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Protein

Uncharacterized protein YEL045C

Gene

YEL045C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for optimal growth under alkaline conditions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein YEL045C
Gene namesi
Ordered Locus Names:YEL045C
ORF Names:SYGP-ORF33
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYEL045c.
SGDiS000000771. YEL045C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Growth defect under alkaline conditions and citric acid stress.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Uncharacterized protein YEL045CPRO_0000202606Add
BLAST

Expressioni

Inductioni

Repressed after alkaline pH stress.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi4932.YEL045C.

Structurei

3D structure databases

ProteinModelPortaliP32616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG741ZF0.

Sequencei

Sequence statusi: Complete.

P32616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCHAKRTLA FLATALPLSG KSRACTRTPQ SFASGFRAAA PFLFSRCFAL
60 70 80 90 100
CITHCALFHL PYSFTGFSFY FFVFFRLFLH WIYAFCICNS TYVYIYKQVL
110 120 130 140
SLPVKSSMCP SRLSCSVWYR VILTYIYVHC FRWLVRNHLL S
Length:141
Mass (Da):16,469
Last modified:October 1, 1993 - v1
Checksum:iF6604AC5343A5D5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA. Translation: AAB64997.1.
AY558443 Genomic DNA. Translation: AAS56769.1.
BK006939 Genomic DNA. No translation available.
PIRiS30832.

Genome annotation databases

EnsemblFungiiYEL045C; YEL045C; YEL045C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA. Translation: AAB64997.1.
AY558443 Genomic DNA. Translation: AAS56769.1.
BK006939 Genomic DNA. No translation available.
PIRiS30832.

3D structure databases

ProteinModelPortaliP32616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4932.YEL045C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL045C; YEL045C; YEL045C.

Organism-specific databases

CYGDiYEL045c.
SGDiS000000771. YEL045C.

Phylogenomic databases

OrthoDBiEOG741ZF0.

Miscellaneous databases

PROiP32616.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling."
    Serrano R., Ruiz A., Bernal D., Chambers J.R., Arino J.
    Mol. Microbiol. 46:1319-1333(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment."
    Serrano R., Bernal D., Simon E., Arino J.
    J. Biol. Chem. 279:19698-19704(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress."
    Lawrence C.L., Botting C.H., Antrobus R., Coote P.J.
    Mol. Cell. Biol. 24:3307-3323(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "A genomic screen for yeast vacuolar membrane ATPase mutants."
    Sambade M., Alba M., Smardon A.M., West R.W., Kane P.M.
    Genetics 170:1539-1551(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiYEF5_YEAST
AccessioniPrimary (citable) accession number: P32616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.