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Reviewed, UniProtKB/Swiss-Prot P32599 (FIMB_YEAST)

Last modified November 3, 2009. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fimbrin
Alternative name(s):
    ABP67
Gene names
Name: SAC6
Ordered Locus Names: YDR129C
ORF Names: YD9302.04C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.

Miscellaneous

Present with 3510 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Contains 2 actin-binding domains.

Contains 4 CH (calponin-homology) domains.

Contains 2 EF-hand domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Fimbrin
PRO_0000073757

Regions

Domain125 – 394270Actin-binding 1
Domain139 – 259121CH 1
Domain287 – 390104CH 2
Domain395 – 642248Actin-binding 2
Domain411 – 521111CH 3
Domain534 – 642109CH 4
Calcium binding29 – 40121 By similarity
Calcium binding64 – 75122 By similarity

Amino acid modifications

Modified residue1291Phosphoserine Ref.5
Modified residue4661Phosphoserine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P32599-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 9AF17D056173A690

FASTA64271,773
        10         20         30         40         50         60 
MNIVKLQRKF PILTQEDLFS TIEKFRAIDL DDKGWVEKQQ ALEAVSKDGD ATYDEARETL 

        70         80         90        100        110        120 
KHVGVDASGR VELDDYVGLV AKLRESKTGA APQTTFNVAP NSTPIVSTAA TGLQHKGKGT 

       130        140        150        160        170        180 
QAKIIVAGSQ TGTTHTINEE ERREFTKHIN SVLAGDQDIG DLLPFPTDTF QLFDECRDGL 

       190        200        210        220        230        240 
VLSKLINDSV PDTIDTRVLN WPKKGKELNN FQASENANIV INSAKAIGCV VVNVHSEDII 

       250        260        270        280        290        300 
EGREHLILGL IWQIIRRGLL SKIDIKLHPE LYRLLEDDET LEQFLRLPPE QILLRWFNYH 

       310        320        330        340        350        360 
LKQANWNRRV TNFSKDVSDG ENYTILLNQL DPALCSKAPL QTTDLMERAE QVLQNAEKLD 

       370        380        390        400        410        420 
CRKYLTPSSL VAGNPKLNLA FVAHLFNTHP GLEPIQEEEK PEIEEFDAEG EREARVFTLW 

       430        440        450        460        470        480 
LNSLDVDPPV ISLFDDLKDG LILLQAYEKV MPGAVDFKHV NKRPASGAEI SRFKALENTN 

       490        500        510        520        530        540 
YAVDLGRAKG FSLVGIEGSD IVDGNKLLTL GLVWQLMRRN ISITMKTLSS SGRDMSDSQI 

       550        560        570        580        590        600 
LKWAQDQVTK GGKNSTIRSF KDQALSNAHF LLDVLNGIAP GYVDYDLVTP GNTEEERYAN 

       610        620        630        640 
ARLAISIARK LGALIWLVPE DINEVRARLI ITFIASLMTL NK

« Hide

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References

« Hide 'large scale' references
[1]"Requirement of yeast fimbrin for actin organization and morphogenesis in vivo."
Adams A.E.M., Botstein D., Drubin D.G.
Nature 354:404-408(1991) [PubMed: 1956405] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, MASS SPECTROMETRY.
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X63867 Genomic DNA. Translation: CAA45346.1.
Z48179 Genomic DNA. Translation: CAA88210.1.
PIRS29320.
RefSeqNP_010414.1.

3D structure databases

HSSPHSSP built from PDB template 1AOA based on UniProtKB P13797.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:718N.
IntActP32599. 32 interactions.
STRINGP32599.

Proteomic databases

PeptideAtlasP32599.
PRIDEP32599.

Genome annotation databases

EnsemblYDR129C; YDR129C; YDR129C; Saccharomyces cerevisiae. [Genome view]
GeneID851707.
GenomeReviewsGene locus YDR129C in contig Z71256_GR.
KEGGsce:YDR129C.
NMPDRfig|4932.3.peg.1163.

Organism-specific databases

CYGDYDR129c.
SGDS000002536. SAC6.

Phylogenomic databases

HOGENOMP32599.
OMATHTINEE.

Gene expression databases

ArrayExpressP32599.
GenevestigatorP32599.
GermOnlineYDR129C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. Calponin_act_bd.
IPR011992. EF-Hand_type.
[Graphical view]
Gene3DG3DSA:1.10.418.10. Calponin-homology. 4 hits.
G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PfamPF00307. CH. 4 hits.
[Graphical view]
SMARTSM00033. CH. 4 hits.
[Graphical view]
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio969392.

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Entry information

Entry nameFIMB_YEAST
AccessionPrimary (citable) accession number: P32599
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 3, 2009
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents