Reviewed, UniProtKB/Swiss-Prot P32483 (PABS_STRGR)

Names and origin

Protein names

Recommended name:
    Para-aminobenzoate synthase
    EC=2.6.1.85
Alternative name(s):
    P-aminobenzoic acid synthase
      Short name=PABA synthase

Gene names

Name:

pab

Organism

Streptomyces griseus

Taxonomic identifier

1911 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Antibiotic biosynthesis; candicidin biosynthesis.
Sequence similarities	In the C-terminal section; belongs to the anthranilate synthase component I family. Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis Folate biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC anthranilate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Para-aminobenzoate synthase		PRO_0000154141
Regions
	Domain	1 – 195	195	Glutamine amidotransferase type-1
	Region	255 – 723	469	PABB component
Sites
	Active site	82	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P32483-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 1251547F82DA100F	FASTA	723	77,901
	10 20 30 40 50 60 MRTLLVDNYD SFTYNLFHYL SRANGREPEV IRNDDPAWRP GLLDAFDNVV LSPGPGTPHR 70 80 90 100 110 120 PADFGLCARI AEEGRLPVLG VCLGHQGMAL AHGARVGRAP EPRHGRTSAV RHDGTGLFEG 130 140 150 160 170 180 LPQPLEVVRY HSLAVTELPP ELEATAWSED GVLMALRHRT LPLWGVQFHP ESIGTQDGHR 190 200 210 220 230 240 LLANFRDLTE RHGRTRHGGR AGHGTLPPPA PARETKATTG TPRRLRVIAK SLPTRWDAEV 250 260 270 280 290 300 AFDSLFRTGD HPFWLDSSRP GGELGQLSMM GDASGPLART AKADVHAGTV TVRADGASST 310 320 330 340 350 360 VESAFLTWLE NDLAGLRTEV PELPFAFALG WVGCLGYELK AECDGDAAHR SPDPDAVLVF 370 380 390 400 410 420 ADRALVLDHR TRTTYLLALV EDDAEAEARA WLAAASATLD AVAGREPEPC PEAPVCTTGP 430 440 450 460 470 480 VELRHDRDGY LKLIDVCQQE IAAGETYEVC LTNMAEADTD LTPWAAYRAL RRVSPAPFAA 490 500 510 520 530 540 FLDFGPMAVL SSSPERFLRI DRHGRMESKP IKGTRPRGAT PQEDAALVRA LATCEKDRAE 550 560 570 580 590 600 NLMIVDLVRH DLGRCAEVGS VVADPVFQVE TYATVHQLVS TVTARLREDS SPVAAVRAAF 610 620 630 640 650 660 PGGSMTGAPK IRTMQIIDRL EGGPRGVYSG AIGYFSLTGA VDLSIVIRTV VLSGGRLRYG 670 680 690 700 710 720 VGGAVIALSD PADEFEETAV KAAPLLRLLD TAFPGRERPG KDLDGEPDDG TDAGAPKDLV LPG

References

[1]

"The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid synthase, is located between genes possibly involved in candicidin biosynthesis." Criado L.M., Martin J.F., Gil J.A. Gene 126:135-139(1993) [PubMed: 8472954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IMRU 3570.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M93058 Unassigned DNA. Translation: AAA72111.1.
PIR	JN0531.
3D structure databases
SMR	P32483. Positions 1-195, 230-690.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.85. 1270.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR006220. Anth_synthII. IPR001317. CarbamoylP_synth_GATase_dom. IPR015890. Chorismate-bd_C. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR005802. Para-NH2Bz_synth_comp_1. IPR006221. TrpG_papA. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. PF00117. GATase. 1 hit. [Graphical view]
PRINTS	PR00097. ANTSNTHASEII. PR00099. CPSGATASE. PR00096. GATASE.
TIGRFAMs	TIGR00553. pabB. 1 hit. TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABS_STRGR

Accession

Primary (citable) accession number: P32483

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	February 9, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)