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P32561

- RPD3_YEAST

UniProt

P32561 - RPD3_YEAST

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Protein
Histone deacetylase RPD3
Gene
RPD3, MOF6, REC3, SDI2, SDS6, YNL330C, N0305
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Is involved in rDNA and telomere silencing and in double strand breaks repair. Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2. The RPD3 complexes regulate also chromosomal replication timing.19 Publications

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei151 – 1511 Inferred

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. histone deacetylase activity Source: SGD
  6. protein binding Source: IntAct
  7. transcription coactivator activity Source: SGD
  8. transcription corepressor activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. histone H3 deacetylation Source: SGD
  2. histone H4 deacetylation Source: SGD
  3. negative regulation of chromatin silencing at rDNA Source: SGD
  4. negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  5. negative regulation of chromatin silencing at telomere Source: SGD
  6. negative regulation of reciprocal meiotic recombination Source: SGD
  7. negative regulation of transcription during meiosis Source: SGD
  8. negative regulation of transcription from RNA polymerase I promoter Source: SGD
  9. negative regulation of transcription from RNA polymerase II promoter Source: SGD
  10. positive regulation of macroautophagy Source: SGD
  11. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  12. positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  13. protein localization to nucleolar rDNA repeats Source: SGD
  14. regulation of DNA-dependent DNA replication initiation Source: SGD
  15. regulation of transcription by chromatin organization Source: SGD
  16. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  17. regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  18. replicative cell aging Source: SGD
  19. transcription elongation from RNA polymerase II promoter Source: SGD
  20. transfer RNA gene-mediated silencing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase RPD3 (EC:3.5.1.98)
Alternative name(s):
Transcriptional regulatory protein RPD3
Gene namesi
Name:RPD3
Synonyms:MOF6, REC3, SDI2, SDS6
Ordered Locus Names:YNL330C
ORF Names:N0305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL330c.
SGDiS000005274. RPD3.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. Rpd3L complex Source: SGD
  2. Rpd3S complex Source: SGD
  3. Sin3-type complex Source: SGD
  4. cytoplasm Source: UniProtKB-SubCell
  5. histone deacetylase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi150 – 1501H → A: Impairs histone deacetylase activity and transcription repression. 1 Publication
Mutagenesisi151 – 1511H → A: Impairs histone deacetylase activity and transcription repression. 1 Publication
Mutagenesisi188 – 1881H → A: Impairs histone deacetylase activity and transcription repression. 1 Publication
Mutagenesisi322 – 3221W → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi325 – 3251E → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi327 – 3271G → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi328 – 3281L → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi329 – 3291L → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi332 – 3321V → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi334 – 3341L → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi335 – 3351D → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi338 – 3381L → A: Reduces strongly HDAC activity. 1 Publication
Mutagenesisi339 – 3391P → A: Reduces strongly HDAC activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histone deacetylase RPD3
PRO_0000114724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei394 – 3941Phosphothreonine2 Publications
Modified residuei408 – 4081Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32561.
PaxDbiP32561.
PeptideAtlasiP32561.

Expressioni

Gene expression databases

GenevestigatoriP32561.

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1. Interacts with cyclophilins CPR1, CPR6 and CPR7, with the kinase HOG1, and with ESS1, CYC8 and HAC1.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CPR6P536912EBI-15864,EBI-5429
CPR7P471032EBI-15864,EBI-5436
CYC8P149226EBI-15864,EBI-18215
HOT1Q032133EBI-15864,EBI-27376
RXT2P382556EBI-15864,EBI-21537
SIN3P2257911EBI-15864,EBI-17160
TUP1P166492EBI-15864,EBI-19654

Protein-protein interaction databases

BioGridi35511. 724 interactions.
DIPiDIP-681N.
IntActiP32561. 57 interactions.
MINTiMINT-614075.
STRINGi4932.YNL330C.

