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Protein

Opioid-binding protein/cell adhesion molecule

Gene

Opcml

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Gene namesi
Name:Opcml
Synonyms:Obcam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620635. Opcml.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 322295Opioid-binding protein/cell adhesion moleculePRO_0000015122Add
BLAST
Propeptidei323 – 34523Removed in mature formSequence analysisPRO_0000015123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence analysis
Lipidationi322 – 3221GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP32736.
PRIDEiP32736.

PTM databases

PhosphoSiteiP32736.
UniCarbKBiP32736.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044106.

Structurei

3D structure databases

ProteinModelPortaliP32736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12688Ig-like C2-type 1Add
BLAST
Domaini136 – 21984Ig-like C2-type 2Add
BLAST
Domaini223 – 31088Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiP32736.
KOiK06773.
PhylomeDBiP32736.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P32736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEI
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKED TRLATGLDGV RIENKGRIST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTFFAH FFIKF
Length:345
Mass (Da):38,068
Last modified:February 1, 1996 - v2
Checksum:iA3181B0753F9658E
GO
Isoform 2 (identifier: P32736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWIVFSATTALLFIP

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,341
Checksum:i30CAF1ADB5C109E5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MGVCG…FLVPT → MYHPAYWIVFSATTALLFIP in isoform 2. CuratedVSP_002612Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88710 mRNA. Translation: AAA40859.1.
M88711 mRNA. Translation: AAA40860.1.
M88709 mRNA. Translation: AAA40858.1.
PIRiJC1238.
JC1239.
RefSeqiNP_446300.1. NM_053848.1. [P32736-1]
UniGeneiRn.11366.

Genome annotation databases

GeneIDi116597.
KEGGirno:116597.
UCSCiRGD:620635. rat. [P32736-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88710 mRNA. Translation: AAA40859.1.
M88711 mRNA. Translation: AAA40860.1.
M88709 mRNA. Translation: AAA40858.1.
PIRiJC1238.
JC1239.
RefSeqiNP_446300.1. NM_053848.1. [P32736-1]
UniGeneiRn.11366.

3D structure databases

ProteinModelPortaliP32736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044106.

PTM databases

PhosphoSiteiP32736.
UniCarbKBiP32736.

Proteomic databases

PaxDbiP32736.
PRIDEiP32736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116597.
KEGGirno:116597.
UCSCiRGD:620635. rat. [P32736-1]

Organism-specific databases

CTDi4978.
RGDi620635. Opcml.

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiP32736.
KOiK06773.
PhylomeDBiP32736.

Miscellaneous databases

NextBioi619295.
PROiP32736.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library."
    Lippman D.A., Lee N.M., Loh H.H.
    Gene 117:249-254(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 33-40; 49-62; 72-87; 171-214; 218-228; 240-258; 263-271 AND 302-344, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules."
    Struyk A.F., Canoll P.D., Wolfgang M.J., Rosen C.L., D'Eustachio P., Salzer J.L.
    J. Neurosci. 15:2141-2156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 195-214, GPI-ANCHOR.

Entry informationi

Entry nameiOPCM_RAT
AccessioniPrimary (citable) accession number: P32736
Secondary accession number(s): P32735, Q01653, Q01654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.