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P32648

- VIP_MOUSE

UniProt

P32648 - VIP_MOUSE

Protein

VIP peptides

Gene

Vip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
    PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin By similarity. PHM also causes vasodilation.By similarity

    GO - Molecular functioni

    1. hormone activity Source: BHF-UCL

    GO - Biological processi

    1. learning or memory Source: Ensembl
    2. negative regulation of apoptotic process Source: Ensembl
    3. negative regulation of potassium ion transport Source: Ensembl
    4. negative regulation of smooth muscle cell proliferation Source: Ensembl
    5. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
    6. positive regulation of endothelial cell proliferation Source: Ensembl
    7. positive regulation of penile erection Source: Ensembl
    8. positive regulation of protein catabolic process Source: BHF-UCL
    9. positive regulation of vasodilation Source: Ensembl
    10. regulation of protein localization Source: BHF-UCL
    11. regulation of sensory perception of pain Source: Ensembl
    12. regulation of signal transduction Source: MGI

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    VIP peptides
    Cleaved into the following 3 chains:
    Alternative name(s):
    Peptide histidine isoleucinamide 27
    Alternative name(s):
    Vasoactive intestinal polypeptide
    Gene namesi
    Name:Vip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:98933. Vip.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Propeptidei22 – 7958PRO_0000011462Add
    BLAST
    Peptidei81 – 12242Intestinal peptide PHI-42By similarityPRO_0000011463Add
    BLAST
    Peptidei81 – 10727Intestinal peptide PHI-27PRO_0000011464Add
    BLAST
    Peptidei125 – 15228Vasoactive intestinal peptidePRO_0000011465Add
    BLAST
    Propeptidei156 – 17015PRO_0000011466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei107 – 1071Isoleucine amideBy similarity
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Modified residuei152 – 1521Asparagine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Glycoprotein

    PTM databases

    PhosphoSiteiP32648.

    Expressioni

    Gene expression databases

    BgeeiP32648.
    CleanExiMM_VIP.
    GenevestigatoriP32648.

    Structurei

    3D structure databases

    ProteinModelPortaliP32648.
    SMRiP32648. Positions 81-109, 125-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44083.
    GeneTreeiENSGT00530000063592.
    HOGENOMiHOG000253943.
    HOVERGENiHBG018069.
    InParanoidiP32648.
    KOiK05264.
    OrthoDBiEOG7QVM4H.
    PhylomeDBiP32648.
    TreeFamiTF332804.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    IPR015523. VIP.
    [Graphical view]
    PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
    PfamiPF00123. Hormone_2. 2 hits.
    [Graphical view]
    SMARTiSM00070. GLUCA. 2 hits.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32648-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEARSKPQFL AFLILFSVLF SQSLAWPLFG PPSVVRLDDR MPFEGAGDPD    50
    QVSLKADSDI LQNPLAENGT PYYDVSRNAR HADGVFTSDY SRLLGQISAK 100
    KYLESLIGKR ISSSISEDPV PIKRHSDAVF TDNYTRLRKQ MAVKKYLNSI 150
    LNGKRSSEGD SADFLEELEK 170
    Length:170
    Mass (Da):19,049
    Last modified:October 1, 1993 - v1
    Checksum:i0164C831F8F5C73D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351V → VS(PubMed:16141072)Curated
    Sequence conflicti35 – 351V → VS(PubMed:15489334)Curated
    Sequence conflicti122 – 1221I → V AA sequence (PubMed:8402943)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018599 mRNA. Translation: BAB31301.1.
    BC089511 mRNA. Translation: AAH89511.1.
    X74297 Genomic DNA. Translation: CAA52350.1.
    PIRiA60037.
    RefSeqiNP_035832.1. NM_011702.2.
    XP_006512510.1. XM_006512447.1.
    UniGeneiMm.98916.

    Genome annotation databases

    EnsembliENSMUST00000019906; ENSMUSP00000019906; ENSMUSG00000019772.
    GeneIDi22353.
    KEGGimmu:22353.
    UCSCiuc007egk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018599 mRNA. Translation: BAB31301.1 .
    BC089511 mRNA. Translation: AAH89511.1 .
    X74297 Genomic DNA. Translation: CAA52350.1 .
    PIRi A60037.
    RefSeqi NP_035832.1. NM_011702.2.
    XP_006512510.1. XM_006512447.1.
    UniGenei Mm.98916.

    3D structure databases

    ProteinModelPortali P32648.
    SMRi P32648. Positions 81-109, 125-153.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P32648.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019906 ; ENSMUSP00000019906 ; ENSMUSG00000019772 .
    GeneIDi 22353.
    KEGGi mmu:22353.
    UCSCi uc007egk.1. mouse.

    Organism-specific databases

    CTDi 7432.
    MGIi MGI:98933. Vip.

    Phylogenomic databases

    eggNOGi NOG44083.
    GeneTreei ENSGT00530000063592.
    HOGENOMi HOG000253943.
    HOVERGENi HBG018069.
    InParanoidi P32648.
    KOi K05264.
    OrthoDBi EOG7QVM4H.
    PhylomeDBi P32648.
    TreeFami TF332804.

    Miscellaneous databases

    NextBioi 302647.
    PROi P32648.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32648.
    CleanExi MM_VIP.
    Genevestigatori P32648.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    IPR015523. VIP.
    [Graphical view ]
    PANTHERi PTHR11213:SF5. PTHR11213:SF5. 1 hit.
    Pfami PF00123. Hormone_2. 2 hits.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 2 hits.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse."
      Lamperti E.D., Rosen K.M., Villa-Komaroff L.
      Brain Res. Mol. Brain Res. 9:217-231(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    4. "High conservation of upstream regulatory sequences on the human and mouse vasoactive intestinal peptide (VIP) genes."
      Sena M., Bravo D.T., Agoston D., Waschek J.A.
      DNA Seq. 5:25-29(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
      Strain: C57BL/6.
      Tissue: Spleen.
    5. "Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells."
      Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J.
      Cell. Immunol. 151:369-378(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 119-129 AND 134-152, AMIDATION AT ASN-152.
      Tissue: Mast cell.

    Entry informationi

    Entry nameiVIP_MOUSE
    AccessioniPrimary (citable) accession number: P32648
    Secondary accession number(s): Q9D2Z7, Q9QUN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3