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Protein

Somatostatin receptor type 3

Gene

SSTR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:SSTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000278195.1
HGNCiHGNC:11332 SSTR3
MIMi182453 gene
neXtProtiNX_P32745

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 69Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini70 – 79CytoplasmicSequence analysis10
Transmembranei80 – 101Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini102 – 116ExtracellularSequence analysisAdd BLAST15
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 161CytoplasmicSequence analysisAdd BLAST23
Transmembranei162 – 181Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini182 – 205ExtracellularSequence analysisAdd BLAST24
Transmembranei206 – 231Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini232 – 257CytoplasmicSequence analysisAdd BLAST26
Transmembranei258 – 279Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini280 – 293ExtracellularSequence analysisAdd BLAST14
Transmembranei294 – 316Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini317 – 418CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6753
OpenTargetsiENSG00000278195
PharmGKBiPA36156

Chemistry databases

ChEMBLiCHEMBL2028
DrugBankiDB06663 Pasireotide
GuidetoPHARMACOLOGYi357

Polymorphism and mutation databases

BioMutaiSSTR3
DMDMi417815

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701241 – 418Somatostatin receptor type 3Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 191PROSITE-ProRule annotation
Modified residuei332PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei348PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32745
PeptideAtlasiP32745
PRIDEiP32745

PTM databases

iPTMnetiP32745
PhosphoSitePlusiP32745

Expressioni

Tissue specificityi

Brain, pituitary and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000278195
CleanExiHS_SSTR3
GenevisibleiP32745 HS

Organism-specific databases

HPAiCAB022647

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112631, 13 interactors
IntActiP32745, 9 interactors
MINTiP32745
STRINGi9606.ENSP00000330138

Chemistry databases

BindingDBiP32745

Structurei

3D structure databases

ProteinModelPortaliP32745
SMRiP32745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 360Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP32745
KOiK04219
OMAiPYANSCA
OrthoDBiEOG091G0HEN
PhylomeDBiP32745
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001856 Somatstn_rcpt_3
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00589 SOMATOSTTN3R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV
60 70 80 90 100
YLVVCVVGLL GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL
110 120 130 140 150
AAQNALSYWP FGSLMCRLVM AVDGINQFTS IFCLTVMSVD RYLAVVHPTR
160 170 180 190 200
SARWRTAPVA RTVSAAVWVA SAVVVLPVVV FSGVPRGMST CHMQWPEPAA
210 220 230 240 250
AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV WAPSCQRRRR
260 270 280 290 300
SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA
310 320 330 340 350
LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE
360 370 380 390 400
EDEEEEDGEE SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL
410
PQEASTGEKS STMRISYL
Length:418
Mass (Da):45,847
Last modified:October 1, 1993 - v1
Checksum:i1227095F801190C4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02921933A → V. Corresponds to variant dbSNP:rs4988466Ensembl.1
Natural variantiVAR_04944037P → L. Corresponds to variant dbSNP:rs34943557Ensembl.1
Natural variantiVAR_020072251S → F. Corresponds to variant dbSNP:rs6413537Ensembl.1
Natural variantiVAR_029220336R → C. Corresponds to variant dbSNP:rs4988469Ensembl.1
Natural variantiVAR_011853411S → T. Corresponds to variant dbSNP:rs229568Ensembl.1
Natural variantiVAR_029221414R → H. Corresponds to variant dbSNP:rs4988471Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96738 Genomic DNA Translation: AAA60592.1
AY277678 Genomic DNA Translation: AAP32288.1
AY322541 Genomic DNA Translation: AAP84354.1
CR456585 mRNA Translation: CAG30471.1
AK291165 mRNA Translation: BAF83854.1
Z82188 Genomic DNA No translation available.
BC096829 mRNA Translation: AAH96829.1
CCDSiCCDS13944.1
PIRiA46226
RefSeqiNP_001042.1, NM_001051.4
NP_001265616.1, NM_001278687.2
XP_005261778.1, XM_005261721.4
XP_006724374.1, XM_006724311.2
XP_011528651.1, XM_011530349.2
XP_016884412.1, XM_017028923.1
XP_016884413.1, XM_017028924.1
UniGeneiHs.225995
Hs.255208

Genome annotation databases

EnsembliENST00000610913; ENSP00000480971; ENSG00000278195
ENST00000617123; ENSP00000481325; ENSG00000278195
GeneIDi6753
KEGGihsa:6753
UCSCiuc021wos.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSR3_HUMAN
AccessioniPrimary (citable) accession number: P32745
Secondary accession number(s): A8K550, Q53ZR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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