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Protein

Cytochrome c oxidase subunit 2, mitochondrial

Gene

COX2

Organism
Vigna unguiculata (Cowpea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi309Copper ACurated1
Metal bindingi344Copper ACurated1
Metal bindingi348Copper ACurated1
Metal bindingi352Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 163Mitochondrial intermembraneSequence analysis
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 204Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 376Mitochondrial intermembraneSequence analysisAdd BLAST151

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000006044? – 376Cytochrome c oxidase subunit 2, mitochondrial
Transit peptidei‹1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiP32646

Structurei

3D structure databases

ProteinModelPortaliP32646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STVVGKCCKG NFGMSRFLLS NDFQRKLIVS GKESYYDHFS KRSYSSPSKA
60 70 80 90 100
PGTESTITST KIKMPNIGSE GFAFSSFLST VNKNSRMINF SSCLKTPVKP
110 120 130 140 150
EQIAANPVIL KMTTELEKIP RALRWMCGGF PAIALCDAPE PWQLGFQDAA
160 170 180 190 200
TPIMQGIMDL HHDIFFFLVQ ILVFVLWVLS RALWCFRSKI SPIPQRIVHG
210 220 230 240 250
TTIEILWTIL PSIILMFIAI PSFTLLYSMD DVVVDPAITI KAIGHQWYWS
260 270 280 290 300
YEYSDYNNSD EQSLAFDSYM VPEDDLELGQ LRLLEVDNRV VVPAKTHLRV
310 320 330 340 350
LITSADVLHS WAVPSLGVKC DAVPGRLNQI STFIQREGVY YGQCSEICGT
360 370
NHAFMPIVVE AVSTKDYGSW VSNQIQ
Length:376
Mass (Da):42,222
Last modified:July 25, 2003 - v2
Checksum:i8DE459D6C71B65B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211254 mRNA Translation: AAF19523.1
PIRiA39653

Similar proteinsi

Entry informationi

Entry nameiCOX2_VIGUN
AccessioniPrimary (citable) accession number: P32646
Secondary accession number(s): Q9LD17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 25, 2003
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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