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Protein

Heat shock protein homolog SSE2

Gene

SSE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a calcium-dependent calmodulin-binding activity.

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • protein folding Source: SGD
  • protein refolding Source: SGD
  • regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29117-MONOMER.
ReactomeiR-SCE-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein homolog SSE2
Gene namesi
Name:SSE2
Synonyms:HSP
Ordered Locus Names:YBR169C
ORF Names:YBR1221
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR169C.
SGDiS000000373. SSE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Heat shock protein homolog SSE2PRO_0000078397Add
BLAST

Proteomic databases

MaxQBiP32590.
PeptideAtlasiP32590.
PRIDEiP32590.

2D gel databases

UCD-2DPAGEP32590.

PTM databases

iPTMnetiP32590.

Expressioni

Inductioni

By upshift to 37 degrees Celsius.

Interactioni

Protein-protein interaction databases

BioGridi32869. 54 interactions.
DIPiDIP-4862N.
IntActiP32590. 10 interactions.
MINTiMINT-500770.

Structurei

3D structure databases

ProteinModelPortaliP32590.
SMRiP32590. Positions 1-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

GeneTreeiENSGT00780000122466.
HOGENOMiHOG000228138.
InParanoidiP32590.
KOiK09485.
OMAiESKIGRY.
OrthoDBiEOG7B8SC7.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG
60 70 80 90 100
ESGKTKQTSN VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV
110 120 130 140 150
GVEVEFGGKT HVFSATQLTA MFIDKVKHTV QEETKSSITD VCLAVPVWYS
160 170 180 190 200
EEQRYNIADA ARIAGLNPVR IVNDVTAAAV SYGVFKNDLP GPEEKPRIIG
210 220 230 240 250
LVDIGHSTYT CSIMAFRKGE MKVLGTAYDK HFGGRDFDRA ITEHFADQFK
260 270 280 290 300
DKYKIDIRKN PKAYNRILIA AEKLKKVLSA NTTAPFSVES VMDDIDVSSQ
310 320 330 340 350
LSREELEELV EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL
360 370 380 390 400
KKSISDVFGK PLSSTLNQDE AVAKGAAFIC AIHSPTLRVR PFKFEDIDPY
410 420 430 440 450
SVSYTWDKQV DDEDRLEVFP ANSSYPSTKL ITLHRTGDFS MKAVYTHPSK
460 470 480 490 500
LPKGTSTTIA KWSFTGVKVP KDQDFIPVKV KLRCDPSGLH IIENAYTTED
510 520 530 540 550
ITVQEPVPLP EDAPEDAEPQ FKEVTKTIKK DVLGMTAKTF ALNPVELNDL
560 570 580 590 600
IEKENELRNQ DKLVAETEDR KNALEEYIYT LRAKLDDEYS DFASDAEKEK
610 620 630 640 650
LKNMLATTEN WLYGDGDDST KAKYIAKYEE LASLGNIIRG RYLAKEEEKR
660 670 680 690
QALRANQETS KMNDIAEKLA EQRRARAASD DSDDNNDENM DLD
Length:693
Mass (Da):77,621
Last modified:January 23, 2007 - v3
Checksum:iD6BC9656D93895C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1678Missing in CAA51027 (PubMed:8257794).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38369 mRNA. Translation: BAA07450.1.
D38371 Genomic DNA. Translation: BAA07452.1.
X72224 Genomic DNA. Translation: CAA51027.1.
Z36038 Genomic DNA. Translation: CAA85130.1.
AY692880 Genomic DNA. Translation: AAT92899.1.
BK006936 Genomic DNA. Translation: DAA07285.1.
PIRiJN0843.
RefSeqiNP_009728.1. NM_001178517.1.

Genome annotation databases

EnsemblFungiiYBR169C; YBR169C; YBR169C.
GeneIDi852467.
KEGGisce:YBR169C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38369 mRNA. Translation: BAA07450.1.
D38371 Genomic DNA. Translation: BAA07452.1.
X72224 Genomic DNA. Translation: CAA51027.1.
Z36038 Genomic DNA. Translation: CAA85130.1.
AY692880 Genomic DNA. Translation: AAT92899.1.
BK006936 Genomic DNA. Translation: DAA07285.1.
PIRiJN0843.
RefSeqiNP_009728.1. NM_001178517.1.

3D structure databases

ProteinModelPortaliP32590.
SMRiP32590. Positions 1-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32869. 54 interactions.
DIPiDIP-4862N.
IntActiP32590. 10 interactions.
MINTiMINT-500770.

PTM databases

iPTMnetiP32590.

2D gel databases

UCD-2DPAGEP32590.

Proteomic databases

MaxQBiP32590.
PeptideAtlasiP32590.
PRIDEiP32590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR169C; YBR169C; YBR169C.
GeneIDi852467.
KEGGisce:YBR169C.

Organism-specific databases

EuPathDBiFungiDB:YBR169C.
SGDiS000000373. SSE2.

Phylogenomic databases

GeneTreeiENSGT00780000122466.
HOGENOMiHOG000228138.
InParanoidiP32590.
KOiK09485.
OMAiESKIGRY.
OrthoDBiEOG7B8SC7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29117-MONOMER.
ReactomeiR-SCE-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

NextBioi971417.
PROiP32590.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of SSE1 and SSE2, new members of the yeast HSP70 multigene family."
    Mukai H., Kuno T., Tanaka H., Hirata D., Miyakawa T., Tanaka C.
    Gene 132:57-66(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 204626 / S288c / A364A.
  2. "Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus."
    Kurihara T., Silver P.A.
    Mol. Biol. Cell 4:919-930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHSP79_YEAST
AccessioniPrimary (citable) accession number: P32590
Secondary accession number(s): D6VQG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.