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Protein

Opioid-binding protein/cell adhesion molecule

Gene

Opcml

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Gene namesi
Name:Opcml
Synonyms:Obcam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620635. Opcml.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000001512228 – 322Opioid-binding protein/cell adhesion moleculeAdd BLAST295
PropeptideiPRO_0000015123323 – 345Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Lipidationi322GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP32736.
PRIDEiP32736.

PTM databases

iPTMnetiP32736.
PhosphoSitePlusiP32736.
UniCarbKBiP32736.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044106.

Structurei

3D structure databases

ProteinModelPortaliP32736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 219Ig-like C2-type 2Add BLAST84
Domaini223 – 310Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiP32736.
KOiK06773.
PhylomeDBiP32736.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P32736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEI
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKED TRLATGLDGV RIENKGRIST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTFFAH FFIKF
Length:345
Mass (Da):38,068
Last modified:February 1, 1996 - v2
Checksum:iA3181B0753F9658E
GO
Isoform 2 (identifier: P32736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWIVFSATTALLFIP

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,341
Checksum:i30CAF1ADB5C109E5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0026121 – 27MGVCG…FLVPT → MYHPAYWIVFSATTALLFIP in isoform 2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88710 mRNA. Translation: AAA40859.1.
M88711 mRNA. Translation: AAA40860.1.
M88709 mRNA. Translation: AAA40858.1.
PIRiJC1238.
JC1239.
RefSeqiNP_446300.1. NM_053848.1. [P32736-1]
UniGeneiRn.11366.

Genome annotation databases

GeneIDi116597.
KEGGirno:116597.
UCSCiRGD:620635. rat. [P32736-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88710 mRNA. Translation: AAA40859.1.
M88711 mRNA. Translation: AAA40860.1.
M88709 mRNA. Translation: AAA40858.1.
PIRiJC1238.
JC1239.
RefSeqiNP_446300.1. NM_053848.1. [P32736-1]
UniGeneiRn.11366.

3D structure databases

ProteinModelPortaliP32736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044106.

PTM databases

iPTMnetiP32736.
PhosphoSitePlusiP32736.
UniCarbKBiP32736.

Proteomic databases

PaxDbiP32736.
PRIDEiP32736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116597.
KEGGirno:116597.
UCSCiRGD:620635. rat. [P32736-1]

Organism-specific databases

CTDi4978.
RGDi620635. Opcml.

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiP32736.
KOiK06773.
PhylomeDBiP32736.

Miscellaneous databases

PROiP32736.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPCM_RAT
AccessioniPrimary (citable) accession number: P32736
Secondary accession number(s): P32735, Q01653, Q01654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.