P32617 (IES6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromatin-remodeling complex subunit IES6

Alternative name(s):
Ino eighty subunit 6

Gene names

Name:	IES6
Ordered Locus Names:	YEL044W
ORF Names:	SYGP-ORF13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length. Ref.7 Ref.8 Ref.9
Subunit structure	Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Ref.4
Subcellular location	Nucleus Ref.5.
Miscellaneous	Present with 1720 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the IES6 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Chromatin-remodeling complex subunit IES6		PRO_0000084158
Experimental info
	Sequence conflict	32	1	F → I in AAS56131. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P32617 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 4B074DB4B10DC044	FASTA	166	18,533
	10 20 30 40 50 60 MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS AHYKKPTRRH 70 80 90 100 110 120 KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY FSVEAPPSIR PAKKYCDVTG 130 140 150 160 LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG VDQEYLKLRG ANFVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Involvement of actin-related proteins in ATP-dependent chromatin remodeling." Shen X., Ranallo R., Choi E., Wu C. Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX, MASS SPECTROMETRY.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair." Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X. Cell 119:767-775(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION OF THE INO80 COMPLEX.
[8]	"Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae." Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K. Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex." Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F. Mol. Cell. Biol. 27:5639-5649(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18779 Genomic DNA. Translation: AAB64998.1. AY557805 Genomic DNA. Translation: AAS56131.1. BK006939 Genomic DNA. Translation: DAA07609.1.
PIR	S30833.
RefSeq	NP_010870.1. NM_001178859.1.
3D structure databases
ProteinModelPortal	P32617.
ModBase	Search...
Protein-protein interaction databases
IntAct	P32617. 1 interaction.
MINT	MINT-2731439.
STRING	4932.YEL044W.
Proteomic databases
PaxDb	P32617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YEL044W; YEL044W; YEL044W.
GeneID	856667.
KEGG	sce:YEL044W.
Organism-specific databases
CYGD	YEL044w.
SGD	S000000770. IES6.
Phylogenomic databases
eggNOG	COG5195.
HOGENOM	HOG000039089.
KO	K11667.
OrthoDB	EOG4W3WXQ.
Gene expression databases
Genevestigator	P32617.
GermOnline	YEL044W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013272. YL1_C. [Graphical view]
Pfam	PF08265. YL1_C. 1 hit. [Graphical view]
SMART	SM00993. YL1_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982672.

Entry information

Entry name

IES6_YEAST

Accession

Primary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program