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Protein

Heat shock protein homolog SSE1

Gene

SSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: SGD
  • ATP binding Source: SGD
  • peptide binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • protein refolding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34008-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein homolog SSE1
Alternative name(s):
Chaperone protein MSI3
Gene namesi
Name:SSE1
Synonyms:MSI3
Ordered Locus Names:YPL106C
ORF Names:LPG3C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL106C.
SGDiS000006027. SSE1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • polysome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000783962 – 693Heat shock protein homolog SSE1Add BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei242PhosphothreonineCombined sources1
Modified residuei660PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP32589.
PRIDEiP32589.

2D gel databases

SWISS-2DPAGEP32589.

PTM databases

iPTMnetiP32589.

Expressioni

Inductioni

Increases a few-fold upon upshift to 37 degrees Celsius.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028293EBI-8648,EBI-8659
HSPA1BP081072EBI-8648,EBI-629985From a different organism.
SSA1P105918EBI-8648,EBI-8591
SSB1P114842EBI-8648,EBI-8627

Protein-protein interaction databases

BioGridi36075. 261 interactors.
DIPiDIP-6645N.
IntActiP32589. 126 interactors.
MINTiMINT-8285491.

Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi11 – 20Combined sources10
Beta strandi23 – 27Combined sources5
Beta strandi34 – 37Combined sources4
Beta strandi40 – 42Combined sources3
Beta strandi44 – 49Combined sources6
Helixi51 – 57Combined sources7
Helixi61 – 63Combined sources3
Helixi68 – 71Combined sources4
Helixi81 – 85Combined sources5
Beta strandi90 – 94Combined sources5
Beta strandi98 – 106Combined sources9
Beta strandi109 – 114Combined sources6
Helixi115 – 134Combined sources20
Beta strandi140 – 145Combined sources6
Helixi151 – 163Combined sources13
Beta strandi167 – 173Combined sources7
Helixi174 – 185Combined sources12
Beta strandi192 – 194Combined sources3
Beta strandi197 – 204Combined sources8
Beta strandi209 – 217Combined sources9
Beta strandi220 – 229Combined sources10
Helixi234 – 252Combined sources19
Helixi257 – 259Combined sources3
Helixi261 – 280Combined sources20
Beta strandi282 – 288Combined sources7
Beta strandi291 – 294Combined sources4
Beta strandi297 – 302Combined sources6
Helixi303 – 309Combined sources7
Helixi311 – 314Combined sources4
Turni315 – 318Combined sources4
Helixi319 – 328Combined sources10
Helixi332 – 334Combined sources3
Beta strandi337 – 342Combined sources6
Helixi343 – 346Combined sources4
Helixi348 – 358Combined sources11
Turni368 – 370Combined sources3
Helixi371 – 382Combined sources12
Beta strandi385 – 387Combined sources3
Beta strandi393 – 398Combined sources6
Beta strandi402 – 406Combined sources5
Beta strandi414 – 419Combined sources6
Beta strandi423 – 437Combined sources15
Beta strandi439 – 446Combined sources8
Helixi448 – 450Combined sources3
Beta strandi457 – 465Combined sources9
Beta strandi476 – 484Combined sources9
Beta strandi490 – 498Combined sources9
Beta strandi505 – 507Combined sources3
Beta strandi520 – 522Combined sources3
Beta strandi529 – 532Combined sources4
Beta strandi534 – 538Combined sources5
Helixi544 – 585Combined sources42
Turni586 – 589Combined sources4
Helixi590 – 592Combined sources3
Helixi595 – 611Combined sources17
Turni612 – 614Combined sources3
Helixi615 – 618Combined sources4
Helixi621 – 653Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QXLX-ray2.41A/B2-659[»]
3C7NX-ray3.12A1-666[»]
3D2EX-ray2.35A/C1-502[»]
A/C525-693[»]
3D2FX-ray2.30A/C1-502[»]
A/C525-693[»]
ProteinModelPortaliP32589.
SMRiP32589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32589.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000129925.
HOGENOMiHOG000228138.
InParanoidiP32589.
KOiK09485.
OMAiYTMNADE.
OrthoDBiEOG092C17NN.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPFGLDLG NNNSVLAVAR NRGIDIVVNE VSNRSTPSVV GFGPKNRYLG
60 70 80 90 100
ETGKNKQTSN IKNTVANLKR IIGLDYHHPD FEQESKHFTS KLVELDDKKT
110 120 130 140 150
GAEVRFAGEK HVFSATQLAA MFIDKVKDTV KQDTKANITD VCIAVPPWYT
160 170 180 190 200
EEQRYNIADA ARIAGLNPVR IVNDVTAAGV SYGIFKTDLP EGEEKPRIVA
210 220 230 240 250
FVDIGHSSYT CSIMAFKKGQ LKVLGTACDK HFGGRDFDLA ITEHFADEFK
260 270 280 290 300
TKYKIDIREN PKAYNRILTA AEKLKKVLSA NTNAPFSVES VMNDVDVSSQ
310 320 330 340 350
LSREELEELV KPLLERVTEP VTKALAQAKL SAEEVDFVEI IGGTTRIPTL
360 370 380 390 400
KQSISEAFGK PLSTTLNQDE AIAKGAAFIC AIHSPTLRVR PFKFEDIHPY
410 420 430 440 450
SVSYSWDKQV EDEDHMEVFP AGSSFPSTKL ITLNRTGDFS MAASYTDITQ
460 470 480 490 500
LPPNTPEQIA NWEITGVQLP EGQDSVPVKL KLRCDPSGLH TIEEAYTIED
510 520 530 540 550
IEVEEPIPLP EDAPEDAEQE FKKVTKTVKK DDLTIVAHTF GLDAKKLNEL
560 570 580 590 600
IEKENEMLAQ DKLVAETEDR KNTLEEYIYT LRGKLEEEYA PFASDAEKTK
610 620 630 640 650
LQGMLNKAEE WLYDEGFDSI KAKYIAKYEE LASLGNIIRG RYLAKEEEKK
660 670 680 690
QAIRSKQEAS QMAAMAEKLA AQRKAEAEKK EEKKDTEGDV DMD
Length:693
Mass (Da):77,366
Last modified:January 23, 2007 - v4
Checksum:i6558259111B0BC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269 – 270TA → NT in BAA02576 (PubMed:8406043).Curated2
Sequence conflicti269 – 270TA → NT in BAA07449 (PubMed:8406043).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13319 mRNA. Translation: BAA02576.1.
D38368 mRNA. Translation: BAA07449.1.
D38370 Genomic DNA. Translation: BAA07451.1.
D13743 Genomic DNA. Translation: BAA02888.1.
U43281 Genomic DNA. Translation: AAB68194.1.
BK006949 Genomic DNA. Translation: DAA11327.1.
PIRiS46417.
RefSeqiNP_015219.1. NM_001183920.1.

