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P32617

- IES6_YEAST

UniProt

P32617 - IES6_YEAST

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Protein

Chromatin-remodeling complex subunit IES6

Gene
IES6, YEL044W, SYGP-ORF13
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length.3 Publications

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. regulation of chromosome segregation Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin-remodeling complex subunit IES6
Alternative name(s):
Ino eighty subunit 6
Gene namesi
Name:IES6
Ordered Locus Names:YEL044W
ORF Names:SYGP-ORF13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL044w.
SGDiS000000770. IES6.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Chromatin-remodeling complex subunit IES6PRO_0000084158Add
BLAST

Proteomic databases

MaxQBiP32617.
PaxDbiP32617.

Expressioni

Gene expression databases

GenevestigatoriP32617.

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Protein-protein interaction databases

BioGridi36685. 37 interactions.
IntActiP32617. 4 interactions.
MINTiMINT-2731439.
STRINGi4932.YEL044W.

Structurei

3D structure databases

ProteinModelPortaliP32617.

Family & Domainsi

Sequence similaritiesi

Belongs to the IES6 family.

Phylogenomic databases

eggNOGiCOG5195.
HOGENOMiHOG000039089.
KOiK11667.
OMAiATEPRAW.
OrthoDBiEOG7DVDQB.

Family and domain databases

InterProiIPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view]
PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32617-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS    50
AHYKKPTRRH KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY 100
FSVEAPPSIR PAKKYCDVTG LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG 150
VDQEYLKLRG ANFVLK 166
Length:166
Mass (Da):18,533
Last modified:October 1, 1993 - v1
Checksum:i4B074DB4B10DC044
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321F → I in AAS56131. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18779 Genomic DNA. Translation: AAB64998.1.
AY557805 Genomic DNA. Translation: AAS56131.1.
BK006939 Genomic DNA. Translation: DAA07609.1.
PIRiS30833.
RefSeqiNP_010870.1. NM_001178859.1.

Genome annotation databases

EnsemblFungiiYEL044W; YEL044W; YEL044W.
GeneIDi856667.
KEGGisce:YEL044W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18779 Genomic DNA. Translation: AAB64998.1 .
AY557805 Genomic DNA. Translation: AAS56131.1 .
BK006939 Genomic DNA. Translation: DAA07609.1 .
PIRi S30833.
RefSeqi NP_010870.1. NM_001178859.1.

3D structure databases

ProteinModelPortali P32617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36685. 37 interactions.
IntActi P32617. 4 interactions.
MINTi MINT-2731439.
STRINGi 4932.YEL044W.

Proteomic databases

MaxQBi P32617.
PaxDbi P32617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL044W ; YEL044W ; YEL044W .
GeneIDi 856667.
KEGGi sce:YEL044W.

Organism-specific databases

CYGDi YEL044w.
SGDi S000000770. IES6.

Phylogenomic databases

eggNOGi COG5195.
HOGENOMi HOG000039089.
KOi K11667.
OMAi ATEPRAW.
OrthoDBi EOG7DVDQB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30164-MONOMER.

Miscellaneous databases

NextBioi 982672.

Gene expression databases

Genevestigatori P32617.

Family and domain databases

InterProi IPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view ]
PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
Pfami PF08265. YL1_C. 1 hit.
[Graphical view ]
SMARTi SM00993. YL1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
    Shen X., Ranallo R., Choi E., Wu C.
    Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair."
    Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X.
    Cell 119:767-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE INO80 COMPLEX.
  8. "Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae."
    Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K.
    Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex."
    Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F.
    Mol. Cell. Biol. 27:5639-5649(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIES6_YEAST
AccessioniPrimary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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