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P32616 (YEF5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein YEL045C
Gene names
Ordered Locus Names:YEL045C
ORF Names:SYGP-ORF33
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for optimal growth under alkaline conditions.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Repressed after alkaline pH stress. Ref.4

Disruption phenotype

Growth defect under alkaline conditions and citric acid stress. Ref.5 Ref.6 Ref.7

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 141141Uncharacterized protein YEL045C
PRO_0000202606

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane67 – 8721Helical; Potential
Nucleotide binding15 – 228ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P32616 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: F6604AC5343A5D5C

FASTA14116,469
        10         20         30         40         50         60 
MKCHAKRTLA FLATALPLSG KSRACTRTPQ SFASGFRAAA PFLFSRCFAL CITHCALFHL 

        70         80         90        100        110        120 
PYSFTGFSFY FFVFFRLFLH WIYAFCICNS TYVYIYKQVL SLPVKSSMCP SRLSCSVWYR 

       130        140 
VILTYIYVHC FRWLVRNHLL S 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling."
Serrano R., Ruiz A., Bernal D., Chambers J.R., Arino J.
Mol. Microbiol. 46:1319-1333(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment."
Serrano R., Bernal D., Simon E., Arino J.
J. Biol. Chem. 279:19698-19704(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[6]"Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress."
Lawrence C.L., Botting C.H., Antrobus R., Coote P.J.
Mol. Cell. Biol. 24:3307-3323(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[7]"A genomic screen for yeast vacuolar membrane ATPase mutants."
Sambade M., Alba M., Smardon A.M., West R.W., Kane P.M.
Genetics 170:1539-1551(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18779 Genomic DNA. Translation: AAB64997.1.
AY558443 Genomic DNA. Translation: AAS56769.1.
BK006939 Genomic DNA. No translation available.
PIRS30832.

3D structure databases

ProteinModelPortalP32616.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4932.YEL045C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL045C; YEL045C; YEL045C.

Organism-specific databases

CYGDYEL045c.
SGDS000000771. YEL045C.

Phylogenomic databases

OrthoDBEOG741ZF0.

Gene expression databases

GenevestigatorP32616.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameYEF5_YEAST
AccessionPrimary (citable) accession number: P32616
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD