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Protein

Fructose-like permease IIC component 2

Gene

frwC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:FRWC-MONOMER.
ECOL316407:JW3921-MONOMER.

Protein family/group databases

TCDBi4.A.2.1.10. the pts fructose-mannitol (fru) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-like permease IIC component 2
Alternative name(s):
PTS system fructose-like EIIC component 2
Gene namesi
Name:frwC
Synonyms:yijJ
Ordered Locus Names:b3949, JW3921
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11908. frwC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei60 – 8021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei99 – 11921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei135 – 15521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-like permease IIC component 2PRO_0000186506Add
BLAST

Proteomic databases

EPDiP32672.
PaxDbiP32672.

Interactioni

Protein-protein interaction databases

BioGridi4262060. 5 interactions.
STRINGi511145.b3949.

Structurei

3D structure databases

ProteinModelPortaliP32672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 344334PTS EIIC type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DM4. Bacteria.
COG1299. LUCA.
HOGENOMiHOG000227677.
KOiK11203.
OMAiIQNRITD.
OrthoDBiEOG6XDGX2.
PhylomeDBiP32672.

Family and domain databases

InterProiIPR013014. PTS_EIIC_2.
IPR006327. PTS_IIC_fruc.
[Graphical view]
TIGRFAMsiTIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELVQILKN TRQHLMTGVS HMIPFVVSGG ILLAVSVMLY GKGAVPDAVA
60 70 80 90 100
DPNLKKLFDI GVAGLTLMVP FLAAYIGYSI AERSALAPCA IGAWVGNSFG
110 120 130 140 150
AGFFGALIAG IIGGIVVHYL KKIPVHKVLR SVMPIFIIPI VGTLITAGIM
160 170 180 190 200
MWGLGEPVGA LTNSLTQWLQ GMQQGSIVML AVIMGLMLAF DMGGPVNKVA
210 220 230 240 250
YAFMLICVAQ GVYTVVAIAA VGICIPPLGM GLATLIGRKN FSAEERETGK
260 270 280 290 300
AALVMGCVGV TEGAIPFAAA DPLRVIPSIM VGSVCGAVTA ALVGAQCYAG
310 320 330 340 350
WGGLIVLPVV EGKLGYIAAV AVGAVVTAVC VNVLKSLARK NGSSTDEKED

DLDLDFEIN
Length:359
Mass (Da):37,086
Last modified:October 1, 1993 - v1
Checksum:i1CB60AF9FF6CCDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43055.1.
U00096 Genomic DNA. Translation: AAC76931.1.
AP009048 Genomic DNA. Translation: BAE77362.1.
PIRiH65201.
RefSeqiNP_418384.1. NC_000913.3.
WP_001004446.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76931; AAC76931; b3949.
BAE77362; BAE77362; BAE77362.
GeneIDi948448.
KEGGiecj:JW3921.
eco:b3949.
PATRICi32123419. VBIEscCol129921_4070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43055.1.
U00096 Genomic DNA. Translation: AAC76931.1.
AP009048 Genomic DNA. Translation: BAE77362.1.
PIRiH65201.
RefSeqiNP_418384.1. NC_000913.3.
WP_001004446.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32672.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262060. 5 interactions.
STRINGi511145.b3949.

Protein family/group databases

TCDBi4.A.2.1.10. the pts fructose-mannitol (fru) family.

Proteomic databases

EPDiP32672.
PaxDbiP32672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76931; AAC76931; b3949.
BAE77362; BAE77362; BAE77362.
GeneIDi948448.
KEGGiecj:JW3921.
eco:b3949.
PATRICi32123419. VBIEscCol129921_4070.

Organism-specific databases

EchoBASEiEB1852.
EcoGeneiEG11908. frwC.

Phylogenomic databases

eggNOGiENOG4105DM4. Bacteria.
COG1299. LUCA.
HOGENOMiHOG000227677.
KOiK11203.
OMAiIQNRITD.
OrthoDBiEOG6XDGX2.
PhylomeDBiP32672.

Enzyme and pathway databases

BioCyciEcoCyc:FRWC-MONOMER.
ECOL316407:JW3921-MONOMER.

Miscellaneous databases

PROiP32672.

Family and domain databases

InterProiIPR013014. PTS_EIIC_2.
IPR006327. PTS_IIC_fruc.
[Graphical view]
TIGRFAMsiTIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferase system genes revealed by bacterial genome analysis -- a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system."
    Reizer J., Reizer A., Saier M.H. Jr.
    Microbiology 141:961-971(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiPTFC2_ECOLI
AccessioniPrimary (citable) accession number: P32672
Secondary accession number(s): Q2M8P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 16, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.