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Protein

Peptidyl-prolyl cis-trans isomerase FPR2

Gene

FPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP-13 may play a role in protein trafficking in the ER.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin. Binds FK506 with 15-fold lower affinity than FKB1.

GO - Molecular functioni

  • FK506 binding Source: SGD
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YDR519W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FPR2 (EC:5.2.1.8)
Short name:
PPIase FPR2
Alternative name(s):
FK506-binding protein 2
FKBP proline rotamase 2
FKBP-13
FKBP-15
Gene namesi
Name:FPR2
Synonyms:FKB2
Ordered Locus Names:YDR519W
ORF Names:D9719.24
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR519W.
SGDiS000002927. FPR2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 135118Peptidyl-prolyl cis-trans isomerase FPR2PRO_0000025512Add
BLAST

Proteomic databases

MaxQBiP32472.

Interactioni

Protein-protein interaction databases

BioGridi32570. 22 interactions.
IntActiP32472. 45 interactions.
MINTiMINT-2779497.

Structurei

3D structure databases

ProteinModelPortaliP32472.
SMRiP32472. Positions 39-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 13290PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
InParanoidiP32472.
KOiK09569.
OMAiRIPVEDC.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFNIYLFVT FFSTILAGSL SDLEIGIIKR IPVEDCLIKA MPGDKVKVHY
60 70 80 90 100
TGSLLESGTV FDSSYSRGSP IAFELGVGRV IKGWDQGVAG MCVGEKRKLQ
110 120 130
IPSSLAYGER GVPGVIPPSA DLVFDVELVD VKSAA
Length:135
Mass (Da):14,487
Last modified:October 1, 1993 - v1
Checksum:i09CA3F1568D7E4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90646 Genomic DNA. Translation: AAA34604.1.
M90767 Genomic DNA. Translation: AAA34605.1.
U33057 Genomic DNA. Translation: AAB64960.1.
AY558177 Genomic DNA. Translation: AAS56503.1.
BK006938 Genomic DNA. Translation: DAA12350.1.
PIRiS25337.
RefSeqiNP_010807.3. NM_001180827.3.

Genome annotation databases

EnsemblFungiiYDR519W; YDR519W; YDR519W.
GeneIDi852131.
KEGGisce:YDR519W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90646 Genomic DNA. Translation: AAA34604.1.
M90767 Genomic DNA. Translation: AAA34605.1.
U33057 Genomic DNA. Translation: AAB64960.1.
AY558177 Genomic DNA. Translation: AAS56503.1.
BK006938 Genomic DNA. Translation: DAA12350.1.
PIRiS25337.
RefSeqiNP_010807.3. NM_001180827.3.

3D structure databases

ProteinModelPortaliP32472.
SMRiP32472. Positions 39-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32570. 22 interactions.
IntActiP32472. 45 interactions.
MINTiMINT-2779497.

Proteomic databases

MaxQBiP32472.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR519W; YDR519W; YDR519W.
GeneIDi852131.
KEGGisce:YDR519W.

Organism-specific databases

EuPathDBiFungiDB:YDR519W.
SGDiS000002927. FPR2.

Phylogenomic databases

GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
InParanoidiP32472.
KOiK09569.
OMAiRIPVEDC.
OrthoDBiEOG092C52SD.

Enzyme and pathway databases

BioCyciYEAST:YDR519W-MONOMER.

Miscellaneous databases

PROiP32472.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_YEAST
AccessioniPrimary (citable) accession number: P32472
Secondary accession number(s): D6VTE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5400 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.