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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

Uqcrc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

GO - Molecular functioni

  • metal ion binding Source: InterPro
  • metalloendopeptidase activity Source: InterPro
  • protein complex binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Protein family/group databases

MEROPSiM16.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:Uqcrc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359150. Uqcrc2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • mitochondrial respiratory chain complex III Source: RGD
  • mitochondrion Source: RGD
  • myelin sheath Source: Ensembl
  • nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionBy similarityAdd
BLAST
Chaini15 – 452438Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000026793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651N6-acetyllysineBy similarity
Modified residuei198 – 1981N6-acetyllysineBy similarity
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei367 – 3671PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP32551.
PRIDEiP32551.

2D gel databases

World-2DPAGE0004:P32551.

PTM databases

iPTMnetiP32551.
PhosphoSiteiP32551.

Expressioni

Tissue specificityi

Expressed in the head region and flagellum of epididymal sperm.1 Publication

Gene expression databases

GenevisibleiP32551. RN.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi254272. 1 interaction.
IntActiP32551. 3 interactions.
MINTiMINT-4996643.
STRINGi10116.ENSRNOP00000021514.

Structurei

3D structure databases

ProteinModelPortaliP32551.
SMRiP32551. Positions 34-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2583. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074666.
HOGENOMiHOG000046923.
HOVERGENiHBG055236.
InParanoidiP32551.
KOiK00415.
OMAiTRENMIY.
OrthoDBiEOG79CXZF.
PhylomeDBiP32551.
TreeFamiTF105033.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 3 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLSRAGSF SRFYSLKVAP KLKTSAPGGV PLQPQELEFT KLPNGLVIAS
60 70 80 90 100
LENYAPLSRI GLFIKAGSRY ENYNYLGTSH LLRLASTLTT KGASSFKITR
110 120 130 140 150
GIEAVGGKLS VTATRENMAY TVEGIRDDIE ILMEFLLNVT TAPEFRRWEV
160 170 180 190 200
AALRSQLKID KAVAFQNPQT RIIENLHDVA YKNALANPLY CPDYRMGKIT
210 220 230 240 250
SEELHYFVQN HFTSARMALV GLGVSHSILK EVAEQFLNIR GGLGLAGAKA
260 270 280 290 300
KYRGGEIREQ NGDNLVHAAI VAESAAIGNA EANAFSVLQH LLGAGPHIKR
310 320 330 340 350
GNNTTSLLSQ SVAKGSQQPF DVSAFNASYS DSGLFGIYTV SQAAAAGDVI
360 370 380 390 400
NAAYNQVKAV AQGNLSSADV QAAKNKLKAG YLMSVETSEG FLSEIGSQAL
410 420 430 440 450
ATGSYMPPPT VLQQIDAVAD ADVVKAAKKF VSGKKSMTAS GNLGHTPFLD

EL
Length:452
Mass (Da):48,396
Last modified:January 9, 2007 - v2
Checksum:iF4FFCA59CEB04270
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451H → N (PubMed:2162168).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083610 mRNA. Translation: AAH83610.1.
PIRiS29510.
RefSeqiNP_001006971.1. NM_001006970.1.
UniGeneiRn.2334.

Genome annotation databases

EnsembliENSRNOT00000021514; ENSRNOP00000021514; ENSRNOG00000036742.
GeneIDi293448.
KEGGirno:293448.
UCSCiRGD:1359150. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083610 mRNA. Translation: AAH83610.1.
PIRiS29510.
RefSeqiNP_001006971.1. NM_001006970.1.
UniGeneiRn.2334.

3D structure databases

ProteinModelPortaliP32551.
SMRiP32551. Positions 34-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254272. 1 interaction.
IntActiP32551. 3 interactions.
MINTiMINT-4996643.
STRINGi10116.ENSRNOP00000021514.

Protein family/group databases

MEROPSiM16.974.

PTM databases

iPTMnetiP32551.
PhosphoSiteiP32551.

2D gel databases

World-2DPAGE0004:P32551.

Proteomic databases

PaxDbiP32551.
PRIDEiP32551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021514; ENSRNOP00000021514; ENSRNOG00000036742.
GeneIDi293448.
KEGGirno:293448.
UCSCiRGD:1359150. rat.

Organism-specific databases

CTDi7385.
RGDi1359150. Uqcrc2.

Phylogenomic databases

eggNOGiKOG2583. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074666.
HOGENOMiHOG000046923.
HOVERGENiHBG055236.
InParanoidiP32551.
KOiK00415.
OMAiTRENMIY.
OrthoDBiEOG79CXZF.
PhylomeDBiP32551.
TreeFamiTF105033.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Miscellaneous databases

PROiP32551.

Gene expression databases

GenevisibleiP32551. RN.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 3 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of the precursor to core protein II, a putative member of mitochondrial processing protease family, of rat mitochondrial cytochrome bc1 complex deduced from cDNA sequence analysis."
    Hosokawa Y., Suzuki H., Toda H., Nishikimi M., Ozawa T.
    Biochem. Int. 20:731-737(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 42-59; 183-195 AND 231-240, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "Identification of novel immunodominant epididymal sperm proteins using combinatorial approach."
    Khan S.A., Suryawanshi A.R., Ranpura S.A., Jadhav S.V., Khole V.V.
    Reproduction 138:81-93(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQCR2_RAT
AccessioniPrimary (citable) accession number: P32551
Secondary accession number(s): Q5XIR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lackS the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.