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Protein

Multidrug resistance outer membrane protein MdtP

Gene

mdtP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.1 Publication

GO - Molecular functioni

  • lipid binding Source: InterPro
  • sulfathiazole transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • response to antibiotic Source: UniProtKB-KW
  • sulfathiazole transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG11952-MONOMER.
ECOL316407:JW4041-MONOMER.

Protein family/group databases

TCDBi1.B.17.3.9. the outer membrane factor (omf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance outer membrane protein MdtP
Gene namesi
Name:mdtP
Synonyms:yjcP
Ordered Locus Names:b4080, JW4041
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11952. mdtP.

Subcellular locationi

  • Cell outer membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323PROSITE-ProRule annotationAdd
BLAST
Chaini24 – 488465Multidrug resistance outer membrane protein MdtPPRO_0000031009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi24 – 241N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi24 – 241S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32714.
PRIDEiP32714.

Interactioni

Subunit structurei

Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP.

Protein-protein interaction databases

BioGridi4262951. 161 interactions.
IntActiP32714. 3 interactions.
STRINGi511145.b4080.

Structurei

3D structure databases

ProteinModelPortaliP32714.
SMRiP32714. Positions 37-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105ETP. Bacteria.
COG1538. LUCA.
HOGENOMiHOG000122243.
InParanoidiP32714.
KOiK15550.
OMAiGQIKETR.
PhylomeDBiP32714.

Family and domain databases

InterProiIPR003423. OMP_efflux.
IPR010131. RND_efflux_OM_lipoprot_NodT.
[Graphical view]
PfamiPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01845. outer_NodT. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL
60 70 80 90 100
ASSGWPQAQW WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL
110 120 130 140 150
DAGSQLQVAA LGMLNRQRVS ANGFLSPYSM DAPALGMDGP YYTEATVGLF
160 170 180 190 200
AGLDLDLWGV HRSAVAAAIG AHNAALAETA AVELSLATGV AQLYYSMQAS
210 220 230 240 250
YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA QILAVDKQIV
260 270 280 290 300
AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR
310 320 330 340 350
RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS
360 370 380 390 400
RQFNFIPGLK LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV
410 420 430 440 450
NGTRLQTLND EREMQAERVE ATRFTQRAAE AAYQRGLTSR LQATEARLPV
460 470 480
LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ AGPVVEKK
Length:488
Mass (Da):53,453
Last modified:July 15, 1998 - v2
Checksum:iC281EEDDD8595ADA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701G → A in AAC43174 (PubMed:8265357).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43174.1.
U00096 Genomic DNA. Translation: AAD13463.1.
AP009048 Genomic DNA. Translation: BAE78082.1.
PIRiG65216.
RefSeqiNP_418504.1. NC_000913.3.
WP_000610601.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAD13463; AAD13463; b4080.
BAE78082; BAE78082; BAE78082.
GeneIDi948583.
KEGGiecj:JW4041.
eco:b4080.
PATRICi32123713. VBIEscCol129921_4205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43174.1.
U00096 Genomic DNA. Translation: AAD13463.1.
AP009048 Genomic DNA. Translation: BAE78082.1.
PIRiG65216.
RefSeqiNP_418504.1. NC_000913.3.
WP_000610601.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32714.
SMRiP32714. Positions 37-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262951. 161 interactions.
IntActiP32714. 3 interactions.
STRINGi511145.b4080.

Protein family/group databases

TCDBi1.B.17.3.9. the outer membrane factor (omf) family.

Proteomic databases

PaxDbiP32714.
PRIDEiP32714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13463; AAD13463; b4080.
BAE78082; BAE78082; BAE78082.
GeneIDi948583.
KEGGiecj:JW4041.
eco:b4080.
PATRICi32123713. VBIEscCol129921_4205.

Organism-specific databases

EchoBASEiEB1895.
EcoGeneiEG11952. mdtP.

Phylogenomic databases

eggNOGiENOG4105ETP. Bacteria.
COG1538. LUCA.
HOGENOMiHOG000122243.
InParanoidiP32714.
KOiK15550.
OMAiGQIKETR.
PhylomeDBiP32714.

Enzyme and pathway databases

BioCyciEcoCyc:EG11952-MONOMER.
ECOL316407:JW4041-MONOMER.

Miscellaneous databases

PROiP32714.

Family and domain databases

InterProiIPR003423. OMP_efflux.
IPR010131. RND_efflux_OM_lipoprot_NodT.
[Graphical view]
PfamiPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01845. outer_NodT. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTP_ECOLI
AccessioniPrimary (citable) accession number: P32714
Secondary accession number(s): Q2M6M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.