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P32617 (IES6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromatin-remodeling complex subunit IES6
Alternative name(s):
Ino eighty subunit 6
Gene names
Name:IES6
Ordered Locus Names:YEL044W
ORF Names:SYGP-ORF13
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length. Ref.7 Ref.8 Ref.9

Subunit structure

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Ref.4

Subcellular location

Nucleus Ref.5.

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the IES6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Chromatin-remodeling complex subunit IES6
PRO_0000084158

Experimental info

Sequence conflict321F → I in AAS56131. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P32617 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 4B074DB4B10DC044

FASTA16618,533
        10         20         30         40         50         60 
MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS AHYKKPTRRH 

        70         80         90        100        110        120 
KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY FSVEAPPSIR PAKKYCDVTG 

       130        140        150        160 
LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG VDQEYLKLRG ANFVLK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
Shen X., Ranallo R., Choi E., Wu C.
Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair."
Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F., Haber J.E., Shen X.
Cell 119:767-775(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE INO80 COMPLEX.
[8]"Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae."
Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K.
Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex."
Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J., Shen X., Lue N.F.
Mol. Cell. Biol. 27:5639-5649(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18779 Genomic DNA. Translation: AAB64998.1.
AY557805 Genomic DNA. Translation: AAS56131.1.
BK006939 Genomic DNA. Translation: DAA07609.1.
PIRS30833.
RefSeqNP_010870.1. NM_001178859.1.

3D structure databases

ProteinModelPortalP32617.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36685. 37 interactions.
IntActP32617. 4 interactions.
MINTMINT-2731439.
STRING4932.YEL044W.

Proteomic databases

PaxDbP32617.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL044W; YEL044W; YEL044W.
GeneID856667.
KEGGsce:YEL044W.

Organism-specific databases

CYGDYEL044w.
SGDS000000770. IES6.

Phylogenomic databases

eggNOGCOG5195.
HOGENOMHOG000039089.
KOK11667.
OrthoDBEOG7DVDQB.

Enzyme and pathway databases

BioCycYEAST:G3O-30164-MONOMER.

Gene expression databases

GenevestigatorP32617.

Family and domain databases

InterProIPR013272. YL1_C.
[Graphical view]
PfamPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTSM00993. YL1_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982672.

Entry information

Entry nameIES6_YEAST
AccessionPrimary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families