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Protein

Somatostatin receptor type 3

Gene

SSTR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

  • somatostatin receptor activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular response to estradiol stimulus Source: Ensembl
  • cellular response to glucocorticoid stimulus Source: Ensembl
  • cerebellum development Source: Ensembl
  • forebrain development Source: Ensembl
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • hormone-mediated apoptotic signaling pathway Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
  • organelle organization Source: Reactome
  • response to starvation Source: Ensembl
  • somatostatin signaling pathway Source: GOC
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
REACT_267948. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:SSTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11332. SSTR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6926Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini70 – 7910CytoplasmicSequence Analysis
Transmembranei80 – 10122Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini102 – 11615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 16123CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18120Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 20524ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 23126Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini232 – 25726CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei258 – 27922Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 29314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei294 – 31623Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini317 – 418102CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • ciliary membrane Source: Reactome
  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • nonmotile primary cilium Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36156.

Chemistry

DrugBankiDB06663. Pasireotide.

Polymorphism and mutation databases

BioMutaiSSTR3.
DMDMi417815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Somatostatin receptor type 3PRO_0000070124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 191PROSITE-ProRule annotation
Modified residuei348 – 3481PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32745.
PRIDEiP32745.

PTM databases

PhosphoSiteiP32745.

Expressioni

Tissue specificityi

Brain, pituitary and pancreas.1 Publication

Gene expression databases

BgeeiP32745.
CleanExiHS_SSTR3.
GenevisibleiP32745. HS.

Organism-specific databases

HPAiCAB022647.

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759705EBI-6266935,EBI-821405
MpdzO551642EBI-6266935,EBI-7401093From a different organism.
SSTR2P308743EBI-6266935,EBI-6266898

Protein-protein interaction databases

BioGridi112631. 13 interactions.
IntActiP32745. 9 interactions.
MINTiMINT-6800539.
STRINGi9606.ENSP00000330138.

Structurei

3D structure databases

ProteinModelPortaliP32745.
SMRiP32745. Positions 37-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi346 – 36015Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP32745.
KOiK04219.
OMAiNASSAWP.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP32745.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV
60 70 80 90 100
YLVVCVVGLL GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL
110 120 130 140 150
AAQNALSYWP FGSLMCRLVM AVDGINQFTS IFCLTVMSVD RYLAVVHPTR
160 170 180 190 200
SARWRTAPVA RTVSAAVWVA SAVVVLPVVV FSGVPRGMST CHMQWPEPAA
210 220 230 240 250
AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV WAPSCQRRRR
260 270 280 290 300
SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA
310 320 330 340 350
LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE
360 370 380 390 400
EDEEEEDGEE SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL
410
PQEASTGEKS STMRISYL
Length:418
Mass (Da):45,847
Last modified:October 1, 1993 - v1
Checksum:i1227095F801190C4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331A → V.
Corresponds to variant rs4988466 [ dbSNP | Ensembl ].
VAR_029219
Natural varianti37 – 371P → L.
Corresponds to variant rs34943557 [ dbSNP | Ensembl ].
VAR_049440
Natural varianti251 – 2511S → F.
Corresponds to variant rs6413537 [ dbSNP | Ensembl ].
VAR_020072
Natural varianti336 – 3361R → C.
Corresponds to variant rs4988469 [ dbSNP | Ensembl ].
VAR_029220
Natural varianti411 – 4111S → T.
Corresponds to variant rs229568 [ dbSNP | Ensembl ].
VAR_011853
Natural varianti414 – 4141R → H.
Corresponds to variant rs4988471 [ dbSNP | Ensembl ].
VAR_029221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96738 Genomic DNA. Translation: AAA60592.1.
AY277678 Genomic DNA. Translation: AAP32288.1.
AY322541 Genomic DNA. Translation: AAP84354.1.
CR456585 mRNA. Translation: CAG30471.1.
AK291165 mRNA. Translation: BAF83854.1.
Z82188 Genomic DNA. Translation: CAB45263.1.
BC096829 mRNA. Translation: AAH96829.1.
CCDSiCCDS13944.1.
PIRiA46226.
RefSeqiNP_001042.1. NM_001051.4.
NP_001265616.1. NM_001278687.2.
XP_005261778.1. XM_005261721.3.
XP_006724374.1. XM_006724311.2.
UniGeneiHs.225995.
Hs.255208.

Genome annotation databases

EnsembliENST00000610913; ENSP00000480971; ENSG00000278195.
ENST00000617123; ENSP00000481325; ENSG00000278195.
GeneIDi6753.
KEGGihsa:6753.
UCSCiuc003ara.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96738 Genomic DNA. Translation: AAA60592.1.
AY277678 Genomic DNA. Translation: AAP32288.1.
AY322541 Genomic DNA. Translation: AAP84354.1.
CR456585 mRNA. Translation: CAG30471.1.
AK291165 mRNA. Translation: BAF83854.1.
Z82188 Genomic DNA. Translation: CAB45263.1.
BC096829 mRNA. Translation: AAH96829.1.
CCDSiCCDS13944.1.
PIRiA46226.
RefSeqiNP_001042.1. NM_001051.4.
NP_001265616.1. NM_001278687.2.
XP_005261778.1. XM_005261721.3.
XP_006724374.1. XM_006724311.2.
UniGeneiHs.225995.
Hs.255208.

3D structure databases

ProteinModelPortaliP32745.
SMRiP32745. Positions 37-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112631. 13 interactions.
IntActiP32745. 9 interactions.
MINTiMINT-6800539.
STRINGi9606.ENSP00000330138.

Chemistry

BindingDBiP32745.
ChEMBLiCHEMBL2028.
DrugBankiDB06663. Pasireotide.
GuidetoPHARMACOLOGYi357.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP32745.

Polymorphism and mutation databases

BioMutaiSSTR3.
DMDMi417815.

Proteomic databases

PaxDbiP32745.
PRIDEiP32745.

Protocols and materials databases

DNASUi6753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610913; ENSP00000480971; ENSG00000278195.
ENST00000617123; ENSP00000481325; ENSG00000278195.
GeneIDi6753.
KEGGihsa:6753.
UCSCiuc003ara.3. human.

Organism-specific databases

CTDi6753.
GeneCardsiGC22M037600.
HGNCiHGNC:11332. SSTR3.
HPAiCAB022647.
MIMi182453. gene.
neXtProtiNX_P32745.
PharmGKBiPA36156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP32745.
KOiK04219.
OMAiNASSAWP.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP32745.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
REACT_267948. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

GeneWikiiSomatostatin_receptor_3.
GenomeRNAii6753.
NextBioi26344.
PROiP32745.
SOURCEiSearch...

Gene expression databases

BgeeiP32745.
CleanExiHS_SSTR3.
GenevisibleiP32745. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase."
    Yamada Y., Reisine T., Law S.F., Ihara Y., Kubota A., Kagimoto S., Seino M., Seino Y., Bell G.I., Seino S.
    Mol. Endocrinol. 6:2136-2142(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
  2. "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides."
    Corness J.D., Demchyshyn L.L., Seeman P., van Tol H.H.M., Srikant C.B., Kent G., Patel Y.C., Niznik H.B.
    FEBS Lett. 321:279-284(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The human somatostatin receptor subtype 3 contains an upstream exon in the 5'-untranslated region: functional promoter studies."
    Rasch A.C., Boehnke C., Petersenn S.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSSR3_HUMAN
AccessioniPrimary (citable) accession number: P32745
Secondary accession number(s): A8K550, Q53ZR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 24, 2015
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.