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Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Moloney murine sarcoma virus (strain ts110) (MoMSV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ATPPROSITE-ProRule annotation1
Active sitei209Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 88ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMoloney murine sarcoma virus (strain ts110) (MoMSV)
Taxonomic identifieri31691 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863621 – 354Serine/threonine-protein kinase-transforming protein mosAdd BLAST354

Structurei

3D structure databases

ProteinModelPortaliP32593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 350Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VSHVTVPSEG VMPSPLSLCR YLPRELSPSV DSRSCSIPLV APRKAGKLFL
60 70 80 90 100
GTTPPRAPGL PRRLAWFSID WEQVCLMHRL GSGGFGSVYK ATYHGVPVAI
110 120 130 140 150
KQVNKCTEDL RASQRSFWAE LNIAGLRHDN IVRVVAASTR TPEDSNSLGT
160 170 180 190 200
IIMEFGGNVT LHQVIYDATR SPEPLSCRKQ LSLGKCLKYS LDVVNGLLFL
210 220 230 240 250
HSQSILHLDL KPANILISEQ DVCKISDFGC SQKLQVLRGR QASPPHIGGT
260 270 280 290 300
YTHQAPEILK GEIATPKADI YSFGITLWQM TTREVPYSGE PQYVQYAVVA
310 320 330 340 350
YNLRPSLAGA VFTASLTGKA LQNIIQSCWE ARGLQRPSAE LLQRDLKAFR

GTLG
Length:354
Mass (Da):38,851
Last modified:October 1, 1993 - v1
Checksum:i95F845823B748965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96854 Genomic DNA. No translation available.
PIRiB42745. TVMVMU.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96854 Genomic DNA. No translation available.
PIRiB42745. TVMVMU.

3D structure databases

ProteinModelPortaliP32593.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOS_MSVMT
AccessioniPrimary (citable) accession number: P32593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is probably translated as a Gag-Mos polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.