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Protein

ETS-related transcription factor Elf-1

Gene

ELF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120690-MONOMER.
SIGNORiP32519.

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-1
Alternative name(s):
E74-like factor 1
Gene namesi
Name:ELF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:3316. ELF1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1997.
OpenTargetsiENSG00000120690.
PharmGKBiPA27744.

Polymorphism and mutation databases

BioMutaiELF1.
DMDMi212288097.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040851 – 619ETS-related transcription factor Elf-1Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei190PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP32519.
MaxQBiP32519.
PaxDbiP32519.
PeptideAtlasiP32519.
PRIDEiP32519.

PTM databases

iPTMnetiP32519.
PhosphoSitePlusiP32519.

Expressioni

Tissue specificityi

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.2 Publications

Gene expression databases

BgeeiENSG00000120690.
CleanExiHS_ELF1.
ExpressionAtlasiP32519. baseline and differential.
GenevisibleiP32519. HS.

Organism-specific databases

HPAiCAB005172.
HPA001755.
HPA048866.

Interactioni

Subunit structurei

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HOXC13P312763EBI-765526,EBI-2293590
SP1P080472EBI-765526,EBI-298336

Protein-protein interaction databases

BioGridi108312. 8 interactors.
DIPiDIP-185N.
IntActiP32519. 14 interactors.
MINTiMINT-144425.
STRINGi9606.ENSP00000239882.

Structurei

3D structure databases

ProteinModelPortaliP32519.
SMRiP32519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Asp6

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiP32519.
KOiK09428.
OMAiHLHTVTL.
OrthoDBiEOG091G04RR.
PhylomeDBiP32519.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE
110 120 130 140 150
AAEALLNMDS PGPMLDEKRI NNNIFSSPED DMVVAPVTHV SVTLDGIPEV
160 170 180 190 200
METQQVQEKY ADSPGASSPE QPKRKKGRKT KPPRPDSPAT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN
310 320 330 340 350
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS
360 370 380 390 400
KAAKPKDPVE VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA
410 420 430 440 450
ARTSTMQDET LNSSVQSIRT IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT
460 470 480 490 500
VIASTDPSAG TGSQKFILQA IPSSQPMTVL KENVMLQSQK AGSPPSIVLG
510 520 530 540 550
PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR SSQLVAHPPG
560 570 580 590 600
TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN
610
GFTSQVAMKQ NELLEPNSF
Length:619
Mass (Da):67,498
Last modified:July 22, 2008 - v2
Checksum:iFA0A51B3965616F3
GO
Isoform 2 (identifier: P32519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-145: Missing.

Note: No experimental confirmation available.
Show »
Length:595
Mass (Da):64,929
Checksum:iCAF5EFA51EFAE710
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04894258N → S.1 PublicationCorresponds to variant rs7799dbSNPEnsembl.1
Natural variantiVAR_048943343T → S.1 PublicationCorresponds to variant rs1056820dbSNPEnsembl.1
Natural variantiVAR_048944403T → I.Corresponds to variant rs7323148dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045682122 – 145Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82882 mRNA. No translation available.
AK304289 mRNA. Translation: BAG65147.1.
AL157877 Genomic DNA. Translation: CAI13220.1.
CH471075 Genomic DNA. Translation: EAX08640.1.
BC030507 mRNA. Translation: AAH30507.1.
CCDSiCCDS45043.1. [P32519-2]
CCDS9374.1. [P32519-1]
PIRiA43361.
RefSeqiNP_001138825.1. NM_001145353.1. [P32519-2]
NP_758961.1. NM_172373.3. [P32519-1]
XP_005266333.1. XM_005266276.1. [P32519-1]
XP_005266334.1. XM_005266277.3. [P32519-1]
XP_011533252.1. XM_011534950.1. [P32519-1]
XP_016875898.1. XM_017020409.1. [P32519-1]
XP_016875899.1. XM_017020410.1. [P32519-1]
XP_016875900.1. XM_017020411.1. [P32519-1]
XP_016875901.1. XM_017020412.1. [P32519-1]
XP_016875902.1. XM_017020413.1. [P32519-1]
UniGeneiHs.135646.

Genome annotation databases

EnsembliENST00000239882; ENSP00000239882; ENSG00000120690. [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690. [P32519-2]
GeneIDi1997.
KEGGihsa:1997.
UCSCiuc001uxs.4. human. [P32519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82882 mRNA. No translation available.
AK304289 mRNA. Translation: BAG65147.1.
AL157877 Genomic DNA. Translation: CAI13220.1.
CH471075 Genomic DNA. Translation: EAX08640.1.
BC030507 mRNA. Translation: AAH30507.1.
CCDSiCCDS45043.1. [P32519-2]
CCDS9374.1. [P32519-1]
PIRiA43361.
RefSeqiNP_001138825.1. NM_001145353.1. [P32519-2]
NP_758961.1. NM_172373.3. [P32519-1]
XP_005266333.1. XM_005266276.1. [P32519-1]
XP_005266334.1. XM_005266277.3. [P32519-1]
XP_011533252.1. XM_011534950.1. [P32519-1]
XP_016875898.1. XM_017020409.1. [P32519-1]
XP_016875899.1. XM_017020410.1. [P32519-1]
XP_016875900.1. XM_017020411.1. [P32519-1]
XP_016875901.1. XM_017020412.1. [P32519-1]
XP_016875902.1. XM_017020413.1. [P32519-1]
UniGeneiHs.135646.

3D structure databases

ProteinModelPortaliP32519.
SMRiP32519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108312. 8 interactors.
DIPiDIP-185N.
IntActiP32519. 14 interactors.
MINTiMINT-144425.
STRINGi9606.ENSP00000239882.

PTM databases

iPTMnetiP32519.
PhosphoSitePlusiP32519.

Polymorphism and mutation databases

BioMutaiELF1.
DMDMi212288097.

Proteomic databases

EPDiP32519.
MaxQBiP32519.
PaxDbiP32519.
PeptideAtlasiP32519.
PRIDEiP32519.

Protocols and materials databases

DNASUi1997.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239882; ENSP00000239882; ENSG00000120690. [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690. [P32519-2]
GeneIDi1997.
KEGGihsa:1997.
UCSCiuc001uxs.4. human. [P32519-1]

Organism-specific databases

CTDi1997.
DisGeNETi1997.
GeneCardsiELF1.
HGNCiHGNC:3316. ELF1.
HPAiCAB005172.
HPA001755.
HPA048866.
MIMi189973. gene.
neXtProtiNX_P32519.
OpenTargetsiENSG00000120690.
PharmGKBiPA27744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiP32519.
KOiK09428.
OMAiHLHTVTL.
OrthoDBiEOG091G04RR.
PhylomeDBiP32519.
TreeFamiTF318679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120690-MONOMER.
SIGNORiP32519.

Miscellaneous databases

ChiTaRSiELF1. human.
GenomeRNAii1997.
PROiP32519.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120690.
CleanExiHS_ELF1.
ExpressionAtlasiP32519. baseline and differential.
GenevisibleiP32519. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELF1_HUMAN
AccessioniPrimary (citable) accession number: P32519
Secondary accession number(s): B4E2I5
, E9PDQ9, Q8N6F6, Q9UDE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.