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Protein

Lysine-specific permease

Gene

LYP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity permease for lysine.1 Publication

Miscellaneous

Present with 2580 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • basic amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • basic amino acid transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33262-MONOMER

Protein family/group databases

TCDBi2.A.3.10.10 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific permease
Gene namesi
Name:LYP1
Ordered Locus Names:YNL268W
ORF Names:N0790
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL268W
SGDiS000005212 LYP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicSequence analysisAdd BLAST115
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 141ExtracellularSequence analysis5
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 185CytoplasmicSequence analysisAdd BLAST23
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 223ExtracellularSequence analysisAdd BLAST18
Transmembranei224 – 243HelicalSequence analysisAdd BLAST20
Topological domaini244 – 256CytoplasmicSequence analysisAdd BLAST13
Transmembranei257 – 274HelicalSequence analysisAdd BLAST18
Topological domaini275 – 303ExtracellularSequence analysisAdd BLAST29
Transmembranei304 – 321HelicalSequence analysisAdd BLAST18
Topological domaini322 – 344CytoplasmicSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 398ExtracellularSequence analysisAdd BLAST33
Transmembranei399 – 418HelicalSequence analysisAdd BLAST20
Topological domaini419 – 445CytoplasmicSequence analysisAdd BLAST27
Transmembranei446 – 464HelicalSequence analysisAdd BLAST19
Topological domaini465 – 473ExtracellularSequence analysis9
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 513CytoplasmicSequence analysisAdd BLAST19
Transmembranei514 – 532HelicalSequence analysisAdd BLAST19
Topological domaini533 – 547ExtracellularSequence analysisAdd BLAST15
Transmembranei548 – 566HelicalSequence analysisAdd BLAST19
Topological domaini567 – 611CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541561 – 611Lysine-specific permeaseAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei64PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei90PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP32487
PaxDbiP32487
PRIDEiP32487

PTM databases

iPTMnetiP32487

Interactioni

Protein-protein interaction databases

BioGridi35572, 33 interactors
IntActiP32487, 5 interactors
MINTiP32487
STRINGi4932.YNL268W

Structurei

3D structure databases

ProteinModelPortaliP32487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261850
InParanoidiP32487
KOiK16261
OMAiFFAESEF
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P32487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRFSNIITS NKWDEKQNNI GEQSMQELPE DQIEHEMEAI DPSNKTTPYS
60 70 80 90 100
IDEKQYNTKK KHGSLQGGAI ADVNSITNSL TRLQVVSHET DINEDEEEAH
110 120 130 140 150
YEDKHVKRAL KQRHIGMIAL GGTIGTGLFV GISTPLSNAG PVGSLIAYIF
160 170 180 190 200
MGTIVYFVTQ SLGEMATFIP VTSSITVFSK RFLSPAFGVS NGYMYWFNWA
210 220 230 240 250
ITYAVEVSVI GQVIEYWTDK VPLAAWIAIF WVIITLMNFF PVKVYGEFEF
260 270 280 290 300
WVASVKVLAI MGYLIYALII VCGGSHQGPI GFRYWRNPGA WGPGIISSDK
310 320 330 340 350
SEGRFLGWVS SLINAAFTYQ GTELVGITAG EAANPRKTVP RAINKVVFRI
360 370 380 390 400
VLFYIMSLFF IGLLVPYNDS RLSASSAVIA SSPFVISIQN AGTYALPDIF
410 420 430 440 450
NAVVLITVVS AANSNVYVGS RVLYSLARTG NAPKQFGYVT RQGVPYLGVV
460 470 480 490 500
CTAALGLLAF LVVNNNANTA FNWLINISTL AGLCAWLFIS LAHIRFMQAL
510 520 530 540 550
KHRGISRDDL PFKAKLMPYG AYYAAFFVTV IIFIQGFQAF CPFKVSEFFT
560 570 580 590 600
SYISLILLAV VFIGCQIYYK CRFIWKLEDI DIDSDRREIE AIIWEDDEPK
610
NLWEKFWAAV A
Length:611
Mass (Da):68,090
Last modified:October 1, 1996 - v2
Checksum:i4E7AF6F7F5F1461B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90T → P in CAA47729 (PubMed:8368011).Curated1
Sequence conflicti93N → D in CAA47729 (PubMed:8368011).Curated1
Sequence conflicti561V → M in CAA47729 (PubMed:8368011).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67315 Genomic DNA Translation: CAA47729.1
X92494 Genomic DNA Translation: CAA63230.1
Z71544 Genomic DNA Translation: CAA96175.1
BK006947 Genomic DNA Translation: DAA10292.1
PIRiS60914
RefSeqiNP_014131.1, NM_001183106.1

Genome annotation databases

EnsemblFungiiYNL268W; YNL268W; YNL268W
GeneIDi855453
KEGGisce:YNL268W

Similar proteinsi

Entry informationi

Entry nameiLYP1_YEAST
AccessioniPrimary (citable) accession number: P32487
Secondary accession number(s): D6W0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health