Structurei

3D structure databases

ProteinModelPortaliP32561.
SMRiP32561. Positions 18-380.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 331313Histone deacetylase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi320 – 34021ESA1-RPD3 motif
Add
BLAST

Domaini

The ESA1-RPD3 (ER) motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
KOiK06067.
OMAiYEYCSIS.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P32561-1 [UniParc]FASTAAdd to Basket

« Hide

MVYEATPFDP ITVKPSDKRR VAYFYDADVG NYAYGAGHPM KPHRIRMAHS    50
LIMNYGLYKK MEIYRAKPAT KQEMCQFHTD EYIDFLSRVT PDNLEMFKRE 100
SVKFNVGDDC PVFDGLYEYC SISGGGSMEG AARLNRGKCD VAVNYAGGLH 150
HAKKSEASGF CYLNDIVLGI IELLRYHPRV LYIDIDVHHG DGVEEAFYTT 200
DRVMTCSFHK YGEFFPGTGE LRDIGVGAGK NYAVNVPLRD GIDDATYRSV 250
FEPVIKKIME WYQPSAVVLQ CGGDSLSGDR LGCFNLSMEG HANCVNYVKS 300
FGIPMMVVGG GGYTMRNVAR TWCFETGLLN NVVLDKDLPY NEYYEYYGPD 350
YKLSVRPSNM FNVNTPEYLD KVMTNIFANL ENTKYAPSVQ LNHTPRDAED 400
LGDVEEDSAE AKDTKGGSQY ARDLHVEHDN EFY 433
Length:433
Mass (Da):48,904
Last modified:October 1, 1993 - v1
Checksum:i34FFD72A7E7425DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66438 Genomic DNA. Translation: AAB20328.1.
X83226 Genomic DNA. Translation: CAA58228.1.
Z46259 Genomic DNA. Translation: CAA86368.1.
Z71605 Genomic DNA. Translation: CAA96262.1.
Z71606 Genomic DNA. Translation: CAA96263.1.
AY692813 Genomic DNA. Translation: AAT92832.1.
BK006947 Genomic DNA. Translation: DAA10233.1.
PIRiS22284.
RefSeqiNP_014069.1. NM_001183168.1.

Genome annotation databases

EnsemblFungiiYNL330C; YNL330C; YNL330C.
GeneIDi855386.
KEGGisce:YNL330C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66438 Genomic DNA. Translation: AAB20328.1 .
X83226 Genomic DNA. Translation: CAA58228.1 .
Z46259 Genomic DNA. Translation: CAA86368.1 .
Z71605 Genomic DNA. Translation: CAA96262.1 .
Z71606 Genomic DNA. Translation: CAA96263.1 .
AY692813 Genomic DNA. Translation: AAT92832.1 .
BK006947 Genomic DNA. Translation: DAA10233.1 .
PIRi S22284.
RefSeqi NP_014069.1. NM_001183168.1.

3D structure databases

ProteinModelPortali P32561.
SMRi P32561. Positions 18-380.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35511. 724 interactions.
DIPi DIP-681N.
IntActi P32561. 57 interactions.
MINTi MINT-614075.
STRINGi 4932.YNL330C.

Proteomic databases

MaxQBi P32561.
PaxDbi P32561.
PeptideAtlasi P32561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL330C ; YNL330C ; YNL330C .
GeneIDi 855386.
KEGGi sce:YNL330C.

Organism-specific databases

CYGDi YNL330c.
SGDi S000005274. RPD3.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062889.
HOGENOMi HOG000225180.
KOi K06067.
OMAi YEYCSIS.
OrthoDBi EOG78M0B2.

Enzyme and pathway databases

BioCyci YEAST:G3O-33314-MONOMER.

Miscellaneous databases

NextBioi 979187.

