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Protein

Tyrosine-protein phosphatase 3

Gene

pyp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Contributes to dephosphorylation of tyrosine 15 of cdc2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • signal transduction Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 3
Short name:
PTPase 3
Gene namesi
Name:pyp3
ORF Names:SPAC11E3.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC11E3.09
PomBaseiSPAC11E3.09 pyp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948601 – 303Tyrosine-protein phosphatase 3Add BLAST303

Proteomic databases

MaxQBiP32587
PaxDbiP32587
PRIDEiP32587

Interactioni

Protein-protein interaction databases

BioGridi277948, 8 interactors
STRINGi4896.SPAC11E3.09.1

Structurei

3D structure databases

ProteinModelPortaliP32587
SMRiP32587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 292Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Phylogenomic databases

InParanoidiP32587
KOiK18035
OMAiTFRSQRI
OrthoDBiEOG092C26OL
PhylomeDBiP32587

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P32587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKEVSTEN GVLTPLITIK EKAYMIIEGL NEEEIELLNT RLPKLSKKAL
60 70 80 90 100
ARNRYSNIVP YENTRVRLDP MWKEACDYIN ASIVKIPSGK TFIATQGPTS
110 120 130 140 150
NSIDVFWKMV WQSVPKSGII VMLTKLRERH RLKCDIYWPV ELFETLNIGD
160 170 180 190 200
LSVILVKVYT LTSLNEVQVR EFELNKDGVK KKILHFYYNG WPDFGAPHTF
210 220 230 240 250
SLLSLTRYIK SLSYSPDFET APIIVHCSAG CGRTGTFMAL FEILSQTDDS
260 270 280 290 300
TSTSKFEVDN IANIVSSLRS QRMQSVQSVD QLVFLYTVSQ ELLQGKEFLL

PQL
Length:303
Mass (Da):34,583
Last modified:October 1, 1993 - v1
Checksum:i6ED642C818B32791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69994 Genomic DNA Translation: CAA49609.1
CU329670 Genomic DNA Translation: CAB11188.1
PIRiS28392
RefSeqiNP_594934.1, NM_001020365.2

Genome annotation databases

EnsemblFungiiSPAC11E3.09.1; SPAC11E3.09.1:pep; SPAC11E3.09
GeneIDi2541443
KEGGispo:SPAC11E3.09

Entry informationi

Entry nameiPYP3_SCHPO
AccessioniPrimary (citable) accession number: P32587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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