P32745 (SSR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 3
Short name=SS-3-R
Short name=SS3-R
Short name=SS3R

Alternative name(s):
SSR-28

Gene names

Name:

SSTR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation By similarity.
Tissue specificity	Brain, pituitary and pancreas.
Post-translational modification	Phosphorylated. Phosphorylation increases upon somatostatin binding By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement PubMed 8405411. Source: ProtInc cellular response to estradiol stimulus Inferred from electronic annotation. Source: Compara cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara cerebellum development Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara hormone-mediated apoptotic signaling pathway Traceable author statement PubMed 8961277. Source: ProtInc negative regulation of cell proliferation Traceable author statement PubMed 8961277. Source: ProtInc response to starvation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc nonmotile primary cilium Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	somatostatin receptor activity Traceable author statement PubMed 8405411. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SSTR2	P30874	3	EBI-6266935,EBI-6266898

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Somatostatin receptor type 3		PRO_0000070124
Regions
	Topological domain	1 – 43	43	Extracellular Potential
	Transmembrane	44 – 69	26	Helical; Name=1; Potential
	Topological domain	70 – 79	10	Cytoplasmic Potential
	Transmembrane	80 – 101	22	Helical; Name=2; Potential
	Topological domain	102 – 116	15	Extracellular Potential
	Transmembrane	117 – 138	22	Helical; Name=3; Potential
	Topological domain	139 – 161	23	Cytoplasmic Potential
	Transmembrane	162 – 181	20	Helical; Name=4; Potential
	Topological domain	182 – 205	24	Extracellular Potential
	Transmembrane	206 – 231	26	Helical; Name=5; Potential
	Topological domain	232 – 257	26	Cytoplasmic Potential
	Transmembrane	258 – 279	22	Helical; Name=6; Potential
	Topological domain	280 – 293	14	Extracellular Potential
	Transmembrane	294 – 316	23	Helical; Name=7; Potential
	Topological domain	317 – 418	102	Cytoplasmic Potential
	Compositional bias	346 – 360	15	Glu-rich (acidic)
Amino acid modifications
	Modified residue	348	1	Phosphothreonine By similarity
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Disulfide bond	116 ↔ 191		By similarity
Natural variations
	Natural variant	33	1	A → V. Corresponds to variant rs4988466 [ dbSNP | Ensembl ].		VAR_029219
	Natural variant	37	1	P → L. Corresponds to variant rs34943557 [ dbSNP | Ensembl ].		VAR_049440
	Natural variant	251	1	S → F. Corresponds to variant rs6413537 [ dbSNP | Ensembl ].		VAR_020072
	Natural variant	336	1	R → C. Corresponds to variant rs4988469 [ dbSNP | Ensembl ].		VAR_029220
	Natural variant	411	1	S → T. Corresponds to variant rs229568 [ dbSNP | Ensembl ].		VAR_011853
	Natural variant	414	1	R → H. Corresponds to variant rs4988471 [ dbSNP | Ensembl ].		VAR_029221

Sequences

	Sequence		Length	Mass (Da)
	P32745 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 1227095F801190C4	FASTA	418	45,847
	10 20 30 40 50 60 MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV YLVVCVVGLL 70 80 90 100 110 120 GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL AAQNALSYWP FGSLMCRLVM 130 140 150 160 170 180 AVDGINQFTS IFCLTVMSVD RYLAVVHPTR SARWRTAPVA RTVSAAVWVA SAVVVLPVVV 190 200 210 220 230 240 FSGVPRGMST CHMQWPEPAA AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV 250 260 270 280 290 300 WAPSCQRRRR SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA 310 320 330 340 350 360 LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE EDEEEEDGEE 370 380 390 400 410 SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL PQEASTGEKS STMRISYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase." Yamada Y., Reisine T., Law S.F., Ihara Y., Kubota A., Kagimoto S., Seino M., Seino Y., Bell G.I., Seino S. Mol. Endocrinol. 6:2136-2142(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides." Corness J.D., Demchyshyn L.L., Seeman P., van Tol H.H.M., Srikant C.B., Kent G., Patel Y.C., Niznik H.B. FEBS Lett. 321:279-284(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The human somatostatin receptor subtype 3 contains an upstream exon in the 5'-untranslated region: functional promoter studies." Rasch A.C., Boehnke C., Petersenn S. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96738 Genomic DNA. Translation: AAA60592.1. AY277678 Genomic DNA. Translation: AAP32288.1. AY322541 Genomic DNA. Translation: AAP84354.1. CR456585 mRNA. Translation: CAG30471.1. AK291165 mRNA. Translation: BAF83854.1. Z82188 Genomic DNA. Translation: CAB45263.1. BC096829 mRNA. Translation: AAH96829.1.
IPI	IPI00030283.
PIR	A46226.
RefSeq	NP_001042.1. NM_001051.2.
UniGene	Hs.225995.
3D structure databases
ProteinModelPortal	P32745.
ModBase	Search...
Protein-protein interaction databases
IntAct	P32745. 1 interaction.
MINT	MINT-6800539.
STRING	9606.ENSP00000330138.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P32745.
Polymorphism databases
DMDM	417815.
Proteomic databases
PaxDb	P32745.
PRIDE	P32745.
Protocols and materials databases
DNASU	6753.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328544; ENSP00000330138; ENSG00000183473. ENST00000402501; ENSP00000384904; ENSG00000183473.
GeneID	6753.
KEGG	hsa:6753.
UCSC	uc003ara.3. human.
Organism-specific databases
CTD	6753.
GeneCards	GC22M037600.
HGNC	HGNC:11332. SSTR3.
HPA	CAB022647.
MIM	182453. gene.
neXtProt	NX_P32745.
PharmGKB	PA36156.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274661.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	P32745.
KO	K04219.
OMA	NASSAWP.
OrthoDB	EOG4XPQGG.
PhylomeDB	P32745.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P32745.
Bgee	P32745.
CleanEx	HS_SSTR3.
Genevestigator	P32745.
GermOnline	ENSG00000183473. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001856. Somatstn_rcpt_3. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00589. SOMATOSTTN3R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P32745.
ChEMBL	CHEMBL2028.
GenomeRNAi	6753.
NextBio	26344.
SOURCE	Search...

Entry information

Entry name

SSR3_HUMAN

Accession

Primary (citable) accession number: P32745
Secondary accession number(s): A8K550, Q53ZR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 128 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.