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Protein

VIP peptides

Gene

Vip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHM also causes vasodilation.By similarity

GO - Molecular functioni

  • hormone activity Source: BHF-UCL

GO - Biological processi

  • mRNA stabilization Source: AgBase
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of protein catabolic process Source: BHF-UCL
  • prolactin secretion Source: AgBase
  • regulation of protein localization Source: BHF-UCL
  • regulation of signal transduction Source: MGI

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine isoleucinamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:Vip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98933. Vip.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000001146222 – 79Add BLAST58
PeptideiPRO_000001146381 – 122Intestinal peptide PHI-42By similarityAdd BLAST42
PeptideiPRO_000001146481 – 107Intestinal peptide PHI-27Add BLAST27
PeptideiPRO_0000011465125 – 152Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011466156 – 170Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineBy similarity1
Modified residuei107Isoleucine amideBy similarity1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei152Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32648.
PRIDEiP32648.

PTM databases

PhosphoSitePlusiP32648.

Expressioni

Gene expression databases

CleanExiMM_VIP.

Interactioni

GO - Molecular functioni

  • hormone activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019906.

Structurei

3D structure databases

ProteinModelPortaliP32648.
SMRiP32648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP32648.
KOiK05264.
PhylomeDBiP32648.
TreeFamiTF332804.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiView protein in Pfam
PF00123. Hormone_2. 2 hits.
SMARTiView protein in SMART
SM00070. GLUCA. 2 hits.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARSKPQFL AFLILFSVLF SQSLAWPLFG PPSVVRLDDR MPFEGAGDPD
60 70 80 90 100
QVSLKADSDI LQNPLAENGT PYYDVSRNAR HADGVFTSDY SRLLGQISAK
110 120 130 140 150
KYLESLIGKR ISSSISEDPV PIKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGD SADFLEELEK
Length:170
Mass (Da):19,049
Last modified:October 1, 1993 - v1
Checksum:i0164C831F8F5C73D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35V → VS (PubMed:16141072).Curated1
Sequence conflicti35V → VS (PubMed:15489334).Curated1
Sequence conflicti122I → V AA sequence (PubMed:8402943).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018599 mRNA. Translation: BAB31301.1.
BC089511 mRNA. Translation: AAH89511.1.
X74297 Genomic DNA. Translation: CAA52350.1.
PIRiA60037.
RefSeqiNP_001300898.1. NM_001313969.1.
NP_035832.1. NM_011702.3.
XP_006512510.1. XM_006512447.1.
UniGeneiMm.98916.

Genome annotation databases

GeneIDi22353.
KEGGimmu:22353.
UCSCiuc007egk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiVIP_MOUSE
AccessioniPrimary (citable) accession number: P32648
Secondary accession number(s): Q9D2Z7, Q9QUN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 25, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families