Gene expression databases

Genevestigatori P32561.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae."
    Vidal M., Gaber R.F.
    Mol. Cell. Biol. 11:6317-6327(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase."
    van Dyck L., Pascual-Ahuir A., Purnelle B., Goffeau A.
    Yeast 11:987-991(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "Sequencing analysis of a 15.4 kb fragment of yeast chromosome XIV identifies the RPD3, PAS8 and KRE1 loci, five new open reading frames."
    Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.
    Yeast 11:567-572(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-201.
    Strain: S288c / FY1676.
  7. "Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae."
    Vannier D., Balderes D., Shore D.
    Genetics 144:1343-1353(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 200060 / W303.
  8. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
    Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
    Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A HISTONE DEACETYLASE COMPLEX.
  9. "Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth."
    Duina A.A., Marsh J.A., Gaber R.F.
    Yeast 12:943-952(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPR6 AND CPR7.
  10. "A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators."
    Kasten M.M., Dorland S., Stillman D.J.
    Mol. Cell. Biol. 17:4852-4858(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RPD3 COMPLEX.
  11. "Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo."
    Kadosh D., Struhl K.
    Genes Dev. 12:797-805(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF HIS-150; HIS-151 AND HIS-188.
  12. "Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo."
    Kadosh D., Struhl K.
    Mol. Cell. Biol. 18:5121-5127(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPD3 COMPLEX.
  13. "Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3."
    Rundlett S.E., Carmen A.A., Suka N., Turner B.M., Grunstein M.
    Nature 392:831-835(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEACETYLATION OF HISTONE H4.
  14. "RPD3 (REC3) mutations affect mitotic recombination in Saccharomyces cerevisiae."
    Dora E.G., Rudin N., Martell J.R., Esposito M.S., Ramirez R.M.
    Curr. Genet. 35:68-76(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae."
    Sun Z.-W., Hampsey M.
    Genetics 152:921-932(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPD3 COMPLEX.
  16. "GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast."
    Burgess S.M., Ajimura M., Kleckner N.
    Proc. Natl. Acad. Sci. U.S.A. 96:6835-6840(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase."
    Arevalo-Rodriguez M., Cardenas M.E., Wu X., Hanes S.D., Heitman J.
    EMBO J. 19:3739-3749(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPR1 AND ESS1.
  18. "Ssn6-Tup1 interacts with class I histone deacetylases required for repression."
    Watson A.D., Edmondson D.G., Bone J.R., Mukai Y., Yu Y., Du W., Stillman D.J., Roth S.Y.
    Genes Dev. 14:2737-2744(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes."
    Elkhaimi M., Kaadige M.R., Kamath D., Jackson J.C., Biliran H. Jr., Lopes J.M.
    Nucleic Acids Res. 28:3160-3167(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase."
    Sandmeier J.J., French S., Osheim Y., Cheung W.L., Gallo C.M., Beyer A.L., Smith J.S.
    EMBO J. 21:4959-4968(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CYC8.
  21. "A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3."
    Adachi N., Kimura A., Horikoshi M.
    J. Biol. Chem. 277:35688-35695(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, MUTAGENESIS OF TRP-322; GLU-325; GLY-327; LEU-328; LEU-329; VAL-332; LEU-334; ASP-335; LEU-338 AND PRO-339.
  22. "Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein."
    Deckert J., Struhl K.
    Mol. Cell. Biol. 22:6458-6470(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  23. "Genome-wide binding map of the histone deacetylase Rpd3 in yeast."
    Kurdistani S.K., Robyr D., Tavazoie S., Grunstein M.
    Nat. Genet. 31:248-254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  24. "Opposite role of yeast ING family members in p53-dependent transcriptional activation."
    Nourani A., Howe L., Pray-Grant M.G., Workman J.L., Grant P.A., Cote J.
    J. Biol. Chem. 278:19171-19175(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RPD3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  25. "Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae."
    Scott K.L., Plon S.E.
    Mol. Cell. Biol. 23:4522-4531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPD3 COMPLEX.
  26. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  27. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  28. "The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase."
    Schroeder M., Clark R., Liu C.Y., Kaufman R.J.
    EMBO J. 23:2281-2292(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HAC1, FUNCTION OF THE RPD3 COMPLEX.
  29. "The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae."
    Aparicio J.G., Viggiani C.J., Gibson D.G., Aparicio O.M.
    Mol. Cell. Biol. 24:4769-4780(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  30. "Genome-wide analysis of the relationship between transcriptional regulation by Rpd3p and the histone H3 and H4 amino termini in budding yeast."
    Sabet N., Volo S., Yu C., Madigan J.P., Morse R.H.
    Mol. Cell. Biol. 24:8823-8833(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  31. "The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes."
    De Nadal E., Zapater M., Alepuz P.M., Sumoy L., Mas G., Posas F.
    Nature 427:370-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOG1, FUNCTION OF THE RPD3 COMPLEX.
  32. "Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair."
    Jazayeri A., McAinsh A.D., Jackson S.P.
    Proc. Natl. Acad. Sci. U.S.A. 101:1644-1649(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPD3 COMPLEX.
  33. "Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex."
    Carrozza M.J., Florens L., Swanson S.K., Shia W.-J., Anderson S., Yates J., Washburn M.P., Workman J.L.
    Biochim. Biophys. Acta 1731:77-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  34. Cited for: IDENTIFICATION IN THE RPD3C(L) AND RPD3C(S) COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION OF THE RPD3C(S) COMPLEX.
  35. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  36. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  37. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPD3_YEAST
AccessioniPrimary (citable) accession number: P32561
Secondary accession number(s): D6W0L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3850 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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