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Protein

Somatostatin receptor type 3

Gene

SSTR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31488-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-5620922. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:SSTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11332. SSTR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 69Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini70 – 79CytoplasmicSequence analysis10
Transmembranei80 – 101Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini102 – 116ExtracellularSequence analysisAdd BLAST15
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 161CytoplasmicSequence analysisAdd BLAST23
Transmembranei162 – 181Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini182 – 205ExtracellularSequence analysisAdd BLAST24
Transmembranei206 – 231Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini232 – 257CytoplasmicSequence analysisAdd BLAST26
Transmembranei258 – 279Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini280 – 293ExtracellularSequence analysisAdd BLAST14
Transmembranei294 – 316Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini317 – 418CytoplasmicSequence analysisAdd BLAST102

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6753.
OpenTargetsiENSG00000278195.
PharmGKBiPA36156.

Chemistry databases

ChEMBLiCHEMBL2028.
DrugBankiDB06663. Pasireotide.
GuidetoPHARMACOLOGYi357.

Polymorphism and mutation databases

BioMutaiSSTR3.
DMDMi417815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701241 – 418Somatostatin receptor type 3Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 191PROSITE-ProRule annotation
Modified residuei348PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32745.
PRIDEiP32745.

PTM databases

iPTMnetiP32745.
PhosphoSitePlusiP32745.

Expressioni

Tissue specificityi

Brain, pituitary and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000183473.
CleanExiHS_SSTR3.
GenevisibleiP32745. HS.

Organism-specific databases

HPAiCAB022647.

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759705EBI-6266935,EBI-821405
MpdzO551642EBI-6266935,EBI-7401093From a different organism.
SSTR2P308743EBI-6266935,EBI-6266898

Protein-protein interaction databases

BioGridi112631. 13 interactors.
IntActiP32745. 9 interactors.
MINTiMINT-6800539.
STRINGi9606.ENSP00000330138.

Chemistry databases

BindingDBiP32745.

Structurei

3D structure databases

ProteinModelPortaliP32745.
SMRiP32745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 360Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP32745.
KOiK04219.
OMAiRVWAPSC.
OrthoDBiEOG091G0HEN.
PhylomeDBiP32745.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV
60 70 80 90 100
YLVVCVVGLL GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL
110 120 130 140 150
AAQNALSYWP FGSLMCRLVM AVDGINQFTS IFCLTVMSVD RYLAVVHPTR
160 170 180 190 200
SARWRTAPVA RTVSAAVWVA SAVVVLPVVV FSGVPRGMST CHMQWPEPAA
210 220 230 240 250
AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV WAPSCQRRRR
260 270 280 290 300
SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA
310 320 330 340 350
LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE
360 370 380 390 400
EDEEEEDGEE SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL
410
PQEASTGEKS STMRISYL
Length:418
Mass (Da):45,847
Last modified:October 1, 1993 - v1
Checksum:i1227095F801190C4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02921933A → V.Corresponds to variant rs4988466dbSNPEnsembl.1
Natural variantiVAR_04944037P → L.Corresponds to variant rs34943557dbSNPEnsembl.1
Natural variantiVAR_020072251S → F.Corresponds to variant rs6413537dbSNPEnsembl.1
Natural variantiVAR_029220336R → C.Corresponds to variant rs4988469dbSNPEnsembl.1
Natural variantiVAR_011853411S → T.Corresponds to variant rs229568dbSNPEnsembl.1
Natural variantiVAR_029221414R → H.Corresponds to variant rs4988471dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96738 Genomic DNA. Translation: AAA60592.1.
AY277678 Genomic DNA. Translation: AAP32288.1.
AY322541 Genomic DNA. Translation: AAP84354.1.
CR456585 mRNA. Translation: CAG30471.1.
AK291165 mRNA. Translation: BAF83854.1.
Z82188 Genomic DNA. Translation: CAB45263.1.
BC096829 mRNA. Translation: AAH96829.1.
CCDSiCCDS13944.1.
PIRiA46226.
RefSeqiNP_001042.1. NM_001051.4.
NP_001265616.1. NM_001278687.2.
XP_005261778.1. XM_005261721.4.
XP_006724374.1. XM_006724311.2.
XP_011528651.1. XM_011530349.2.
XP_016884412.1. XM_017028923.1.
XP_016884413.1. XM_017028924.1.
UniGeneiHs.225995.
Hs.255208.

Genome annotation databases

EnsembliENST00000610913; ENSP00000480971; ENSG00000278195.
ENST00000617123; ENSP00000481325; ENSG00000278195.
GeneIDi6753.
KEGGihsa:6753.
UCSCiuc021wos.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96738 Genomic DNA. Translation: AAA60592.1.
AY277678 Genomic DNA. Translation: AAP32288.1.
AY322541 Genomic DNA. Translation: AAP84354.1.
CR456585 mRNA. Translation: CAG30471.1.
AK291165 mRNA. Translation: BAF83854.1.
Z82188 Genomic DNA. Translation: CAB45263.1.
BC096829 mRNA. Translation: AAH96829.1.
CCDSiCCDS13944.1.
PIRiA46226.
RefSeqiNP_001042.1. NM_001051.4.
NP_001265616.1. NM_001278687.2.
XP_005261778.1. XM_005261721.4.
XP_006724374.1. XM_006724311.2.
XP_011528651.1. XM_011530349.2.
XP_016884412.1. XM_017028923.1.
XP_016884413.1. XM_017028924.1.
UniGeneiHs.225995.
Hs.255208.

3D structure databases

ProteinModelPortaliP32745.
SMRiP32745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112631. 13 interactors.
IntActiP32745. 9 interactors.
MINTiMINT-6800539.
STRINGi9606.ENSP00000330138.

Chemistry databases

BindingDBiP32745.
ChEMBLiCHEMBL2028.
DrugBankiDB06663. Pasireotide.
GuidetoPHARMACOLOGYi357.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32745.
PhosphoSitePlusiP32745.

Polymorphism and mutation databases

BioMutaiSSTR3.
DMDMi417815.

Proteomic databases

PaxDbiP32745.
PRIDEiP32745.

Protocols and materials databases

DNASUi6753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610913; ENSP00000480971; ENSG00000278195.
ENST00000617123; ENSP00000481325; ENSG00000278195.
GeneIDi6753.
KEGGihsa:6753.
UCSCiuc021wos.3. human.

Organism-specific databases

CTDi6753.
DisGeNETi6753.
GeneCardsiSSTR3.
HGNCiHGNC:11332. SSTR3.
HPAiCAB022647.
MIMi182453. gene.
neXtProtiNX_P32745.
OpenTargetsiENSG00000278195.
PharmGKBiPA36156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP32745.
KOiK04219.
OMAiRVWAPSC.
OrthoDBiEOG091G0HEN.
PhylomeDBiP32745.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:G66-31488-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-5620922. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

GeneWikiiSomatostatin_receptor_3.
GenomeRNAii6753.
PROiP32745.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183473.
CleanExiHS_SSTR3.
GenevisibleiP32745. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR3_HUMAN
AccessioniPrimary (citable) accession number: P32745
Secondary accession number(s): A8K550, Q53ZR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.