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P32646

- COX2_VIGUN

UniProt

P32646 - COX2_VIGUN

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Protein

Cytochrome c oxidase subunit 2, mitochondrial

Gene

COX2

Organism
Vigna unguiculata (Cowpea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi309 – 3091Copper ACurated
Metal bindingi344 – 3441Copper ACurated
Metal bindingi348 – 3481Copper ACurated
Metal bindingi352 – 3521Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 163Mitochondrial intermembraneSequence Analysis
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 20420Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 376151Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 376Cytochrome c oxidase subunit 2, mitochondrialPRO_0000006044
Transit peptidei‹1 – ?MitochondrionSequence Analysis

Structurei

3D structure databases

ProteinModelPortaliP32646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
STVVGKCCKG NFGMSRFLLS NDFQRKLIVS GKESYYDHFS KRSYSSPSKA
60 70 80 90 100
PGTESTITST KIKMPNIGSE GFAFSSFLST VNKNSRMINF SSCLKTPVKP
110 120 130 140 150
EQIAANPVIL KMTTELEKIP RALRWMCGGF PAIALCDAPE PWQLGFQDAA
160 170 180 190 200
TPIMQGIMDL HHDIFFFLVQ ILVFVLWVLS RALWCFRSKI SPIPQRIVHG
210 220 230 240 250
TTIEILWTIL PSIILMFIAI PSFTLLYSMD DVVVDPAITI KAIGHQWYWS
260 270 280 290 300
YEYSDYNNSD EQSLAFDSYM VPEDDLELGQ LRLLEVDNRV VVPAKTHLRV
310 320 330 340 350
LITSADVLHS WAVPSLGVKC DAVPGRLNQI STFIQREGVY YGQCSEICGT
360 370
NHAFMPIVVE AVSTKDYGSW VSNQIQ
Length:376
Mass (Da):42,222
Last modified:July 25, 2003 - v2
Checksum:i8DE459D6C71B65B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211254 mRNA. Translation: AAF19523.1.
PIRiA39653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211254 mRNA. Translation: AAF19523.1 .
PIRi A39653.

3D structure databases

ProteinModelPortali P32646.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Adams K.L.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "RNA-mediated transfer of the gene coxII from the mitochondrion to the nucleus during flowering plant evolution."
    Nugent J.M., Palmer J.D.
    Cell 66:473-481(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-376.

Entry informationi

Entry nameiCOX2_VIGUN
AccessioniPrimary (citable) accession number: P32646
Secondary accession number(s): Q9LD17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 25, 2003
Last modified: November 26, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3