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Protein

Protein SNQ2

Gene

SNQ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could be an ATP-dependent permease. Confers hyper-resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi889 – 8968ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  • cellular cation homeostasis Source: SGD
  • drug export Source: InterPro
  • drug transmembrane transport Source: GOC
  • response to drug Source: SGD
  • xenobiotic transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29630-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SNQ2
Gene namesi
Name:SNQ2
Ordered Locus Names:YDR011W
ORF Names:YD8119.16
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR011W.
SGDiS000002418. SNQ2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Transmembranei554 – 57421HelicalSequence analysisAdd
BLAST
Transmembranei600 – 62021HelicalSequence analysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence analysisAdd
BLAST
Transmembranei664 – 68017HelicalSequence analysisAdd
BLAST
Transmembranei771 – 78919HelicalSequence analysisAdd
BLAST
Transmembranei1190 – 121223HelicalSequence analysisAdd
BLAST
Transmembranei1216 – 123621HelicalSequence analysisAdd
BLAST
Transmembranei1277 – 129620HelicalSequence analysisAdd
BLAST
Transmembranei1333 – 135220HelicalSequence analysisAdd
BLAST
Transmembranei1455 – 147521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 15011500Protein SNQ2PRO_0000093441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei29 – 291PhosphoserineCombined sources
Modified residuei64 – 641PhosphoserineCombined sources
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei86 – 861PhosphoserineCombined sources
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence analysis
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence analysis
Glycosylationi730 – 7301N-linked (GlcNAc...)Sequence analysis
Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence analysis
Modified residuei1153 – 11531PhosphothreonineCombined sources
Glycosylationi1401 – 14011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32568.
PeptideAtlasiP32568.
PRIDEiP32568.

PTM databases

iPTMnetiP32568.

Interactioni

Protein-protein interaction databases

BioGridi32062. 54 interactions.
IntActiP32568. 24 interactions.
MINTiMINT-2731474.

Structurei

3D structure databases

ProteinModelPortaliP32568.
SMRiP32568. Positions 178-415, 821-1070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 410250ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini853 – 1095243ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP32568.
KOiK08712.
OrthoDBiEOG7N903S.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIKSTQDS SHNAVARSSS ASFAASEESF TGITHDKDEQ SDTPADKLTK
60 70 80 90 100
MLTGPARDTA SQISATVSEM APDVVSKVES FADALSRHTT RSGAFNMDSD
110 120 130 140 150
SDDGFDAHAI FESFVRDADE QGIHIRKAGV TIEDVSAKGV DASALEGATF
160 170 180 190 200
GNILCLPLTI FKGIKAKRHQ KMRQIISNVN ALAEAGEMIL VLGRPGAGCS
210 220 230 240 250
SFLKVTAGEI DQFAGGVSGE VAYDGIPQEE MMKRYKADVI YNGELDVHFP
260 270 280 290 300
YLTVKQTLDF AIACKTPALR VNNVSKKEYI ASRRDLYATI FGLRHTYNTK
310 320 330 340 350
VGNDFVRGVS GGERKRVSIA EALAAKGSIY CWDNATRGLD ASTALEYAKA
360 370 380 390 400
IRIMTNLLKS TAFVTIYQAS ENIYETFDKV TVLYSGKQIY FGLIHEAKPY
410 420 430 440 450
FAKMGYLCPP RQATAEFLTA LTDPNGFHLI KPGYENKVPR TAEEFETYWL
460 470 480 490 500
NSPEFAQMKK DIAAYKEKVN TEKTKEVYDE SMAQEKSKYT RKKSYYTVSY
510 520 530 540 550
WEQVKLCTQR GFQRIYGNKS YTVINVCSAI IQSFITGSLF YNTPSSTSGA
560 570 580 590 600
FSRGGVLYFA LLYYSLMGLA NISFEHRPIL QKHKGYSLYH PSAEAIGSTL
610 620 630 640 650
ASFPFRMIGL TCFFIILFFL SGLHRTAGSF FTIYLFLTMC SEAINGLFEM
660 670 680 690 700
VSSVCDTLSQ ANSISGILMM SISMYSTYMI QLPSMHPWFK WISYVLPIRY
710 720 730 740 750
AFESMLNAEF HGRHMDCANT LVPSGGDYDN LSDDYKVCAF VGSKPGQSYV
760 770 780 790 800
LGDDYLKNQF QYVYKHTWRN FGILWCFLLG YVVLKVIFTE YKRPVKGGGD
810 820 830 840 850
ALIFKKGSKR FIAHADEESP DNVNDIDAKE QFSSESSGAN DEVFDDLEAK
860 870 880 890 900
GVFIWKDVCF TIPYEGGKRM LLDNVSGYCI PGTMTALMGE SGAGKTTLLN
910 920 930 940 950
TLAQRNVGII TGDMLVNGRP IDASFERRTG YVQQQDIHIA ELTVRESLQF
960 970 980 990 1000
SARMRRPQHL PDSEKMDYVE KIIRVLGMEE YAEALVGEVG CGLNVEQRKK
1010 1020 1030 1040 1050
LSIGVELVAK PDLLLFLDEP TSGLDSQSSW AIIQLLRKLS KAGQSILCTI
1060 1070 1080 1090 1100
HQPSATLFEE FDRLLLLRKG GQTVYFGDIG KNSATILNYF ERNGARKCDS
1110 1120 1130 1140 1150
SENPAEYILE AIGAGATASV KEDWHEKWLN SVEFEQTKEK VQDLINDLSK
1160 1170 1180 1190 1200
QETKSEVGDK PSKYATSYAY QFRYVLIRTS TSFWRSLNYI MSKMMLMLVG
1210 1220 1230 1240 1250
GLYIGFTFFN VGKSYVGLQN AMFAAFISII LSAPAMNQIQ GRAIASRELF
1260 1270 1280 1290 1300
EVRESQSNMF HWSLVLITQY LSELPYHLFF STIFFVSSYF PLRIFFEASR
1310 1320 1330 1340 1350
SAVYFLNYCI MFQLYYVGLG LMILYMSPNL PSANVILGLC LSFMLSFCGV
1360 1370 1380 1390 1400
TQPVSLMPGF WTFMWKASPY TYFVQNLVGI MLHKKPVVCK KKELNYFNPP
1410 1420 1430 1440 1450
NGSTCGEYMK PFLEKATGYI ENPDATSDCA YCIYEVGDNY LTHISSKYSY
1460 1470 1480 1490 1500
LWRNFGIFWI YIFFNIIAMV CVYYLFHVRQ SSFLSPVSIL NKIKNIRKKK

