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P32587

- PYP3_SCHPO

UniProt

P32587 - PYP3_SCHPO

Protein

Tyrosine-protein phosphatase 3

Gene

pyp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    • Comment

    Functioni

    Contributes to dephosphorylation of tyrosine 15 of cdc2.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei227 – 2271Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: PomBase

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. peptidyl-tyrosine dephosphorylation Source: GOC
    3. positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
    4. protein dephosphorylation Source: PomBase
    5. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 3
    Short name:
    PTPase 3
    Gene namesi
    Name:pyp3
    ORF Names:SPAC11E3.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC11E3.09.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Tyrosine-protein phosphatase 3PRO_0000094860Add
    BLAST

    Proteomic databases

    MaxQBiP32587.

    Interactioni

    Protein-protein interaction databases

    BioGridi277948. 8 interactions.
    MINTiMINT-4688440.
    STRINGi4896.SPAC11E3.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP32587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 292269Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    KOiK01104.
    OMAiNANQELQ.
    OrthoDBiEOG7R573B.
    PhylomeDBiP32587.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32587-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFKEVSTEN GVLTPLITIK EKAYMIIEGL NEEEIELLNT RLPKLSKKAL    50
    ARNRYSNIVP YENTRVRLDP MWKEACDYIN ASIVKIPSGK TFIATQGPTS 100
    NSIDVFWKMV WQSVPKSGII VMLTKLRERH RLKCDIYWPV ELFETLNIGD 150
    LSVILVKVYT LTSLNEVQVR EFELNKDGVK KKILHFYYNG WPDFGAPHTF 200
    SLLSLTRYIK SLSYSPDFET APIIVHCSAG CGRTGTFMAL FEILSQTDDS 250
    TSTSKFEVDN IANIVSSLRS QRMQSVQSVD QLVFLYTVSQ ELLQGKEFLL 300
    PQL 303
    Length:303
    Mass (Da):34,583
    Last modified:October 1, 1993 - v1
    Checksum:i6ED642C818B32791
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69994 Genomic DNA. Translation: CAA49609.1.
    CU329670 Genomic DNA. Translation: CAB11188.1.
    PIRiS28392.
    RefSeqiNP_594934.1. NM_001020365.2.

    Genome annotation databases

    EnsemblFungiiSPAC11E3.09.1; SPAC11E3.09.1:pep; SPAC11E3.09.
    GeneIDi2541443.
    KEGGispo:SPAC11E3.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69994 Genomic DNA. Translation: CAA49609.1 .
    CU329670 Genomic DNA. Translation: CAB11188.1 .
    PIRi S28392.
    RefSeqi NP_594934.1. NM_001020365.2.

    3D structure databases

    ProteinModelPortali P32587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277948. 8 interactions.
    MINTi MINT-4688440.
    STRINGi 4896.SPAC11E3.09-1.

    Proteomic databases

    MaxQBi P32587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC11E3.09.1 ; SPAC11E3.09.1:pep ; SPAC11E3.09 .
    GeneIDi 2541443.
    KEGGi spo:SPAC11E3.09.

    Organism-specific databases

    PomBasei SPAC11E3.09.

    Phylogenomic databases

    eggNOGi COG5599.
    KOi K01104.
    OMAi NANQELQ.
    OrthoDBi EOG7R573B.
    PhylomeDBi P32587.

    Miscellaneous databases

    NextBioi 20802545.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pyp3 PTPase acts as a mitotic inducer in fission yeast."
      Millar J.B.A., Lenaers G., Russell P.
      EMBO J. 11:4933-4941(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPYP3_SCHPO
    AccessioniPrimary (citable) accession number: P32587
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3