Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance outer membrane protein MdtP

Gene

mdtP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.1 Publication

GO - Molecular functioni

  • efflux transmembrane transporter activity Source: InterPro
  • sulfathiazole transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • response to antibiotic Source: UniProtKB-KW
  • sulfathiazole transport Source: EcoCyc

Keywordsi

Biological processAntibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG11952-MONOMER

Protein family/group databases

TCDBi1.B.17.3.9 the outer membrane factor (omf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance outer membrane protein MdtP
Gene namesi
Name:mdtP
Synonyms:yjcP
Ordered Locus Names:b4080, JW4041
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11952 mdtP

Subcellular locationi

  • Cell outer membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
ChainiPRO_000003100924 – 488Multidrug resistance outer membrane protein MdtPAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32714
PRIDEiP32714

Interactioni

Subunit structurei

Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP.

Protein-protein interaction databases

BioGridi4262951, 161 interactors
IntActiP32714, 3 interactors
STRINGi316385.ECDH10B_4271

Structurei

3D structure databases

ProteinModelPortaliP32714
SMRiP32714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105ETP Bacteria
COG1538 LUCA
HOGENOMiHOG000122243
InParanoidiP32714
KOiK15550
OMAiKQSYNNG
PhylomeDBiP32714

Family and domain databases

InterProiView protein in InterPro
IPR003423 OMP_efflux
IPR010131 RND_efflux_OM_lipoprot_NodT
PfamiView protein in Pfam
PF02321 OEP, 2 hits
TIGRFAMsiTIGR01845 outer_NodT, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL
60 70 80 90 100
ASSGWPQAQW WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL
110 120 130 140 150
DAGSQLQVAA LGMLNRQRVS ANGFLSPYSM DAPALGMDGP YYTEATVGLF
160 170 180 190 200
AGLDLDLWGV HRSAVAAAIG AHNAALAETA AVELSLATGV AQLYYSMQAS
210 220 230 240 250
YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA QILAVDKQIV
260 270 280 290 300
AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR
310 320 330 340 350
RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS
360 370 380 390 400
RQFNFIPGLK LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV
410 420 430 440 450
NGTRLQTLND EREMQAERVE ATRFTQRAAE AAYQRGLTSR LQATEARLPV
460 470 480
LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ AGPVVEKK
Length:488
Mass (Da):53,453
Last modified:July 15, 1998 - v2
Checksum:iC281EEDDD8595ADA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170G → A in AAC43174 (PubMed:8265357).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA Translation: AAC43174.1
U00096 Genomic DNA Translation: AAD13463.1
AP009048 Genomic DNA Translation: BAE78082.1
PIRiG65216
RefSeqiNP_418504.1, NC_000913.3
WP_000610601.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAD13463; AAD13463; b4080
BAE78082; BAE78082; BAE78082
GeneIDi948583
KEGGiecj:JW4041
eco:b4080
PATRICifig|1411691.4.peg.2621

Similar proteinsi

Entry informationi

Entry nameiMDTP_ECOLI
AccessioniPrimary (citable) accession number: P32714
Secondary accession number(s): Q2M6M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health