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Protein

Chromatin-remodeling complex subunit IES6

Gene

IES6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length.3 Publications

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chromatin remodeling Source: SGD
  • regulation of chromosome segregation Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30164-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin-remodeling complex subunit IES6
Alternative name(s):
Ino eighty subunit 6
Gene namesi
Name:IES6
Ordered Locus Names:YEL044W
ORF Names:SYGP-ORF13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL044W
SGDiS000000770 IES6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841581 – 166Chromatin-remodeling complex subunit IES6Add BLAST166

Proteomic databases

MaxQBiP32617
PaxDbiP32617
PRIDEiP32617

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Protein-protein interaction databases

BioGridi36685, 43 interactors
IntActiP32617, 4 interactors
MINTiP32617
STRINGi4932.YEL044W

Structurei

3D structure databases

ProteinModelPortaliP32617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IES6 family.Curated

Phylogenomic databases

HOGENOMiHOG000039089
InParanoidiP32617
KOiK11667
OMAiWKPNQRR
OrthoDBiEOG092C4LX2

Family and domain databases

InterProiView protein in InterPro
IPR029525 INO80C/Ies6
IPR013272 Vps72/YL1_C
PANTHERiPTHR31200 PTHR31200, 1 hit
PfamiView protein in Pfam
PF08265 YL1_C, 1 hit
SMARTiView protein in SMART
SM00993 YL1_C, 1 hit

Sequencei

Sequence statusi: Complete.

P32617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS
60 70 80 90 100
AHYKKPTRRH KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY
110 120 130 140 150
FSVEAPPSIR PAKKYCDVTG LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG
160
VDQEYLKLRG ANFVLK
Length:166
Mass (Da):18,533
Last modified:October 1, 1993 - v1
Checksum:i4B074DB4B10DC044
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32F → I in AAS56131 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA Translation: AAB64998.1
AY557805 Genomic DNA Translation: AAS56131.1
BK006939 Genomic DNA Translation: DAA07609.1
PIRiS30833
RefSeqiNP_010870.1, NM_001178859.1

Genome annotation databases

EnsemblFungiiYEL044W; YEL044W; YEL044W
GeneIDi856667
KEGGisce:YEL044W

Similar proteinsi

Entry informationi

Entry nameiIES6_YEAST
AccessioniPrimary (citable) accession number: P32617
Secondary accession number(s): D3DLK5, Q6Q5Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health