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Protein

TRAPP-associated protein TCA17

Gene

TCA17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required, together with the TRAPP II subunit TRS33, for TRAPP II complex assembly or stability, and for proper Golgi localization of TRAPP and the Rab GTPase YPT31.2 Publications

GO - Biological processi

  • early endosome to Golgi transport Source: SGD
  • ER to Golgi vesicle-mediated transport Source: InterPro
  • protein complex assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TRAPP-associated protein TCA17
Alternative name(s):
17 kDa TRAPP complex-associated protein
Gene namesi
Name:TCA17
Ordered Locus Names:YEL048C
ORF Names:SYGP-ORF36
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL048C.
SGDiS000000774. TCA17.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • Golgi apparatus Source: SGD
  • TRAPPII protein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152TRAPP-associated protein TCA17PRO_0000202605Add
BLAST

Proteomic databases

MaxQBiP32613.

Interactioni

Subunit structurei

Interacts with the TRAPP II complex; TRAPP II subunits TRS33 and TRS65 are required for this interaction.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRS130Q036607EBI-22370,EBI-19461

Protein-protein interaction databases

BioGridi36682. 28 interactions.
DIPiDIP-5288N.
IntActiP32613. 11 interactions.
MINTiMINT-491635.

Structurei

Secondary structure

1
152
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 116Combined sources
Beta strandi17 – 215Combined sources
Helixi33 – 4816Combined sources
Beta strandi57 – 604Combined sources
Beta strandi64 – 696Combined sources
Beta strandi72 – 787Combined sources
Turni80 – 823Combined sources
Beta strandi85 – 917Combined sources
Helixi92 – 943Combined sources
Helixi99 – 12022Combined sources
Helixi125 – 1273Combined sources
Helixi130 – 14516Combined sources
Helixi149 – 1524Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PR6X-ray1.80A1-152[»]
ProteinModelPortaliP32613.
SMRiP32613. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000000836.
InParanoidiP32613.
OMAiRTEMEHI.
OrthoDBiEOG7966V4.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

P32613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRPCFVSL IDESDKPILI YVPNEAENEM NDVLKYNVLS NISLDYFESA
60 70 80 90 100
LVEWHSLDSK PLLKSIFQLE GVSVFAMLIK QTGLKIVIGF EQKSLSGADD
110 120 130 140 150
EFEAINQIFE TVRKIYIRVK CNPLLVSGDE KSIIKSLERK FDELFISTEV

EL
Length:152
Mass (Da):17,354
Last modified:October 1, 1993 - v1
Checksum:iF7AF8E6EC34F193D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → T in AAS56768 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA. Translation: AAB64994.1.
AY558442 Genomic DNA. Translation: AAS56768.1.
BK006939 Genomic DNA. Translation: DAA07606.1.
PIRiS30829.
RefSeqiNP_010866.1. NM_001178863.1.

Genome annotation databases

EnsemblFungiiYEL048C; YEL048C; YEL048C.
GeneIDi856663.
KEGGisce:YEL048C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA. Translation: AAB64994.1.
AY558442 Genomic DNA. Translation: AAS56768.1.
BK006939 Genomic DNA. Translation: DAA07606.1.
PIRiS30829.
RefSeqiNP_010866.1. NM_001178863.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PR6X-ray1.80A1-152[»]
ProteinModelPortaliP32613.
SMRiP32613. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36682. 28 interactions.
DIPiDIP-5288N.
IntActiP32613. 11 interactions.
MINTiMINT-491635.

Proteomic databases

MaxQBiP32613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL048C; YEL048C; YEL048C.
GeneIDi856663.
KEGGisce:YEL048C.

Organism-specific databases

EuPathDBiFungiDB:YEL048C.
SGDiS000000774. TCA17.

Phylogenomic databases

HOGENOMiHOG000000836.
InParanoidiP32613.
OMAiRTEMEHI.
OrthoDBiEOG7966V4.

Enzyme and pathway databases

BioCyciYEAST:G3O-30166-MONOMER.

Miscellaneous databases

PROiP32613.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Identification of the novel TRAPP associated protein Tca17."
    Montpetit B., Conibear E.
    Traffic 10:713-723(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH THE TRAPP II COMPLEX, SUBCELLULAR LOCATION.
  6. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
    Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
    Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH THE TRAPP II COMPLEX.

Entry informationi

Entry nameiTCA17_YEAST
AccessioniPrimary (citable) accession number: P32613
Secondary accession number(s): D3DLK2, Q6Q561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.