P32564 (SCM4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SCM4

Alternative name(s):
Suppressor of CDC4 mutation 4

Gene names

Name:	SCM4
Ordered Locus Names:	YGR049W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	Present with 3210 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ATG33 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial outer membrane Inferred from direct assay PubMed 16407407. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Protein SCM4		PRO_0000097626
Regions
	Transmembrane	11 – 31	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P32564 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 6DE7C5C791B13568	FASTA	187	20,118
	10 20 30 40 50 60 MQVSPAIVKG IAVSSLGLYA GILTSSTVIS ITTPINVLTQ HLKNVLCTLG CWSTVLGGLA 70 80 90 100 110 120 TGAFGLSYYL AAPGERPNYL LCGLGVAPLS AAYLYLVSLF NHKLAPKCTR DQNDLEKQKD 130 140 150 160 170 180 EKLPQHHPEV KDGEAACPFS KMNNAKTLKP ESERSVKCHS YMSLHMSIVT GITIFTFGKC ILDGFKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SCM4, a gene that suppresses mutant cdc4 function in budding yeast." Smith S.A., Kumar P., Johnston I., Rosamond J. Mol. Gen. Genet. 235:285-291(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69566 Genomic DNA. Translation: CAA49291.1. DQ115391 Genomic DNA. Translation: AAZ22464.1. Z72834 Genomic DNA. Translation: CAA97049.1. BK006941 Genomic DNA. Translation: DAA08147.1.
PIR	S30093.
RefSeq	NP_011563.1. NM_001181178.1.
3D structure databases
ProteinModelPortal	P32564.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1870N.
IntAct	P32564. 2 interactions.
MINT	MINT-408265.
STRING	4932.YGR049W.
Proteomic databases
PaxDb	P32564.
PeptideAtlas	P32564.
Protocols and materials databases
DNASU	852940.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR049W; YGR049W; YGR049W.
GeneID	852940.
KEGG	sce:YGR049W.
Organism-specific databases
CYGD	YGR049w.
SGD	S000003281. SCM4.
Phylogenomic databases
eggNOG	NOG68417.
GeneTree	ENSGT00530000067118.
HOGENOM	HOG000000951.
OMA	TGITIFT.
OrthoDB	EOG405W9X.
Gene expression databases
Genevestigator	P32564.
GermOnline	YGR049W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	972681.

Entry information

Entry name

SCM4_YEAST

Accession

Primary (citable) accession number: P32564
Secondary accession number(s): D6VUI6, Q45U35

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program