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P32648 (VIP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
VIP peptides

Cleaved into the following 3 chains:

  1. Intestinal peptide PHI-42
  2. Intestinal peptide PHI-27
    Alternative name(s):
    Peptide histidine isoleucinamide 27
  3. Vasoactive intestinal peptide
    Short name=VIP
    Alternative name(s):
    Vasoactive intestinal polypeptide
Gene names
Name:Vip
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin By similarity. PHM also causes vasodilation.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glucagon family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processlearning or memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of potassium ion transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 9603988. Source: BHF-UCL

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein catabolic process

Inferred from direct assay PubMed 9603988. Source: BHF-UCL

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

regulation of protein localization

Inferred from direct assay PubMed 9603988. Source: BHF-UCL

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

regulation of signal transduction

Inferred from mutant phenotype PubMed 21737879. Source: MGI

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhormone activity

Inferred from direct assay PubMed 9603988. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Propeptide22 – 7958
PRO_0000011462
Peptide81 – 12242Intestinal peptide PHI-42 By similarity
PRO_0000011463
Peptide81 – 10727Intestinal peptide PHI-27
PRO_0000011464
Peptide125 – 15228Vasoactive intestinal peptide
PRO_0000011465
Propeptide156 – 17015
PRO_0000011466

Amino acid modifications

Modified residue1071Isoleucine amide
Modified residue1521Asparagine amide
Glycosylation1331N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict351V → VS Ref.2
Sequence conflict351V → VS Ref.3
Sequence conflict1221I → V AA sequence Ref.5

Sequences

Sequence LengthMass (Da)Tools
P32648 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 0164C831F8F5C73D

FASTA17019,049
        10         20         30         40         50         60 
MEARSKPQFL AFLILFSVLF SQSLAWPLFG PPSVVRLDDR MPFEGAGDPD QVSLKADSDI 

        70         80         90        100        110        120 
LQNPLAENGT PYYDVSRNAR HADGVFTSDY SRLLGQISAK KYLESLIGKR ISSSISEDPV 

       130        140        150        160        170 
PIKRHSDAVF TDNYTRLRKQ MAVKKYLNSI LNGKRSSEGD SADFLEELEK 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse."
Lamperti E.D., Rosen K.M., Villa-Komaroff L.
Brain Res. Mol. Brain Res. 9:217-231(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cecum.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[4]"High conservation of upstream regulatory sequences on the human and mouse vasoactive intestinal peptide (VIP) genes."
Sena M., Bravo D.T., Agoston D., Waschek J.A.
DNA Seq. 5:25-29(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
Strain: C57BL/6.
Tissue: Spleen.
[5]"Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells."
Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J.
Cell. Immunol. 151:369-378(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 119-129 AND 134-152.
Tissue: Mast cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK018599 mRNA. Translation: BAB31301.1.
BC089511 mRNA. Translation: AAH89511.1.
X74297 Genomic DNA. Translation: CAA52350.1.
PIRA60037.
RefSeqNP_035832.1. NM_011702.2.
XP_006512510.1. XM_006512447.1.
UniGeneMm.98916.

3D structure databases

ProteinModelPortalP32648.
SMRP32648. Positions 81-112, 125-153.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP32648.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019906; ENSMUSP00000019906; ENSMUSG00000019772.
GeneID22353.
KEGGmmu:22353.
UCSCuc007egk.1. mouse.

Organism-specific databases

CTD7432.
MGIMGI:98933. Vip.

Phylogenomic databases

eggNOGNOG44083.
GeneTreeENSGT00530000063592.
HOGENOMHOG000253943.
HOVERGENHBG018069.
InParanoidP32648.
KOK05264.
OrthoDBEOG7QVM4H.
PhylomeDBP32648.
TreeFamTF332804.

Gene expression databases

BgeeP32648.
CleanExMM_VIP.
GenevestigatorP32648.

Family and domain databases

InterProIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERPTHR11213:SF2. PTHR11213:SF2. 1 hit.
PfamPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio302647.
PROP32648.
SOURCESearch...

Entry information

Entry nameVIP_MOUSE
AccessionPrimary (citable) accession number: P32648
Secondary accession number(s): Q9D2Z7, Q9QUN1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot