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P32600

- TOR2_YEAST

UniProt

P32600 - TOR2_YEAST

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Protein
Serine/threonine-protein kinase TOR2
Gene
TOR2, DRR2, TSC14, YKL203C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog, component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway by activating the RHO1 guanine nucleotide exchange factor ROM2. TORC2 phosphorylates the AGC kinase YPK2, an upstream effector of the cell integrity pathway. TORC2 negatively regulates calcineurin-dependent stress signaling via phosphorylation of its effector SLM1-SLM2.15 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.1 Publication

GO - Molecular functioni

  1. 1-phosphatidylinositol 4-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: InterPro
  4. protein binding Source: IntAct
  5. protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  1. TOR signaling Source: SGD
  2. actin filament reorganization involved in cell cycle Source: SGD
  3. cytoskeleton organization Source: SGD
  4. establishment or maintenance of actin cytoskeleton polarity Source: SGD
  5. negative regulation of autophagy Source: SGD
  6. positive regulation of Rho guanyl-nucleotide exchange factor activity Source: SGD
  7. positive regulation of Rho protein signal transduction Source: SGD
  8. positive regulation of endocytosis Source: SGD
  9. protein phosphorylation Source: GOC
  10. regulation of cell cycle Source: SGD
  11. regulation of cell growth Source: SGD
  12. ribosome biogenesis Source: SGD
  13. signal transduction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31962-MONOMER.
BRENDAi2.7.1.137. 984.
ReactomeiREACT_188481. S6K1-mediated signalling.
REACT_188925. CD28 dependent PI3K/Akt signaling.
REACT_188931. PIP3 activates AKT signaling.
REACT_219346. HSF1-dependent transactivation.
REACT_223756. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TOR2 (EC:2.7.1.67, EC:2.7.11.1)
Alternative name(s):
Dominant rapamycin resistance protein 2
Phosphatidylinositol 4-kinase TOR2
Short name:
PI4-kinase TOR2
Short name:
PI4K TOR2
Short name:
PtdIns-4-kinase TOR2
Target of rapamycin kinase 2
Temperature-sensitive CSG2 suppressor protein 14
Gene namesi
Name:TOR2
Synonyms:DRR2, TSC14
Ordered Locus Names:YKL203C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL203c.
SGDiS000001686. TOR2.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
Note: Also localizes to membranous structures both proximal to, yet distinct from, the plasma membrane as well as within the cell interior, probably endosomal or Golgi membranes.3 Publications

GO - Cellular componenti

  1. TORC1 complex Source: SGD
  2. TORC2 complex Source: SGD
  3. cytoplasm Source: SGD
  4. extrinsic component of cytoplasmic side of plasma membrane Source: SGD
  5. fungal-type vacuole membrane Source: SGD
  6. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1975 – 19751S → I in TOR2-1; confers resistance to rapamycin. 1 Publication
Mutagenesisi2129 – 21291G → R: Causes defect in receptor endocytosis. 1 Publication
Mutagenesisi2279 – 22791D → A: Loss of function. 1 Publication
Mutagenesisi2298 – 22981D → E: Loss of kinase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24742474Serine/threonine-protein kinase TOR2
PRO_0000088815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32600.
PaxDbiP32600.
PeptideAtlasiP32600.

Expressioni

Gene expression databases

GenevestigatoriP32600.

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin. The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. Interacts with SLM1 and SLM2.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AVO1Q082364EBI-19385,EBI-29284
AVO2Q047494EBI-19385,EBI-28131
BIT61P470412EBI-19385,EBI-25889
LST8P413187EBI-19385,EBI-28598
TAP42Q043724EBI-19385,EBI-18926
TSC11P400615EBI-19385,EBI-22621

Protein-protein interaction databases

BioGridi33920. 250 interactions.
DIPiDIP-2332N.
IntActiP32600. 24 interactions.
MINTiMINT-2843476.
STRINGi4932.YKL203C.

Structurei

3D structure databases

ProteinModelPortaliP32600.
SMRiP32600. Positions 1405-1447, 1955-2420, 2442-2474.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati588 – 62639HEAT 1
Add
BLAST
Repeati636 – 67439HEAT 2
Add
BLAST
Repeati676 – 71035HEAT 3
Add
BLAST
Repeati756 – 79338HEAT 4
Add
BLAST
Repeati797 – 83539HEAT 5
Add
BLAST
Repeati841 – 87939HEAT 6
Add
BLAST
Repeati917 – 95539HEAT 7
Add
BLAST
Repeati1039 – 107638HEAT 8
Add
BLAST
Repeati1079 – 111638HEAT 9
Add
BLAST
Repeati1118 – 115538HEAT 10
Add
BLAST
Repeati1292 – 133140HEAT 11
Add
BLAST
Domaini1338 – 1922585FAT
Add
BLAST
Domaini2123 – 2441319PI3K/PI4K
Add
BLAST
Domaini2442 – 247433FATC
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 11 HEAT repeats.
Contains 1 PI3K/PI4K domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
GeneTreeiENSGT00720000108744.
HOGENOMiHOG000163215.
KOiK07203.
OMAiTYKQNIG.
OrthoDBiEOG7Z3FCR.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view]
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 9 hits.
SSF56112. SSF56112. 3 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32600-1 [UniParc]FASTAAdd to Basket

« Hide

MNKYINKYTT PPNLLSLRQR AEGKHRTRKK LTHKSHSHDD EMSTTSNTDS     50
NHNGPNDSGR VITGSAGHIG KISFVDSELD TTFSTLNLIF DKLKSDVPQE 100
RASGANELST TLTSLAREVS AEQFQRFSNS LNNKIFELIH GFTSSEKIGG 150
ILAVDTLISF YLSTEELPNQ TSRLANYLRV LIPSSDIEVM RLAANTLGRL 200
TVPGGTLTSD FVEFEVRTCI DWLTLTADNN SSSSKLEYRR HAALLIIKAL 250
ADNSPYLLYP YVNSILDNIW VPLRDAKLII RLDAAVALGK CLTIIQDRDP 300
ALGKQWFQRL FQGCTHGLSL NTNDSVHATL LVFRELLSLK APYLRDKYDD 350
IYKSTMKYKE YKFDVIRREV YAILPLLAAF DPAIFTKKYL DRIMVHYLRY 400
LKNIDMNAAN NSDKPFILVS IGDIAFEVGS SISPYMTLIL DNIREGLRTK 450
FKVRKQFEKD LFYCIGKLAC ALGPAFAKHL NKDLLNLMLN CPMSDHMQET 500
LMILNEKIPS LESTVNSRIL NLLSISLSGE KFIQSNQYDF NNQFSIEKAR 550
KSRNQSFMKK TGESNDDITD AQILIQCFKM LQLIHHQYSL TEFVRLITIS 600
YIEHEDSSVR KLAALTSCDL FIKDDICKQT SVHALHSVSE VLSKLLMIAI 650
TDPVAEIRLE ILQHLGSNFD PQLAQPDNLR LLFMALNDEI FGIQLEAIKI 700
IGRLSSVNPA YVVPSLRKTL LELLTQLKFS NMPKKKEESA TLLCTLINSS 750
DEVAKPYIDP ILDVILPKCQ DASSAVASTA LKVLGELSVV GGKEMTRYLK 800
ELMPLIINTF QDQSNSFKRD AALTTLGQLA ASSGYVVGPL LDYPELLGIL 850
INILKTENNP HIRRGTVRLI GILGALDPYK HREIEVTSNS KSSVEQNAPS 900
IDIALLMQGV SPSNDEYYPT VVIHNLMKIL NDPSLSIHHT AAIQAIMHIF 950
QNLGLRCVSF LDQIIPGIIL VMRSCPPSQL DFYFQQLGSL ISIVKQHIRP 1000
HVEKIYGVIR EFFPIIKLQI TIISVIESIS KALEGEFKRF VPETLTFFLD 1050
ILENDQSNKR IVPIRILKSL VTFGPNLEDY SHLIMPIVVR MTEYSAGSLK 1100
KISIITLGRL AKNINLSEMS SRIVQALVRI LNNGDRELTK ATMNTLSLLL 1150
LQLGTDFVVF VPVINKALLR NRIQHSVYDQ LVNKLLNNEC LPTNIIFDKE 1200
NEVPERKNYE DEMQVTKLPV NQNILKNAWY CSQQKTKEDW QEWIRRLSIQ 1250
LLKESPSACL RSCSSLVSVY YPLARELFNA SFSSCWVELQ TSYQEDLIQA 1300
LCKALSSSEN PPEIYQMLLN LVEFMEHDDK PLPIPIHTLG KYAQKCHAFA 1350
KALHYKEVEF LEEPKNSTIE ALISINNQLH QTDSAIGILK HAQQHNELQL 1400
KETWYEKLQR WEDALAAYNE KEAAGEDSVE VMMGKLRSLY ALGEWEELSK 1450
LASEKWGTAK PEVKKAMAPL AAGAAWGLEQ WDEIAQYTSV MKSQSPDKEF 1500
YDAILCLHRN NFKKAEVHIF NARDLLVTEL SALVNESYNR AYNVVVRAQI 1550
IAELEEIIKY KKLPQNSDKR LTMRETWNTR LLGCQKNIDV WQRILRVRSL 1600
VIKPKEDAQV RIKFANLCRK SGRMALAKKV LNTLLEETDD PDHPNTAKAS 1650
PPVVYAQLKY LWATGLQDEA LKQLINFTSR MAHDLGLDPN NMIAQSVPQQ 1700
SKRVPRHVED YTKLLARCFL KQGEWRVCLQ PKWRLSNPDS ILGSYLLATH 1750
FDNTWYKAWH NWALANFEVI SMLTSVSKKK QEGSDASSVT DINEFDNGMI 1800
GVNTFDAKEV HYSSNLIHRH VIPAIKGFFH SISLSESSSL QDALRLLTLW 1850
FTFGGIPEAT QAMHEGFNLI QIGTWLEVLP QLISRIHQPN QIVSRSLLSL 1900
LSDLGKAHPQ ALVYPLMVAI KSESLSRQKA ALSIIEKMRI HSPVLVDQAE 1950
LVSHELIRMA VLWHEQWYEG LDDASRQFFG EHNTEKMFAA LEPLYEMLKR 2000
GPETLREISF QNSFGRDLND AYEWLMNYKK SKDVSNLNQA WDIYYNVFRK 2050
IGKQLPQLQT LELQHVSPKL LSAHDLELAV PGTRASGGKP IVKISKFEPV 2100
FSVISSKQRP RKFCIKGSDG KDYKYVLKGH EDIRQDSLVM QLFGLVNTLL 2150
QNDAECFRRH LDIQQYPAIP LSPKSGLLGW VPNSDTFHVL IREHREAKKI 2200
PLNIEHWVML QMAPDYDNLT LLQKVEVFTY ALNNTEGQDL YKVLWLKSRS 2250
SETWLERRTT YTRSLAVMSM TGYILGLGDR HPSNLMLDRI TGKVIHIDFG 2300
DCFEAAILRE KFPEKVPFRL TRMLTYAMEV SGIEGSFRIT CENVMKVLRD 2350
NKGSLMAILE AFAFDPLINW GFDLPTKKIE EETGIQLPVM NANELLSNGA 2400
ITEEEVQRVE NEHKNAIRNA RAMLVLKRIT DKLTGNDIRR FNDLDVPEQV 2450
DKLIQQATSV ENLCQHYIGW CPFW 2474
Length:2,474
Mass (Da):281,568
Last modified:January 9, 2007 - v3
Checksum:iF2349690146058CF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1473 – 14731Missing in CAA82048. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71416 Genomic DNA. Translation: CAA50548.1.
Z28203 Genomic DNA. Translation: CAA82048.1.
BK006944 Genomic DNA. Translation: DAA08966.1.
PIRiS38040.
RefSeqiNP_012719.2. NM_001179768.1.

Genome annotation databases

EnsemblFungiiYKL203C; YKL203C; YKL203C.
GeneIDi853632.
KEGGisce:YKL203C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71416 Genomic DNA. Translation: CAA50548.1 .
Z28203 Genomic DNA. Translation: CAA82048.1 .
BK006944 Genomic DNA. Translation: DAA08966.1 .
PIRi S38040.
RefSeqi NP_012719.2. NM_001179768.1.

3D structure databases

ProteinModelPortali P32600.
SMRi P32600. Positions 1405-1447, 1955-2420, 2442-2474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33920. 250 interactions.
DIPi DIP-2332N.
IntActi P32600. 24 interactions.
MINTi MINT-2843476.
STRINGi 4932.YKL203C.

Proteomic databases

MaxQBi P32600.
PaxDbi P32600.
PeptideAtlasi P32600.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL203C ; YKL203C ; YKL203C .
GeneIDi 853632.
KEGGi sce:YKL203C.

Organism-specific databases

CYGDi YKL203c.
SGDi S000001686. TOR2.

Phylogenomic databases

eggNOGi COG5032.
GeneTreei ENSGT00720000108744.
HOGENOMi HOG000163215.
KOi K07203.
OMAi TYKQNIG.
OrthoDBi EOG7Z3FCR.

Enzyme and pathway databases

BioCyci YEAST:G3O-31962-MONOMER.
BRENDAi 2.7.1.137. 984.
Reactomei REACT_188481. S6K1-mediated signalling.
REACT_188925. CD28 dependent PI3K/Akt signaling.
REACT_188931. PIP3 activates AKT signaling.
REACT_219346. HSF1-dependent transactivation.
REACT_223756. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 974511.
PROi P32600.

Gene expression databases

Genevestigatori P32600.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view ]
Pfami PF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 9 hits.
SSF56112. SSF56112. 3 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression."
    Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N., Hall M.N.
    Cell 73:585-596(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JK9-3D.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin."
    Zheng X.-F., Florentino D., Chen J., Crabtree G.R., Schreiber S.L.
    Cell 82:121-130(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity."
    Cardenas M.E., Heitman J.
    EMBO J. 14:5892-5907(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-1975 AND ASP-2279, CATALYTIC ACTIVITY.
  6. "TOR controls translation initiation and early G1 progression in yeast."
    Barbet N.C., Schneider U., Helliwell S.B., Stansfield I., Tuite M.F., Hall M.N.
    Mol. Biol. Cell 7:25-42(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "TOR2 is required for organization of the actin cytoskeleton in yeast."
    Schmidt A., Kunz J., Hall M.N.
    Proc. Natl. Acad. Sci. U.S.A. 93:13780-13785(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease."
    Schmidt A., Beck T., Koller A., Kunz J., Hall M.N.
    EMBO J. 17:6924-6931(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae."
    Berset C., Trachsel H., Altmann M.
    Proc. Natl. Acad. Sci. U.S.A. 95:4264-4269(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast."
    Jiang Y., Broach J.R.
    EMBO J. 18:2782-2792(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae."
    Powers T., Walter P.
    Mol. Biol. Cell 10:987-1000(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors."
    Beck T., Hall M.N.
    Nature 402:689-692(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "HEAT repeats mediate plasma membrane localization of Tor2p in yeast."
    Kunz J., Schneider U., Howald I., Schmidt A., Hall M.N.
    J. Biol. Chem. 275:37011-37020(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway."
    Jacinto E., Guo B., Arndt K.T., Schmelzle T., Hall M.N.
    Mol. Cell 8:1017-1026(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
    Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N.
    Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  16. "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae."
    Wedaman K.P., Reinke A., Anderson S., Yates J.R. III, McCaffery J.M., Powers T.
    Mol. Biol. Cell 14:1204-1220(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH LST8.
  17. "Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway."
    deHart A.K.A., Schnell J.D., Allen D.A., Tsai J.-Y., Hicke L.
    Mol. Biol. Cell 14:4676-4684(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RECEPTOR ENDOCYTOSIS, MUTAGENESIS OF GLY-2129.
  18. "TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1."
    Martin D.E., Soulard A., Hall M.N.
    Cell 119:969-979(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton."
    Audhya A., Loewith R., Parsons A.B., Gao L., Tabuchi M., Zhou H., Boone C., Hall M.N., Emr S.D.
    EMBO J. 23:3747-3757(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION OF SLM1-SLM2.
  20. "Molecular organization of target of rapamycin complex 2."
    Wullschleger S., Loewith R., Oppliger W., Hall M.N.
    J. Biol. Chem. 280:30697-30704(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH LST8 AND TSC11.
  21. "The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2."
    Fadri M., Daquinag A., Wang S., Xue T., Kunz J.
    Mol. Biol. Cell 16:1883-1900(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLM1 AND SLM2.
  22. "Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization."
    Kamada Y., Fujioka Y., Suzuki N.N., Inagaki F., Wullschleger S., Loewith R., Hall M.N., Ohsumi Y.
    Mol. Cell. Biol. 25:7239-7248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION OF YPK2, MUTAGENESIS OF ASP-2298.
  23. "Mutual antagonism of TOR and calcineurin signaling."
    Mulet J.M., Martin D.E., Loewith R., Hall M.N.
    J. Biol. Chem. 281:33000-33007(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLM1.
  24. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOR2_YEAST
AccessioniPrimary (citable) accession number: P32600
Secondary accession number(s): D6VX00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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