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Protein

Heat shock protein homolog SSE1

Gene

SSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.

Miscellaneous

Present with 71700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: SGD
  • ATP binding Source: SGD
  • calmodulin binding Source: UniProtKB-KW
  • peptide binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • protein refolding Source: SGD

Keywordsi

Molecular functionCalmodulin-binding, Chaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34008-MONOMER
ReactomeiR-SCE-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein homolog SSE1
Alternative name(s):
Chaperone protein MSI3
Gene namesi
Name:SSE1
Synonyms:MSI3
Ordered Locus Names:YPL106C
ORF Names:LPG3C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL106C
SGDiS000006027 SSE1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000783962 – 693Heat shock protein homolog SSE1Add BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei242PhosphothreonineCombined sources1
Modified residuei660PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP32589
PaxDbiP32589
PRIDEiP32589

2D gel databases

SWISS-2DPAGEP32589

PTM databases

CarbonylDBiP32589
iPTMnetiP32589

Expressioni

Inductioni

Increases a few-fold upon upshift to 37 degrees Celsius.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36075, 599 interactors
DIPiDIP-6645N
IntActiP32589, 127 interactors
MINTiP32589
STRINGi4932.YPL106C

Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi11 – 20Combined sources10
Beta strandi23 – 27Combined sources5
Beta strandi34 – 37Combined sources4
Beta strandi40 – 42Combined sources3
Beta strandi44 – 49Combined sources6
Helixi51 – 57Combined sources7
Helixi61 – 63Combined sources3
Helixi68 – 71Combined sources4
Helixi81 – 85Combined sources5
Beta strandi90 – 94Combined sources5
Beta strandi98 – 106Combined sources9
Beta strandi109 – 114Combined sources6
Helixi115 – 134Combined sources20
Beta strandi140 – 145Combined sources6
Helixi151 – 163Combined sources13
Beta strandi167 – 173Combined sources7
Helixi174 – 185Combined sources12
Beta strandi192 – 194Combined sources3
Beta strandi197 – 204Combined sources8
Beta strandi209 – 217Combined sources9
Beta strandi220 – 229Combined sources10
Helixi234 – 252Combined sources19
Helixi257 – 259Combined sources3
Helixi261 – 274Combined sources14
Beta strandi282 – 292Combined sources11
Beta strandi295 – 302Combined sources8
Helixi303 – 309Combined sources7
Helixi311 – 314Combined sources4
Helixi319 – 324Combined sources6
Beta strandi326 – 332Combined sources7
Beta strandi335 – 337Combined sources3
Beta strandi340 – 345Combined sources6
Helixi346 – 350Combined sources5
Helixi352 – 355Combined sources4
Turni356 – 359Combined sources4
Helixi360 – 365Combined sources6
Turni368 – 370Combined sources3
Helixi373 – 375Combined sources3
Beta strandi378 – 383Combined sources6
Helixi386 – 388Combined sources3
Helixi390 – 393Combined sources4
Helixi401 – 406Combined sources6
Turni415 – 417Combined sources3
Helixi418 – 429Combined sources12
Beta strandi445 – 449Combined sources5
Beta strandi451 – 455Combined sources5
Beta strandi463 – 467Combined sources5
Beta strandi475 – 488Combined sources14
Beta strandi490 – 497Combined sources8
Beta strandi505 – 507Combined sources3
Beta strandi515 – 522Combined sources8
Beta strandi529 – 532Combined sources4
Beta strandi536 – 542Combined sources7
Beta strandi549 – 556Combined sources8
Beta strandi569 – 577Combined sources9
Helixi582 – 589Combined sources8
Helixi590 – 592Combined sources3
Helixi593 – 613Combined sources21
Turni614 – 616Combined sources3
Helixi618 – 630Combined sources13
Turni631 – 633Combined sources3
Helixi639 – 664Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QXLX-ray2.41A/B2-659[»]
3C7NX-ray3.12A1-666[»]
3D2EX-ray2.35A/C1-502[»]
A/C525-693[»]
3D2FX-ray2.30A/C1-502[»]
A/C525-693[»]
ProteinModelPortaliP32589
SMRiP32589
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32589

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016919
HOGENOMiHOG000228138
InParanoidiP32589
KOiK09485
OMAiMNDMTAV
OrthoDBiEOG092C17NN

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 2 hits
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPFGLDLG NNNSVLAVAR NRGIDIVVNE VSNRSTPSVV GFGPKNRYLG
60 70 80 90 100
ETGKNKQTSN IKNTVANLKR IIGLDYHHPD FEQESKHFTS KLVELDDKKT
110 120 130 140 150
GAEVRFAGEK HVFSATQLAA MFIDKVKDTV KQDTKANITD VCIAVPPWYT
160 170 180 190 200
EEQRYNIADA ARIAGLNPVR IVNDVTAAGV SYGIFKTDLP EGEEKPRIVA
210 220 230 240 250
FVDIGHSSYT CSIMAFKKGQ LKVLGTACDK HFGGRDFDLA ITEHFADEFK
260 270 280 290 300
TKYKIDIREN PKAYNRILTA AEKLKKVLSA NTNAPFSVES VMNDVDVSSQ
310 320 330 340 350
LSREELEELV KPLLERVTEP VTKALAQAKL SAEEVDFVEI IGGTTRIPTL
360 370 380 390 400
KQSISEAFGK PLSTTLNQDE AIAKGAAFIC AIHSPTLRVR PFKFEDIHPY
410 420 430 440 450
SVSYSWDKQV EDEDHMEVFP AGSSFPSTKL ITLNRTGDFS MAASYTDITQ
460 470 480 490 500
LPPNTPEQIA NWEITGVQLP EGQDSVPVKL KLRCDPSGLH TIEEAYTIED
510 520 530 540 550
IEVEEPIPLP EDAPEDAEQE FKKVTKTVKK DDLTIVAHTF GLDAKKLNEL
560 570 580 590 600
IEKENEMLAQ DKLVAETEDR KNTLEEYIYT LRGKLEEEYA PFASDAEKTK
610 620 630 640 650
LQGMLNKAEE WLYDEGFDSI KAKYIAKYEE LASLGNIIRG RYLAKEEEKK
660 670 680 690
QAIRSKQEAS QMAAMAEKLA AQRKAEAEKK EEKKDTEGDV DMD
Length:693
Mass (Da):77,366
Last modified:January 23, 2007 - v4
Checksum:i6558259111B0BC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269 – 270TA → NT in BAA02576 (PubMed:8406043).Curated2
Sequence conflicti269 – 270TA → NT in BAA07449 (PubMed:8406043).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13319 mRNA Translation: BAA02576.1
D38368 mRNA Translation: BAA07449.1
D38370 Genomic DNA Translation: BAA07451.1
D13743 Genomic DNA Translation: BAA02888.1
U43281 Genomic DNA Translation: AAB68194.1
BK006949 Genomic DNA Translation: DAA11327.1
PIRiS46417
RefSeqiNP_015219.1, NM_001183920.1

Genome annotation databases

EnsemblFungiiYPL106C; YPL106C; YPL106C
GeneIDi855998
KEGGisce:YPL106C

Similar proteinsi

Entry informationi

Entry nameiHSP7F_YEAST
AccessioniPrimary (citable) accession number: P32589
Secondary accession number(s): D6W3R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 181 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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