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Protein

Multidrug resistance protein MdtN

Gene

mdtN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.

GO - Molecular functioni

  • sulfathiazole transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • sulfathiazole transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11954-MONOMER.
ECOL316407:JW4043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtN
Gene namesi
Name:mdtN
Synonyms:yjcR
Ordered Locus Names:b4082, JW4043
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11954. mdtN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 343PeriplasmicSequence analysisAdd BLAST310

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018831 – 343Multidrug resistance protein MdtNAdd BLAST343

Proteomic databases

PaxDbiP32716.
PRIDEiP32716.

Expressioni

Inductioni

Induced by LeuO, part of the mdtNO operon.1 Publication

Interactioni

Subunit structurei

Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP.

Protein-protein interaction databases

BioGridi4262953. 208 interactors.
IntActiP32716. 3 interactors.
STRINGi511145.b4082.

Structurei

3D structure databases

ProteinModelPortaliP32716.
SMRiP32716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105J12. Bacteria.
COG1566. LUCA.
HOGENOMiHOG000112073.
InParanoidiP32716.
KOiK15549.
OMAiSTMRPIF.
PhylomeDBiP32716.

Family and domain databases

InterProiIPR005694. Emr.
IPR030196. MdtN.
[Graphical view]
PANTHERiPTHR30367:SF1. PTHR30367:SF1. 1 hit.
TIGRFAMsiTIGR00998. 8a0101. 1 hit.

Sequencei

Sequence statusi: Complete.

P32716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTPKKAPR SKFPALLVVA LALVALVFVI WRVDSAPSTN DAYASADTID
60 70 80 90 100
VVPEVSGRIV ELAVTDNQAV KQGDLLFRID PRPYEANLAK AEASLAALDK
110 120 130 140 150
QIMLTQRSVD AQQFGADSVN ATVEKARAAA KQATDTLRRT EPLLKEGFVS
160 170 180 190 200
AEDVDRARTA QRAAEADLNA VLLQAQSAAS AVSGVDALVA QRAAVEADIA
210 220 230 240 250
LTKLHLEMAT VRAPFDGRVI SLKTSVGQFA SAMRPIFTLI DTRHWYVIAN
260 270 280 290 300
FRETDLKNIR SGTPATIRLM SDSGKTFEGK VDSIGYGVLP DDGGLVLGGL
310 320 330 340
PKVSRSINWV RVAQRFPVKI MVDKPDPEMF RIGASAVANL EPQ
Length:343
Mass (Da):36,908
Last modified:October 1, 1993 - v1
Checksum:iC599B8707C475FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43176.1.
U00096 Genomic DNA. Translation: AAD13465.1.
AP009048 Genomic DNA. Translation: BAE78084.1.
PIRiA65217.
RefSeqiNP_418506.1. NC_000913.3.
WP_000446378.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAD13465; AAD13465; b4082.
BAE78084; BAE78084; BAE78084.
GeneIDi948598.
KEGGiecj:JW4043.
eco:b4082.
PATRICi32123717. VBIEscCol129921_4207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43176.1.
U00096 Genomic DNA. Translation: AAD13465.1.
AP009048 Genomic DNA. Translation: BAE78084.1.
PIRiA65217.
RefSeqiNP_418506.1. NC_000913.3.
WP_000446378.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32716.
SMRiP32716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262953. 208 interactors.
IntActiP32716. 3 interactors.
STRINGi511145.b4082.

Proteomic databases

PaxDbiP32716.
PRIDEiP32716.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13465; AAD13465; b4082.
BAE78084; BAE78084; BAE78084.
GeneIDi948598.
KEGGiecj:JW4043.
eco:b4082.
PATRICi32123717. VBIEscCol129921_4207.

Organism-specific databases

EchoBASEiEB1897.
EcoGeneiEG11954. mdtN.

Phylogenomic databases

eggNOGiENOG4105J12. Bacteria.
COG1566. LUCA.
HOGENOMiHOG000112073.
InParanoidiP32716.
KOiK15549.
OMAiSTMRPIF.
PhylomeDBiP32716.

Enzyme and pathway databases

BioCyciEcoCyc:EG11954-MONOMER.
ECOL316407:JW4043-MONOMER.

Miscellaneous databases

PROiP32716.

Family and domain databases

InterProiIPR005694. Emr.
IPR030196. MdtN.
[Graphical view]
PANTHERiPTHR30367:SF1. PTHR30367:SF1. 1 hit.
TIGRFAMsiTIGR00998. 8a0101. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDTN_ECOLI
AccessioniPrimary (citable) accession number: P32716
Secondary accession number(s): Q2M6M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.