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P32751

- CHLE_MACMU

UniProt

P32751 - CHLE_MACMU

Protein

Cholinesterase

Gene

BCHE

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters By similarity.By similarity

    Catalytic activityi

    An acylcholine + H2O = choline + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: UniProtKB
    2. cholinesterase activity Source: UniProtKB

    GO - Biological processi

    1. choline metabolic process Source: RefGenome
    2. synaptic transmission, cholinergic Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Protein family/group databases

    MEROPSiS09.980.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholinesterase (EC:3.1.1.8)
    Alternative name(s):
    Acylcholine acylhydrolase
    Butyrylcholine esterase
    Choline esterase II
    Pseudocholinesterase
    Gene namesi
    Name:BCHE
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: RefGenome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›141›141CholinesterasePRO_0000070286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Modified residuei131 – 1311PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Expressioni

    Tissue specificityi

    Present in most cells except erythrocytes.

    Interactioni

    Subunit structurei

    Homotetramer; disulfide-linked. Dimer of dimers By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000004989.

    Structurei

    3D structure databases

    ProteinModelPortaliP32751.
    SMRiP32751. Positions 1-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 502Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000091866.
    HOVERGENiHBG106132.
    InParanoidiP32751.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P32751-1 [UniParc]FASTAAdd to Basket

    « Hide

    NIDQSFPGFH GSEMWNPNTD LSEDCLYLNV WIPAPKPKNA TVLIWIYGGG    50
    FQTGTSSLHV YDGKFLARVE RVIVVSMNYR VGALGFLALP GNPEAPGNMG 100
    LFDQQLALQW VQKNIAAFGG NPKSVTLFGE SAGAASVSLH L 141
    Length:141
    Mass (Da):15,224
    Last modified:October 1, 1993 - v1
    Checksum:iA3C1135E1650D636
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei141 – 1411

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62777 Genomic DNA. Translation: AAA36836.1.
    PIRiG39768.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62777 Genomic DNA. Translation: AAA36836.1 .
    PIRi G39768.

    3D structure databases

    ProteinModelPortali P32751.
    SMRi P32751. Positions 1-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000004989.

    Chemistry

    BindingDBi P32751.

    Protein family/group databases

    MEROPSi S09.980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000091866.
    HOVERGENi HBG106132.
    InParanoidi P32751.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates."
      Arpagaus M., Chatonnet A., Masson P., Newton M., Vaughan T.A., Bartels C.F., Nogueira C.P., la Du B.N., Lockridge O.
      J. Biol. Chem. 266:6966-6974(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCHLE_MACMU
    AccessioniPrimary (citable) accession number: P32751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3