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P32587

- PYP3_SCHPO

UniProt

P32587 - PYP3_SCHPO

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Protein
Tyrosine-protein phosphatase 3
Gene
pyp3, SPAC11E3.09
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Contributes to dephosphorylation of tyrosine 15 of cdc2.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
  4. protein dephosphorylation Source: PomBase
  5. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 3
Short name:
PTPase 3
Gene namesi
Name:pyp3
ORF Names:SPAC11E3.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC11E3.09.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Tyrosine-protein phosphatase 3
PRO_0000094860Add
BLAST

Proteomic databases

MaxQBiP32587.

Interactioni

Protein-protein interaction databases

BioGridi277948. 8 interactions.
MINTiMINT-4688440.
STRINGi4896.SPAC11E3.09-1.

Structurei

3D structure databases

ProteinModelPortaliP32587.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 292269Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5599.
KOiK01104.
OMAiNANQELQ.
OrthoDBiEOG7R573B.
PhylomeDBiP32587.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32587-1 [UniParc]FASTAAdd to Basket

« Hide

MSFKEVSTEN GVLTPLITIK EKAYMIIEGL NEEEIELLNT RLPKLSKKAL    50
ARNRYSNIVP YENTRVRLDP MWKEACDYIN ASIVKIPSGK TFIATQGPTS 100
NSIDVFWKMV WQSVPKSGII VMLTKLRERH RLKCDIYWPV ELFETLNIGD 150
LSVILVKVYT LTSLNEVQVR EFELNKDGVK KKILHFYYNG WPDFGAPHTF 200
SLLSLTRYIK SLSYSPDFET APIIVHCSAG CGRTGTFMAL FEILSQTDDS 250
TSTSKFEVDN IANIVSSLRS QRMQSVQSVD QLVFLYTVSQ ELLQGKEFLL 300
PQL 303
Length:303
Mass (Da):34,583
Last modified:October 1, 1993 - v1
Checksum:i6ED642C818B32791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69994 Genomic DNA. Translation: CAA49609.1.
CU329670 Genomic DNA. Translation: CAB11188.1.
PIRiS28392.
RefSeqiNP_594934.1. NM_001020365.2.

Genome annotation databases

EnsemblFungiiSPAC11E3.09.1; SPAC11E3.09.1:pep; SPAC11E3.09.
GeneIDi2541443.
KEGGispo:SPAC11E3.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69994 Genomic DNA. Translation: CAA49609.1 .
CU329670 Genomic DNA. Translation: CAB11188.1 .
PIRi S28392.
RefSeqi NP_594934.1. NM_001020365.2.

3D structure databases

ProteinModelPortali P32587.
ModBasei Search...

Protein-protein interaction databases

BioGridi 277948. 8 interactions.
MINTi MINT-4688440.
STRINGi 4896.SPAC11E3.09-1.

Proteomic databases

MaxQBi P32587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC11E3.09.1 ; SPAC11E3.09.1:pep ; SPAC11E3.09 .
GeneIDi 2541443.
KEGGi spo:SPAC11E3.09.

Organism-specific databases

PomBasei SPAC11E3.09.

Phylogenomic databases

eggNOGi COG5599.
KOi K01104.
OMAi NANQELQ.
OrthoDBi EOG7R573B.
PhylomeDBi P32587.

Miscellaneous databases

NextBioi 20802545.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pyp3 PTPase acts as a mitotic inducer in fission yeast."
    Millar J.B.A., Lenaers G., Russell P.
    EMBO J. 11:4933-4941(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPYP3_SCHPO
AccessioniPrimary (citable) accession number: P32587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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