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Protein

VIP peptides

Gene

Vip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHM also causes vasodilation.By similarity

GO - Molecular functioni

  1. hormone activity Source: BHF-UCL

GO - Biological processi

  1. learning or memory Source: Ensembl
  2. mRNA stabilization Source: AgBase
  3. negative regulation of apoptotic process Source: Ensembl
  4. negative regulation of potassium ion transport Source: Ensembl
  5. negative regulation of smooth muscle cell proliferation Source: Ensembl
  6. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  7. positive regulation of endothelial cell proliferation Source: Ensembl
  8. positive regulation of penile erection Source: Ensembl
  9. positive regulation of protein catabolic process Source: BHF-UCL
  10. positive regulation of vasodilation Source: Ensembl
  11. prolactin secretion Source: AgBase
  12. regulation of protein localization Source: BHF-UCL
  13. regulation of sensory perception of pain Source: Ensembl
  14. regulation of signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine isoleucinamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:Vip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98933. Vip.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Propeptidei22 – 7958PRO_0000011462Add
BLAST
Peptidei81 – 12242Intestinal peptide PHI-42By similarityPRO_0000011463Add
BLAST
Peptidei81 – 10727Intestinal peptide PHI-27PRO_0000011464Add
BLAST
Peptidei125 – 15228Vasoactive intestinal peptidePRO_0000011465Add
BLAST
Propeptidei156 – 17015PRO_0000011466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071Isoleucine amideBy similarity
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Modified residuei152 – 1521Asparagine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Glycoprotein

PTM databases

PhosphoSiteiP32648.

Expressioni

Gene expression databases

BgeeiP32648.
CleanExiMM_VIP.
GenevestigatoriP32648.

Structurei

3D structure databases

SMRiP32648. Positions 81-109, 125-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44083.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP32648.
KOiK05264.
OrthoDBiEOG7QVM4H.
PhylomeDBiP32648.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARSKPQFL AFLILFSVLF SQSLAWPLFG PPSVVRLDDR MPFEGAGDPD
60 70 80 90 100
QVSLKADSDI LQNPLAENGT PYYDVSRNAR HADGVFTSDY SRLLGQISAK
110 120 130 140 150
KYLESLIGKR ISSSISEDPV PIKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGD SADFLEELEK
Length:170
Mass (Da):19,049
Last modified:October 1, 1993 - v1
Checksum:i0164C831F8F5C73D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351V → VS (PubMed:16141072).Curated
Sequence conflicti35 – 351V → VS (PubMed:15489334).Curated
Sequence conflicti122 – 1221I → V AA sequence (PubMed:8402943).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018599 mRNA. Translation: BAB31301.1.
BC089511 mRNA. Translation: AAH89511.1.
X74297 Genomic DNA. Translation: CAA52350.1.
PIRiA60037.
RefSeqiNP_035832.1. NM_011702.2.
XP_006512510.1. XM_006512447.1.
UniGeneiMm.98916.

Genome annotation databases

GeneIDi22353.
KEGGimmu:22353.
UCSCiuc007egk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018599 mRNA. Translation: BAB31301.1.
BC089511 mRNA. Translation: AAH89511.1.
X74297 Genomic DNA. Translation: CAA52350.1.
PIRiA60037.
RefSeqiNP_035832.1. NM_011702.2.
XP_006512510.1. XM_006512447.1.
UniGeneiMm.98916.

3D structure databases

SMRiP32648. Positions 81-109, 125-153.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP32648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22353.
KEGGimmu:22353.
UCSCiuc007egk.1. mouse.

Organism-specific databases

CTDi7432.
MGIiMGI:98933. Vip.

Phylogenomic databases

eggNOGiNOG44083.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP32648.
KOiK05264.
OrthoDBiEOG7QVM4H.
PhylomeDBiP32648.
TreeFamiTF332804.

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi302647.
PROiP32648.
SOURCEiSearch...

Gene expression databases

BgeeiP32648.
CleanExiMM_VIP.
GenevestigatoriP32648.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse."
    Lamperti E.D., Rosen K.M., Villa-Komaroff L.
    Brain Res. Mol. Brain Res. 9:217-231(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  4. "High conservation of upstream regulatory sequences on the human and mouse vasoactive intestinal peptide (VIP) genes."
    Sena M., Bravo D.T., Agoston D., Waschek J.A.
    DNA Seq. 5:25-29(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
    Strain: C57BL/6.
    Tissue: Spleen.
  5. "Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells."
    Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J.
    Cell. Immunol. 151:369-378(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 119-129 AND 134-152, AMIDATION AT ASN-152.
    Tissue: Mast cell.

Entry informationi

Entry nameiVIP_MOUSE
AccessioniPrimary (citable) accession number: P32648
Secondary accession number(s): Q9D2Z7, Q9QUN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 1, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.