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Protein

Multidrug resistance protein MdtN

Gene

mdtN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.

GO - Molecular functioni

  • sulfathiazole transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • sulfathiazole transport Source: EcoCyc

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11954-MONOMER
MetaCyc:EG11954-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtN
Gene namesi
Name:mdtN
Synonyms:yjcR
Ordered Locus Names:b4082, JW4043
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11954 mdtN

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 343PeriplasmicSequence analysisAdd BLAST310

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018831 – 343Multidrug resistance protein MdtNAdd BLAST343

Proteomic databases

PaxDbiP32716
PRIDEiP32716

Expressioni

Inductioni

Induced by LeuO, part of the mdtNO operon.1 Publication

Interactioni

Subunit structurei

Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP.

Protein-protein interaction databases

BioGridi4262953, 208 interactors
IntActiP32716, 3 interactors
STRINGi316385.ECDH10B_4273

Structurei

3D structure databases

ProteinModelPortaliP32716
SMRiP32716
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105J12 Bacteria
COG1566 LUCA
HOGENOMiHOG000112073
InParanoidiP32716
KOiK15549
OMAiQNTTGNW
PhylomeDBiP32716

Family and domain databases

InterProiView protein in InterPro
IPR005694 Emr
IPR030196 MdtN
PANTHERiPTHR30367:SF1 PTHR30367:SF1, 1 hit
TIGRFAMsiTIGR00998 8a0101, 1 hit

Sequencei

Sequence statusi: Complete.

P32716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTPKKAPR SKFPALLVVA LALVALVFVI WRVDSAPSTN DAYASADTID
60 70 80 90 100
VVPEVSGRIV ELAVTDNQAV KQGDLLFRID PRPYEANLAK AEASLAALDK
110 120 130 140 150
QIMLTQRSVD AQQFGADSVN ATVEKARAAA KQATDTLRRT EPLLKEGFVS
160 170 180 190 200
AEDVDRARTA QRAAEADLNA VLLQAQSAAS AVSGVDALVA QRAAVEADIA
210 220 230 240 250
LTKLHLEMAT VRAPFDGRVI SLKTSVGQFA SAMRPIFTLI DTRHWYVIAN
260 270 280 290 300
FRETDLKNIR SGTPATIRLM SDSGKTFEGK VDSIGYGVLP DDGGLVLGGL
310 320 330 340
PKVSRSINWV RVAQRFPVKI MVDKPDPEMF RIGASAVANL EPQ
Length:343
Mass (Da):36,908
Last modified:October 1, 1993 - v1
Checksum:iC599B8707C475FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA Translation: AAC43176.1
U00096 Genomic DNA Translation: AAD13465.1
AP009048 Genomic DNA Translation: BAE78084.1
PIRiA65217
RefSeqiNP_418506.1, NC_000913.3
WP_000446378.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAD13465; AAD13465; b4082
BAE78084; BAE78084; BAE78084
GeneIDi948598
KEGGiecj:JW4043
eco:b4082
PATRICifig|1411691.4.peg.2619

Similar proteinsi

Entry informationi

Entry nameiMDTN_ECOLI
AccessioniPrimary (citable) accession number: P32716
Secondary accession number(s): Q2M6M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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