Genome annotation databases

EnsemblFungiiYPL106C; YPL106C; YPL106C.
GeneIDi855998.
KEGGisce:YPL106C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13319 mRNA. Translation: BAA02576.1.
D38368 mRNA. Translation: BAA07449.1.
D38370 Genomic DNA. Translation: BAA07451.1.
D13743 Genomic DNA. Translation: BAA02888.1.
U43281 Genomic DNA. Translation: AAB68194.1.
BK006949 Genomic DNA. Translation: DAA11327.1.
PIRiS46417.
RefSeqiNP_015219.1. NM_001183920.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QXLX-ray2.41A/B2-659[»]
3C7NX-ray3.12A1-666[»]
3D2EX-ray2.35A/C1-502[»]
A/C525-693[»]
3D2FX-ray2.30A/C1-502[»]
A/C525-693[»]
ProteinModelPortaliP32589.
SMRiP32589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36075. 261 interactors.
DIPiDIP-6645N.
IntActiP32589. 126 interactors.
MINTiMINT-8285491.

PTM databases

iPTMnetiP32589.

2D gel databases

SWISS-2DPAGEP32589.

Proteomic databases

MaxQBiP32589.
PRIDEiP32589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL106C; YPL106C; YPL106C.
GeneIDi855998.
KEGGisce:YPL106C.

Organism-specific databases

EuPathDBiFungiDB:YPL106C.
SGDiS000006027. SSE1.

Phylogenomic databases

GeneTreeiENSGT00840000129925.
HOGENOMiHOG000228138.
InParanoidiP32589.
KOiK09485.
OMAiYTMNADE.
OrthoDBiEOG092C17NN.

Enzyme and pathway databases

BioCyciYEAST:G3O-34008-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP32589.
PROiP32589.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7F_YEAST
AccessioniPrimary (citable) accession number: P32589
Secondary accession number(s): D6W3R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 167 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 71700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.