Q
Length:1,501
Mass (Da):168,767
Last modified:February 1, 1996 - v2
Checksum:i96BE3D30CCFB76AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781V → E in CAA47270 (PubMed:8437567).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66732 Genomic DNA. Translation: CAA47270.1.
X95966 Genomic DNA. Translation: CAA65203.1.
Z48008 Genomic DNA. Translation: CAA88071.1.
Z74307 Genomic DNA. Translation: CAA98831.1.
BK006938 Genomic DNA. Translation: DAA11857.1.
PIRiS50992.
RefSeqiNP_010294.1. NM_001180319.1.

Genome annotation databases

EnsemblFungiiYDR011W; YDR011W; YDR011W.
GeneIDi851574.
KEGGisce:YDR011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66732 Genomic DNA. Translation: CAA47270.1.
X95966 Genomic DNA. Translation: CAA65203.1.
Z48008 Genomic DNA. Translation: CAA88071.1.
Z74307 Genomic DNA. Translation: CAA98831.1.
BK006938 Genomic DNA. Translation: DAA11857.1.
PIRiS50992.
RefSeqiNP_010294.1. NM_001180319.1.

3D structure databases

ProteinModelPortaliP32568.
SMRiP32568. Positions 178-415, 821-1070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32062. 54 interactions.
IntActiP32568. 24 interactions.
MINTiMINT-2731474.

Protein family/group databases

TCDBi3.A.1.205.2. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP32568.

Proteomic databases

MaxQBiP32568.
PeptideAtlasiP32568.
PRIDEiP32568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR011W; YDR011W; YDR011W.
GeneIDi851574.
KEGGisce:YDR011W.

Organism-specific databases

EuPathDBiFungiDB:YDR011W.
SGDiS000002418. SNQ2.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP32568.
KOiK08712.
OrthoDBiEOG7N903S.

Enzyme and pathway databases

BioCyciYEAST:G3O-29630-MONOMER.

Miscellaneous databases

NextBioi969028.
PROiP32568.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases."
    Servos J., Haase E., Brendel M.
    Mol. Gen. Genet. 236:214-218(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing and analysis of a 35.4 kb region on the right arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames."
    Eide L.G., Sander C., Prydz H.
    Yeast 12:1085-1090(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane."
    Decottignies A., Lambert L., Catty P., Degand H., Epping E.A., Moye-Rowley W.S., Balzi E., Goffeau A.
    J. Biol. Chem. 270:18150-18157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, PROTEIN SEQUENCE OF 1243-1247.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-64; SER-80; SER-86 AND THR-1153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-80 AND SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-80 AND THR-1153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNQ2_YEAST
AccessioniPrimary (citable) accession number: P32568
Secondary accession number(s): D6VRZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.