQLA HYKTHGHLVS TYESASVRRF GAGRVDNIRA NTQEALEWVT 

       490        500        510        520        530        540 
AMASKKESKE RKLELFKKAV LKQVKVTLEN ISGYGVDNHL CALFCLARER EETTGEDIPS 

       550        560        570        580        590        600 
LFLDPLWSEV MRFPLSTSQV TTSLDIPDCY LTYGAVVRDG YGCPYNIQPD RVIFAPTAFR 

       610        620 
SDPRTDLQHF KKSLAGAMRD VKELLSN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans."
Alfonso A., Grundahl K., McManus J.R., Rand J.B.
J. Neurosci. 14:2290-2300(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08969 mRNA. Translation: AAA53659.1.
L08970 Genomic DNA. Translation: AAA53660.1.
FO080977 Genomic DNA. Translation: CCD68242.1.
PIRT37293.
RefSeqNP_001023603.1. NM_001028432.2.
UniGeneCel.16989.

3D structure databases

ProteinModelPortalP32756.
SMRP32756. Positions 16-627.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.ZC416.8b.

Proteomic databases

PaxDbP32756.
PRIDEP32756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZC416.8b; ZC416.8b; WBGene00000481.
GeneID13192683.
KEGGcel:CELE_ZC416.8b.

Organism-specific databases

CTD13192683.
WormBaseZC416.8b; CE17308; WBGene00000481; cha-1.

Phylogenomic databases

eggNOGNOG70127.
GeneTreeENSGT00740000115446.
HOGENOMHOG000233845.
OMAFCLARER.
PhylomeDBP32756.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio895448.
PROP32756.

Entry information

Entry nameCLAT_CAEEL
AccessionPrimary (citable) accession number: P32756
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase