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P32753 (CHLE_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholinesterase

EC=3.1.1.8
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
Pseudocholinesterase
Gene names
Name:BCHE
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length141 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters By similarity.

Catalytic activity

An acylcholine + H2O = choline + a carboxylate.

Subunit structure

Homotetramer; disulfide-linked. Dimer of dimers By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Present in most cells except erythrocytes.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›141›141Cholinesterase
PRO_0000070288

Regions

Region49 – 502Substrate binding By similarity

Sites

Active site1311Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue1311Phosphoserine By similarity
Glycosylation391N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11
Non-terminal residue1411

Sequences

Sequence LengthMass (Da)Tools
P32753 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 5FDFAA11730564D3

FASTA14115,234
        10         20         30         40         50         60 
NTDQSFPGFL GSEMWNPNTD LSEDCLYLNV WIPTPKPKNA TVMIWIYGGS FQTGTSSLHV 

        70         80         90        100        110        120 
YDGKFLARVE RVIVVSMNYR VGALGFLALP GNPEAPGNVG LFDQQLALQW VQKNIAAFGG 

       130        140 
NPKSVTLFGE SAGAASVSLH L 

« Hide

References

[1]"Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates."
Arpagaus M., Chatonnet A., Masson P., Newton M., Vaughan T.A., Bartels C.F., Nogueira C.P., la Du B.N., Lockridge O.
J. Biol. Chem. 266:6966-6974(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62780 Genomic DNA. Translation: AAA31509.1.
PIRB39768.

3D structure databases

ProteinModelPortalP32753.
SMRP32753. Positions 1-141.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106132.

Family and domain databases

InterProIPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00878. CHOLNESTRASE.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHLE_SHEEP
AccessionPrimary (citable) accession number: P32753
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families