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P32617

- IES6_YEAST

UniProt

P32617 - IES6_YEAST

Protein

Chromatin-remodeling complex subunit IES6

Gene

IES6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length.3 Publications

    GO - Biological processi

    1. chromatin remodeling Source: SGD
    2. regulation of chromosome segregation Source: SGD
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30164-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromatin-remodeling complex subunit IES6
    Alternative name(s):
    Ino eighty subunit 6
    Gene namesi
    Name:IES6
    Ordered Locus Names:YEL044W
    ORF Names:SYGP-ORF13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL044w.
    SGDiS000000770. IES6.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Ino80 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Chromatin-remodeling complex subunit IES6PRO_0000084158Add
    BLAST

    Proteomic databases

    MaxQBiP32617.
    PaxDbiP32617.

    Expressioni

    Gene expression databases

    GenevestigatoriP32617.

    Interactioni

    Subunit structurei

    Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

    Protein-protein interaction databases

    BioGridi36685. 37 interactions.
    IntActiP32617. 4 interactions.
    MINTiMINT-2731439.
    STRINGi4932.YEL044W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32617.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IES6 family.Curated

    Phylogenomic databases

    eggNOGiCOG5195.
    HOGENOMiHOG000039089.
    KOiK11667.
    OMAiATEPRAW.
    OrthoDBiEOG7DVDQB.

    Family and domain databases

    InterProiIPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view]
    PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
    PfamiPF08265. YL1_C. 1 hit.
    [Graphical view]
    SMARTiSM00993. YL1_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS    50
    AHYKKPTRRH KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY 100
    FSVEAPPSIR PAKKYCDVTG LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG 150
    VDQEYLKLRG ANFVLK 166
    Length:166
    Mass (Da):18,533
    Last modified:October 1, 1993 - v1
    Checksum:i4B074DB4B10DC044
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321F → I in AAS56131. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18779 Genomic DNA. Translation: AAB64998.1.
    AY557805 Genomic DNA. Translation: AAS56131.1.
    BK006939 Genomic DNA. Translation: DAA07609.1.
    PIRiS30833.
    RefSeqiNP_010870.1. NM_001178859.1.

    Genome annotation databases

    EnsemblFungiiYEL044W; YEL044W; YEL044W.
    GeneIDi856667.
    KEGGisce:YEL044W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18779 Genomic DNA. Translation: AAB64998.1 .
    AY557805 Genomic DNA. Translation: AAS56131.1 .
    BK006939 Genomic DNA. Translation: DAA07609.1 .
    PIRi S30833.
    RefSeqi NP_010870.1. NM_001178859.1.

    3D structure databases

    ProteinModelPortali P32617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36685. 37 interactions.
    IntActi P32617. 4 interactions.
    MINTi MINT-2731439.
    STRINGi 4932.YEL044W.

    Proteomic databases

    MaxQBi P32617.
    PaxDbi P32617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL044W ; YEL044W ; YEL044W .
    GeneIDi 856667.
    KEGGi sce:YEL044W.

    Organism-specific databases

    CYGDi YEL044w.
    SGDi S000000770. IES6.

    Phylogenomic databases

    eggNOGi COG5195.
    HOGENOMi HOG000039089.
    KOi K11667.
    OMAi ATEPRAW.
    OrthoDBi EOG7DVDQB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30164-MONOMER.

    Miscellaneous databases

    NextBioi 982672.

    Gene expression databases

    Genevestigatori P32617.

    Family and domain databases

    InterProi IPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view ]
    PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
    Pfami PF08265. YL1_C. 1 hit.
    [Graphical view ]
    SMARTi SM00993. YL1_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
      Shen X., Ranallo R., Choi E., Wu C.
      Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair."
      Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X.
      Cell 119:767-775(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE INO80 COMPLEX.
    8. "Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae."
      Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K.
      Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex."
      Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F.
      Mol. Cell. Biol. 27:5639-5649(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiIES6_YEAST
    AccessioniPrimary (citable) accession number: P32617
    Secondary accession number(s): D3DLK5, Q6Q5Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1720 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3