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P32556

- CYC_KLULA

UniProt

P32556 - CYC_KLULA

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Protein

Cytochrome c

Gene

CYCK

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211Heme (covalent)PROSITE-ProRule annotation
Binding sitei24 – 241Heme (covalent)PROSITE-ProRule annotation
Metal bindingi25 – 251Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi87 – 871Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYCK
Synonyms:CYTC1
Ordered Locus Names:KLLA0F16929g/KLLA0F16940g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Cytochrome cPRO_0000108327Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PRIDEiP32556.

Interactioni

Protein-protein interaction databases

STRINGi28985.P32556.

Structurei

3D structure databases

ProteinModelPortaliP32556.
SMRiP32556. Positions 5-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009762.
InParanoidiP32556.
KOiK08738.
OrthoDBiEOG71RXXT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32556-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAPYKKGSE KKGATLFKTR CLQCHTVEAG GPHKVGPNLH GVFGRHSGKA
60 70 80 90 100
SGYSYTDANI KKNVLWDEQT MSDYLENPKK YIPGTKMAFG GLKKEKDRND
110
IVTYMLKACK
Length:110
Mass (Da):12,238
Last modified:October 1, 1993 - v1
Checksum:i200B5653F587787C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60834 Genomic DNA. Translation: CAA43224.1.
X58150 Genomic DNA. Translation: CAA41156.1.
CR382126 Genomic DNA. Translation: CAG98548.1.
PIRiS29350.
RefSeqiXP_455841.1. XM_455841.1.

Genome annotation databases

GeneIDi2894947.
KEGGikla:KLLA0F16929g.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60834 Genomic DNA. Translation: CAA43224.1 .
X58150 Genomic DNA. Translation: CAA41156.1 .
CR382126 Genomic DNA. Translation: CAG98548.1 .
PIRi S29350.
RefSeqi XP_455841.1. XM_455841.1.

3D structure databases

ProteinModelPortali P32556.
SMRi P32556. Positions 5-110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P32556.

Proteomic databases

PRIDEi P32556.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2894947.
KEGGi kla:KLLA0F16929g.

Phylogenomic databases

eggNOGi COG3474.
HOGENOMi HOG000009762.
InParanoidi P32556.
KOi K08738.
OrthoDBi EOG71RXXT.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cytochrome c gene from Kluyveromyces lactis and its upstream region."
    Picos M.A.F., Rodriguez Torres A.M., Ramil E., Cerdan M.E., Breunig K.D., Hollenberg C.P., Zitomer R.S.
    Yeast 9:201-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  2. "Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals."
    Clark-Walker G.D.
    Curr. Genet. 20:195-198(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 90735 / K8.
  3. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiCYC_KLULA
AccessioniPrimary (citable) accession number: P32556
Secondary accession number(s): Q6CJP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3