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P32617

- IES6_YEAST

UniProt

P32617 - IES6_YEAST

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Protein

Chromatin-remodeling complex subunit IES6

Gene

IES6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length.3 Publications

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. regulation of chromosome segregation Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin-remodeling complex subunit IES6
Alternative name(s):
Ino eighty subunit 6
Gene namesi
Name:IES6
Ordered Locus Names:YEL044W
ORF Names:SYGP-ORF13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL044w.
SGDiS000000770. IES6.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Chromatin-remodeling complex subunit IES6PRO_0000084158Add
BLAST

Proteomic databases

MaxQBiP32617.
PaxDbiP32617.

Expressioni

Gene expression databases

GenevestigatoriP32617.

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Protein-protein interaction databases

BioGridi36685. 37 interactions.
IntActiP32617. 4 interactions.
MINTiMINT-2731439.
STRINGi4932.YEL044W.

Structurei

3D structure databases

ProteinModelPortaliP32617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IES6 family.Curated

Phylogenomic databases

eggNOGiCOG5195.
HOGENOMiHOG000039089.
InParanoidiP32617.
KOiK11667.
OMAiATEPRAW.
OrthoDBiEOG7DVDQB.

Family and domain databases

InterProiIPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view]
PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32617 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS
60 70 80 90 100
AHYKKPTRRH KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY
110 120 130 140 150
FSVEAPPSIR PAKKYCDVTG LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG
160
VDQEYLKLRG ANFVLK
Length:166
Mass (Da):18,533
Last modified:October 1, 1993 - v1
Checksum:i4B074DB4B10DC044
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321F → I in AAS56131. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18779 Genomic DNA. Translation: AAB64998.1.
AY557805 Genomic DNA. Translation: AAS56131.1.
BK006939 Genomic DNA. Translation: DAA07609.1.
PIRiS30833.
RefSeqiNP_010870.1. NM_001178859.1.

Genome annotation databases

EnsemblFungiiYEL044W; YEL044W; YEL044W.
GeneIDi856667.
KEGGisce:YEL044W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18779 Genomic DNA. Translation: AAB64998.1 .
AY557805 Genomic DNA. Translation: AAS56131.1 .
BK006939 Genomic DNA. Translation: DAA07609.1 .
PIRi S30833.
RefSeqi NP_010870.1. NM_001178859.1.

3D structure databases

ProteinModelPortali P32617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36685. 37 interactions.
IntActi P32617. 4 interactions.
MINTi MINT-2731439.
STRINGi 4932.YEL044W.

Proteomic databases

MaxQBi P32617.
PaxDbi P32617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL044W ; YEL044W ; YEL044W .
GeneIDi 856667.
KEGGi sce:YEL044W.

Organism-specific databases

CYGDi YEL044w.
SGDi S000000770. IES6.

Phylogenomic databases

eggNOGi COG5195.
HOGENOMi HOG000039089.
InParanoidi P32617.
KOi K11667.
OMAi ATEPRAW.
OrthoDBi EOG7DVDQB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30164-MONOMER.

Miscellaneous databases

NextBioi 982672.

Gene expression databases

Genevestigatori P32617.

Family and domain databases

InterProi IPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view ]
PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
Pfami PF08265. YL1_C. 1 hit.
[Graphical view ]
SMARTi SM00993. YL1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
    Shen X., Ranallo R., Choi E., Wu C.
    Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair."
    Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X.
    Cell 119:767-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE INO80 COMPLEX.
  8. "Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae."
    Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K.
    Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex."
    Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F.
    Mol. Cell. Biol. 27:5639-5649(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIES6_YEAST
AccessioniPrimary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3