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Protein

Putative cyclic-di-GMP phosphodiesterase YjcC

Gene

yjcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a c-di-GMP phosphodiesterase. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation.1 Publication

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

c-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:EG11938-MONOMER.
ECOL316407:JW4022-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cyclic-di-GMP phosphodiesterase YjcC (EC:3.1.4.52)
Gene namesi
Name:yjcC
Ordered Locus Names:b4061, JW4022
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11938. yjcC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Putative cyclic-di-GMP phosphodiesterase YjcCPRO_0000169719Add
BLAST

Proteomic databases

PaxDbiP32701.
PRIDEiP32701.

Expressioni

Inductioni

Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260840. 6 interactions.
DIPiDIP-12548N.
IntActiP32701. 2 interactions.
STRINGi511145.b4061.

Structurei

3D structure databases

ProteinModelPortaliP32701.
SMRiP32701. Positions 269-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 520253EALPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EAL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108M8H. Bacteria.
COG4943. LUCA.
HOGENOMiHOG000117610.
InParanoidiP32701.
OMAiRLIAHFY.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRARHQLL ALPGIIFLVL FPIILSLWIA FLWAKSEVNN QLRTFAQLAL
60 70 80 90 100
DKSELVIRQA DLVSDAAERY QGQVCTPAHQ KRMLNIIRGY LYINELIYAR
110 120 130 140 150
DNHFLCSSLI APVNGYTIAP ADYKREPNVS IYYYRDTPFF SGYKMTYMQR
160 170 180 190 200
GNYVAVINPL FWSEVMSDDP TLQWGVYDTV TKTFFSLSKE ASAATFSPLI
210 220 230 240 250
HLKDLTVQRN GYLYATVYST KRPIAAIVAT SYQRLITHFY NHLIFALPAG
260 270 280 290 300
ILGSLVLLLL WLRIRQNYLS PKRKLQRALE KHQLCLYYQP IIDIKTEKCI
310 320 330 340 350
GAEALLRWPG EQGQIMNPAE FIPLAEKEGM IEQITDYVID NVFRDLGDYL
360 370 380 390 400
ATHADRYVSI NLSASDFHTS RLIARINQKT EQYAVRPQQI KFEVTEHAFL
410 420 430 440 450
DVDKMTPIIL AFRQAGYEVA IDDFGIGYSN LHNLKSLNVD ILKIDKSFVE
460 470 480 490 500
TLTTHKTSHL IAEHIIELAH SLGLKTIAEG VETEEQVNWL RKRGVRYCQG
510 520
WFFAKAMPPQ VFMQWMEQLP ARELTRGQ
Length:528
Mass (Da):60,801
Last modified:November 1, 1997 - v2
Checksum:iF6E4819954912F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43155.1.
U00096 Genomic DNA. Translation: AAC77031.1.
AP009048 Genomic DNA. Translation: BAE78063.1.
PIRiD65214.
RefSeqiNP_418485.1. NC_000913.3.
WP_000019548.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77031; AAC77031; b4061.
BAE78063; BAE78063; BAE78063.
GeneIDi948568.
KEGGiecj:JW4022.
eco:b4061.
PATRICi32123667. VBIEscCol129921_4182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43155.1.
U00096 Genomic DNA. Translation: AAC77031.1.
AP009048 Genomic DNA. Translation: BAE78063.1.
PIRiD65214.
RefSeqiNP_418485.1. NC_000913.3.
WP_000019548.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32701.
SMRiP32701. Positions 269-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260840. 6 interactions.
DIPiDIP-12548N.
IntActiP32701. 2 interactions.
STRINGi511145.b4061.

Proteomic databases

PaxDbiP32701.
PRIDEiP32701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77031; AAC77031; b4061.
BAE78063; BAE78063; BAE78063.
GeneIDi948568.
KEGGiecj:JW4022.
eco:b4061.
PATRICi32123667. VBIEscCol129921_4182.

Organism-specific databases

EchoBASEiEB1882.
EcoGeneiEG11938. yjcC.

Phylogenomic databases

eggNOGiENOG4108M8H. Bacteria.
COG4943. LUCA.
HOGENOMiHOG000117610.
InParanoidiP32701.
OMAiRLIAHFY.
OrthoDBiEOG69GZGV.

Enzyme and pathway databases

BioCyciEcoCyc:EG11938-MONOMER.
ECOL316407:JW4022-MONOMER.

Miscellaneous databases

PROiP32701.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli."
    Sommerfeldt N., Possling A., Becker G., Pesavento C., Tschowri N., Hengge R.
    Microbiology 155:1318-1331(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, RPOS-DEPENDENCE.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress."
    Boehm A., Steiner S., Zaehringer F., Casanova A., Hamburger F., Ritz D., Keck W., Ackermann M., Schirmer T., Jenal U.
    Mol. Microbiol. 72:1500-1516(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN BIOFILM FORMATION.
    Strain: K12 / AB400.

Entry informationi

Entry nameiYJCC_ECOLI
AccessioniPrimary (citable) accession number: P32701
Secondary accession number(s): P76789, Q2M6P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.