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Protein

Peptidyl-prolyl cis-trans isomerase FPR2

Gene

FPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP-13 may play a role in protein trafficking in the ER.

Miscellaneous

Present with 5400 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin. Binds FK506 with 15-fold lower affinity than FKB1.

GO - Molecular functioni

  • FK506 binding Source: SGD
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YDR519W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FPR2 (EC:5.2.1.8)
Short name:
PPIase FPR2
Alternative name(s):
FK506-binding protein 2
FKBP proline rotamase 2
FKBP-13
FKBP-15
Gene namesi
Name:FPR2
Synonyms:FKB2
Ordered Locus Names:YDR519W
ORF Names:D9719.24
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR519W
SGDiS000002927 FPR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002551218 – 135Peptidyl-prolyl cis-trans isomerase FPR2Add BLAST118

Proteomic databases

MaxQBiP32472
PaxDbiP32472
PRIDEiP32472

Interactioni

Protein-protein interaction databases

BioGridi32570, 38 interactors
IntActiP32472, 45 interactors
MINTiP32472
STRINGi4932.YDR519W

Structurei

3D structure databases

ProteinModelPortaliP32472
SMRiP32472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 132PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
InParanoidiP32472
KOiK09569
OMAiGILGMCE
OrthoDBiEOG092C52SD

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFNIYLFVT FFSTILAGSL SDLEIGIIKR IPVEDCLIKA MPGDKVKVHY
60 70 80 90 100
TGSLLESGTV FDSSYSRGSP IAFELGVGRV IKGWDQGVAG MCVGEKRKLQ
110 120 130
IPSSLAYGER GVPGVIPPSA DLVFDVELVD VKSAA
Length:135
Mass (Da):14,487
Last modified:October 1, 1993 - v1
Checksum:i09CA3F1568D7E4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90646 Genomic DNA Translation: AAA34604.1
M90767 Genomic DNA Translation: AAA34605.1
U33057 Genomic DNA Translation: AAB64960.1
AY558177 Genomic DNA Translation: AAS56503.1
BK006938 Genomic DNA Translation: DAA12350.1
PIRiS25337
RefSeqiNP_010807.3, NM_001180827.3

Genome annotation databases

EnsemblFungiiYDR519W; YDR519W; YDR519W
GeneIDi852131
KEGGisce:YDR519W

Similar proteinsi

Entry informationi

Entry nameiFKBP2_YEAST
AccessioniPrimary (citable) accession number: P32472
Secondary accession number(s): D6VTE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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