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Protein

D-allose import ATP-binding protein AlsA

Gene

alsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system.1 Publication

Catalytic activityi

ATP + H2O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sugar transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YJCW-MONOMER.
ECOL316407:JW4048-MONOMER.
MetaCyc:YJCW-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.6. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
D-allose import ATP-binding protein AlsA (EC:3.6.3.17)
Gene namesi
Name:alsA
Synonyms:yjcW
Ordered Locus Names:b4087, JW4048
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11959. alsA.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919261 – 510D-allose import ATP-binding protein AlsAAdd BLAST510

Proteomic databases

PaxDbiP32721.
PRIDEiP32721.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (AlsA), two transmembrane proteins (AlsC) and a solute-binding protein (AlsB).Curated

Protein-protein interaction databases

BioGridi4260960. 6 interactors.
DIPiDIP-9093N.
IntActiP32721. 5 interactors.
STRINGi511145.b4087.

Structurei

3D structure databases

ProteinModelPortaliP32721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 245ABC transporter 1PROSITE-ProRule annotationAdd BLAST240
Domaini260 – 509ABC transporter 2PROSITE-ProRule annotationAdd BLAST250

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2J. Bacteria.
COG1129. LUCA.
InParanoidiP32721.
KOiK10551.
OMAiHSINQNI.
PhylomeDBiP32721.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPYISMAG IGKSFGPVHA LKSVNLTVYP GEIHALLGEN GAGKSTLMKV
60 70 80 90 100
LSGIHEPTKG TITINNISYN KLDHKLAAQL GIGIIYQELS VIDELTVLEN
110 120 130 140 150
LYIGRHLTKK ICGVNIIDWR EMRVRAAMML LRVGLKVDLD EKVANLSISH
160 170 180 190 200
KQMLEIAKTL MLDAKVIIMD EPTSSLTNKE VDYLFLIMNQ LRKEGTAIVY
210 220 230 240 250
ISHKLAEIRR ICDRYTVMKD GSSVCSGIVS DVSNDDIVRL MVGRELQNRF
260 270 280 290 300
NAMKENVSNL AHETVFEVRN VTSRDRKKVR DISFSVCRGE ILGFAGLVGS
310 320 330 340 350
GRTELMNCLF GVDKRAGGEI RLNGKDISPR SPLDAVKKGM AYITESRRDN
360 370 380 390 400
GFFPNFSIAQ NMAISRSLKD GGYKGAMGLF HEVDEQRTAE NQRELLALKC
410 420 430 440 450
HSVNQNITEL SGGNQQKVLI SKWLCCCPEV IIFDEPTRGI DVGAKAEIYK
460 470 480 490 500
VMRQLADDGK VILMVSSELP EIITVCDRIA VFCEGRLTQI LTNRDDMSEE
510
EIMAWALPQE
Length:510
Mass (Da):56,745
Last modified:February 1, 1995 - v2
Checksum:i733FA8ABD3618EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA96986.1.
U00096 Genomic DNA. Translation: AAC77048.1.
AP009048 Genomic DNA. Translation: BAE78090.1.
U00006 Genomic DNA. Translation: AAC43181.1.
PIRiS56315.
RefSeqiNP_418511.1. NC_000913.3.
WP_000235257.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77048; AAC77048; b4087.
BAE78090; BAE78090; BAE78090.
GeneIDi948593.
KEGGiecj:JW4048.
eco:b4087.
PATRICi32123729. VBIEscCol129921_4213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA96986.1.
U00096 Genomic DNA. Translation: AAC77048.1.
AP009048 Genomic DNA. Translation: BAE78090.1.
U00006 Genomic DNA. Translation: AAC43181.1.
PIRiS56315.
RefSeqiNP_418511.1. NC_000913.3.
WP_000235257.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260960. 6 interactors.
DIPiDIP-9093N.
IntActiP32721. 5 interactors.
STRINGi511145.b4087.

Protein family/group databases

TCDBi3.A.1.2.6. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP32721.
PRIDEiP32721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77048; AAC77048; b4087.
BAE78090; BAE78090; BAE78090.
GeneIDi948593.
KEGGiecj:JW4048.
eco:b4087.
PATRICi32123729. VBIEscCol129921_4213.

Organism-specific databases

EchoBASEiEB1902.
EcoGeneiEG11959. alsA.

Phylogenomic databases

eggNOGiENOG4105C2J. Bacteria.
COG1129. LUCA.
InParanoidiP32721.
KOiK10551.
OMAiHSINQNI.
PhylomeDBiP32721.

Enzyme and pathway databases

BioCyciEcoCyc:YJCW-MONOMER.
ECOL316407:JW4048-MONOMER.
MetaCyc:YJCW-MONOMER.

Miscellaneous databases

PROiP32721.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALSA_ECOLI
AccessioniPrimary (citable) accession number: P32721
Secondary accession number(s): Q2M6L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.