Reviewed, UniProtKB/Swiss-Prot P32622 (YEF1_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized kinase YEL041W
    EC=2.7.1.-

Gene names

Ordered Locus Names:	YEL041W
ORF Names:	SYGP-ORF17

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	Present with 300 molecules/cell in log phase SD medium. Ref.2
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Ligand	NAD NADP
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP biosynthetic process Inferred from direct assay. Source: SGD
Molecular function	NAD+ kinase activity Inferred from direct assay. Source: SGD NADH kinase activity Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UTR1	P21373	1	EBI-22350,EBI-20174

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Uncharacterized kinase YEL041W		PRO_0000120717

Sequences

	Sequence		Length	Mass (Da)
	P32622-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: E8301D466249DA27	FASTA	495	55,874
	10 20 30 40 50 60 MKTDRLLINA SPETCTKGDA EMDTMDTIDR MTSVKVLAEG KVLSNFEEPG LMRCGYHDAK 70 80 90 100 110 120 NWVRRLSSET IVGEDTSNLY PFYVDTAYDV RRLRKDLINA KVDLQVENLI IICNINDIST 130 140 150 160 170 180 VFLMREVVEW ILRNFHSITV YVQDIFKKST QFAVGDLCKD SNCSKNRVKY WSKEFVKKHD 190 200 210 220 230 240 SFFDLMITLG GDGTVLFASS IFTKDVPPIV PFALGSLGFL TNFEFQNFKE TLKHILTDEV 250 260 270 280 290 300 RINLRMRLQC KLYRRNKPEI DAATGRKICY IDFISEHHVL NEVTIDRGPA PCLSLLELYG 310 320 330 340 350 360 NDSLMTKVQG DGLIVATPTG STAYSLSAGG SLISPSVNAI AVTPICPHTL SFRPIILPDS 370 380 390 400 410 420 MELKVRVDMN SRGTSWVNFD GKDRVELKQG DYVVITASPY SVPTIESSAS EFFESISKNL 430 440 450 460 470 480 NWNDREEQKP FAHILSPKNQ EKYRLDSSKN GNDTISNPLE SSCISSDAQD EERKSVTETE 490 TEIVVERTRQ AHFAI

References

[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18779 Genomic DNA. Translation: AAB65001.1.
PIR	S30838.
RefSeq	NP_010873.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1885N.
IntAct	P32622. 6 interactions.
STRING	P32622.
Genome annotation databases
Ensembl	YEL041W; YEL041W; YEL041W; Saccharomyces cerevisiae. [Genome view]
GeneID	856670.
KEGG	sce:YEL041W.
NMPDR	fig|4932.3.peg.1924.
Organism-specific databases
CYGD	YEL041w.
SGD	S000000767. YEL041W.
Phylogenomic databases
HOGENOM	P32622.
OrthoDB	EOG9XD57D
Gene expression databases
ArrayExpress	P32622.
Genevestigator	P32622.
GermOnline	YEL041W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	982681.

Entry information

Entry name

YEF1_YEAST

Accession

Primary (citable) accession number: P32622

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)