P32617 (IES6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromatin-remodeling complex subunit IES6

Alternative name(s):
Ino eighty subunit 6

Gene names

Name:	IES6
Ordered Locus Names:	YEL044W
ORF Names:	SYGP-ORF13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length. Ref.7 Ref.8 Ref.9
Subunit structure	Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
Subcellular location	Nucleus Ref.5.
Miscellaneous	Present with 1720 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the IES6 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Chromatin-remodeling complex subunit IES6		PRO_0000084158
Experimental info
	Sequence conflict	32	1	F → I in AAS56131. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P32617 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 4B074DB4B10DC044	FASTA	166	18,533
	10 20 30 40 50 60 MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS AHYKKPTRRH 70 80 90 100 110 120 KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY FSVEAPPSIR PAKKYCDVTG 130 140 150 160 LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG VDQEYLKLRG ANFVLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Involvement of actin-related proteins in ATP-dependent chromatin remodeling." Shen X., Ranallo R., Choi E., Wu C. Mol. Cell 12:147-155(2003) [PubMed: 12887900] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX, MASS SPECTROMETRY.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair." Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X. Cell 119:767-775(2004) [PubMed: 15607974] [Abstract] Cited for: FUNCTION OF THE INO80 COMPLEX.
[8]	"Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae." Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K. Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed: 15184655] [Abstract] Cited for: FUNCTION.
[9]	"Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex." Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F. Mol. Cell. Biol. 27:5639-5649(2007) [PubMed: 17562861] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18779 Genomic DNA. Translation: AAB64998.1. AY557805 Genomic DNA. Translation: AAS56131.1. BK006939 Genomic DNA. Translation: DAA07609.1.
PIR	S30833.
RefSeq	NP_010870.1. NM_001178859.1.
3D structure databases
ProteinModelPortal	P32617.
ModBase	Search...
Protein-protein interaction databases
IntAct	P32617. 1 interaction.
MINT	MINT-2731439.
STRING	P32617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YEL044W; YEL044W; YEL044W.
GeneID	856667.
KEGG	sce:YEL044W.
NMPDR	fig|4932.3.peg.1921.
Organism-specific databases
CYGD	YEL044w.
SGD	S000000770. IES6.
Phylogenomic databases
eggNOG	fuNOG12471.
GeneTree	EFGT00050000005267.
HOGENOM	HBG505918.
OrthoDB	EOG4W3WXQ.
Gene expression databases
ArrayExpress	P32617.
Genevestigator	P32617.
GermOnline	YEL044W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013272. YL1_C. [Graphical view]
KO	K11667.
Pfam	PF08265. YL1_C. 1 hit. [Graphical view]
SMART	SM00993. YL1_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982672.

Entry information

Entry name

IES6_YEAST

Accession

Primary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program