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Protein

Opioid-binding protein/cell adhesion molecule

Gene

Opcml

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Gene namesi
Name:Opcml
Synonyms:Obcam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620635 Opcml

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000001512228 – 322Opioid-binding protein/cell adhesion moleculeAdd BLAST295
PropeptideiPRO_0000015123323 – 345Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi322GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP32736
PRIDEiP32736

PTM databases

iPTMnetiP32736
PhosphoSitePlusiP32736
UniCarbKBiP32736

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044106

Structurei

3D structure databases

ProteinModelPortaliP32736
SMRiP32736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 219Ig-like C2-type 2Add BLAST84
Domaini223 – 310Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
ENOG410XPX0 LUCA
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiP32736
KOiK06773
PhylomeDBiP32736

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P32736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEI
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKED TRLATGLDGV RIENKGRIST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTFFAH FFIKF
Length:345
Mass (Da):38,068
Last modified:February 1, 1996 - v2
Checksum:iA3181B0753F9658E
GO
Isoform 2 (identifier: P32736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWIVFSATTALLFIP

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,341
Checksum:i30CAF1ADB5C109E5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0026121 – 27MGVCG…FLVPT → MYHPAYWIVFSATTALLFIP in isoform 2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88710 mRNA Translation: AAA40859.1
M88711 mRNA Translation: AAA40860.1
M88709 mRNA Translation: AAA40858.1
PIRiJC1238
JC1239
RefSeqiNP_446300.1, NM_053848.1 [P32736-1]
UniGeneiRn.11366

Genome annotation databases

GeneIDi116597
KEGGirno:116597
UCSCiRGD:620635 rat [P32736-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOPCM_RAT
AccessioniPrimary (citable) accession number: P32736
Secondary accession number(s): P32735, Q01653, Q01654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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